Substantial effect of fenugreek seeds aqueous extract on serum estradiol level in ovarian hyperstimulation syndrome rat model

Objectives: Estradiol (E2) plays an important role in the pathophysiology of ovarian hyperstimulation syndrome (OHSS). This study aimed to evaluate the effect of fenugreek seed aqueous (FSA) extract on serum E2 levels in a rat model of OHSS. Methods: A total of 34 female Sprague Dawley rats, aged...

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Main Authors:	Ben Hameid, Asma, Al-Sindi, Taha, Allow, Ahmed Kaid Naji, Abdel Wahab, Emad Mohamad Nafie, Mustafa Al-Ahmad, Basma Ezzat, Faisal, Ghasak Ghazi
Format:	Article
Language:	English English
Published:	Oman Medical Speciality Board 2019
Subjects:	R Medicine (General) RB Pathology
Online Access:	http://irep.iium.edu.my/72106/ http://irep.iium.edu.my/72106/ http://irep.iium.edu.my/72106/1/Substantial%20Effect%20of%20Fenugreek%20Seeds%29.pdf http://irep.iium.edu.my/72106/7/72106_Substantial%20effect%20of%20fenugreek%20seeds%20aqueous%20extract_scopus.pdf

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recordtype	eprints
spelling	iium-721062019-11-17T16:19:38Z http://irep.iium.edu.my/72106/ Substantial effect of fenugreek seeds aqueous extract on serum estradiol level in ovarian hyperstimulation syndrome rat model Ben Hameid, Asma Al-Sindi, Taha Allow, Ahmed Kaid Naji Abdel Wahab, Emad Mohamad Nafie Mustafa Al-Ahmad, Basma Ezzat Faisal, Ghasak Ghazi R Medicine (General) RB Pathology Objectives: Estradiol (E2) plays an important role in the pathophysiology of ovarian hyperstimulation syndrome (OHSS). This study aimed to evaluate the effect of fenugreek seed aqueous (FSA) extract on serum E2 levels in a rat model of OHSS. Methods: A total of 34 female Sprague Dawley rats, aged 18 days old, weighing 40 to 45 g, were randomly divided into negative control, positive control, and treatment groups. A daily dose of 1500 mg/kg per body weight of FSA extract was administrated orally to rats in the treatment group for 13 days. On day eight of the study, OHSS was induced in both positive control and treated groups by subcutaneous injection of pregnant mare’s serum gonadotropin 50 IU for four consecutive days, followed by human chorionic gonadotropin 25 IU on the fifth day. The effect of FSA extract was evaluated by measuring the concentration of serum E2 using the enzyme-linked immunosorbent assay. Results: FSA extract reduced serum E2 level significantly in the treated OHSS model (p-value < 0.050) compared to the positive control group. Conclusions: The finding has important implications on the development of female infertility adjuvant drugs for safe assisted reproduction technology cycles in terms of OHSS prevention. Oman Medical Speciality Board 2019 Article PeerReviewed application/pdf en http://irep.iium.edu.my/72106/1/Substantial%20Effect%20of%20Fenugreek%20Seeds%29.pdf application/pdf en http://irep.iium.edu.my/72106/7/72106_Substantial%20effect%20of%20fenugreek%20seeds%20aqueous%20extract_scopus.pdf Ben Hameid, Asma and Al-Sindi, Taha and Allow, Ahmed Kaid Naji and Abdel Wahab, Emad Mohamad Nafie and Mustafa Al-Ahmad, Basma Ezzat and Faisal, Ghasak Ghazi (2019) Substantial effect of fenugreek seeds aqueous extract on serum estradiol level in ovarian hyperstimulation syndrome rat model. Oman Medical Journal, 34 (3). pp. 238-243. ISSN 1999-768X E-ISSN 2070-5204 http://www.omjournal.org/PDF/OS-OMJ-D-18-00057_(04C).pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	R Medicine (General) RB Pathology
spellingShingle	R Medicine (General) RB Pathology Ben Hameid, Asma Al-Sindi, Taha Allow, Ahmed Kaid Naji Abdel Wahab, Emad Mohamad Nafie Mustafa Al-Ahmad, Basma Ezzat Faisal, Ghasak Ghazi Substantial effect of fenugreek seeds aqueous extract on serum estradiol level in ovarian hyperstimulation syndrome rat model
description	Objectives: Estradiol (E2) plays an important role in the pathophysiology of ovarian hyperstimulation syndrome (OHSS). This study aimed to evaluate the effect of fenugreek seed aqueous (FSA) extract on serum E2 levels in a rat model of OHSS. Methods: A total of 34 female Sprague Dawley rats, aged 18 days old, weighing 40 to 45 g, were randomly divided into negative control, positive control, and treatment groups. A daily dose of 1500 mg/kg per body weight of FSA extract was administrated orally to rats in the treatment group for 13 days. On day eight of the study, OHSS was induced in both positive control and treated groups by subcutaneous injection of pregnant mare’s serum gonadotropin 50 IU for four consecutive days, followed by human chorionic gonadotropin 25 IU on the fifth day. The effect of FSA extract was evaluated by measuring the concentration of serum E2 using the enzyme-linked immunosorbent assay. Results: FSA extract reduced serum E2 level significantly in the treated OHSS model (p-value < 0.050) compared to the positive control group. Conclusions: The finding has important implications on the development of female infertility adjuvant drugs for safe assisted reproduction technology cycles in terms of OHSS prevention.
format	Article
author	Ben Hameid, Asma Al-Sindi, Taha Allow, Ahmed Kaid Naji Abdel Wahab, Emad Mohamad Nafie Mustafa Al-Ahmad, Basma Ezzat Faisal, Ghasak Ghazi
author_facet	Ben Hameid, Asma Al-Sindi, Taha Allow, Ahmed Kaid Naji Abdel Wahab, Emad Mohamad Nafie Mustafa Al-Ahmad, Basma Ezzat Faisal, Ghasak Ghazi
author_sort	Ben Hameid, Asma
title	Substantial effect of fenugreek seeds aqueous extract on serum estradiol level in ovarian hyperstimulation syndrome rat model
title_short	Substantial effect of fenugreek seeds aqueous extract on serum estradiol level in ovarian hyperstimulation syndrome rat model
title_full	Substantial effect of fenugreek seeds aqueous extract on serum estradiol level in ovarian hyperstimulation syndrome rat model
title_fullStr	Substantial effect of fenugreek seeds aqueous extract on serum estradiol level in ovarian hyperstimulation syndrome rat model
title_full_unstemmed	Substantial effect of fenugreek seeds aqueous extract on serum estradiol level in ovarian hyperstimulation syndrome rat model
title_sort	substantial effect of fenugreek seeds aqueous extract on serum estradiol level in ovarian hyperstimulation syndrome rat model
publisher	Oman Medical Speciality Board
publishDate	2019
url	http://irep.iium.edu.my/72106/ http://irep.iium.edu.my/72106/ http://irep.iium.edu.my/72106/1/Substantial%20Effect%20of%20Fenugreek%20Seeds%29.pdf http://irep.iium.edu.my/72106/7/72106_Substantial%20effect%20of%20fenugreek%20seeds%20aqueous%20extract_scopus.pdf
first_indexed	2023-09-18T21:42:13Z
last_indexed	2023-09-18T21:42:13Z
_version_	1777413216159137792

Substantial effect of fenugreek seeds aqueous extract on serum estradiol level in ovarian hyperstimulation syndrome rat model

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