Comparative analysis of subjective and objective clinical pterygium grading based on its redness appearance

Pterygium is wing-shaped, vascular and fleshy growth which encroaches from bulbar conjunctiva and progresses towards central cornea. Pterygium has been established as one of the factors which cause induced-corneal astigmatism, alteration of anterior corneal parameter, and changes in corneal topograp...

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Main Authors:	Hilmi, Mohd Radzi, Che Azemin, Mohd Zulfaezal, Mohd Kamal, Khairidzan
Format:	Conference or Workshop Item
Language:	English English
Published:	ICVS2015 Organizing Committee 2015
Subjects:	RE Ophthalmology
Online Access:	http://irep.iium.edu.my/72286/ http://irep.iium.edu.my/72286/ http://irep.iium.edu.my/72286/7/IMG-1770.JPG http://irep.iium.edu.my/72286/8/72286_Comparative%20analysis%20of%20subjective.pdf

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spelling	iium-722862019-07-03T03:45:06Z http://irep.iium.edu.my/72286/ Comparative analysis of subjective and objective clinical pterygium grading based on its redness appearance Hilmi, Mohd Radzi Che Azemin, Mohd Zulfaezal Mohd Kamal, Khairidzan RE Ophthalmology Pterygium is wing-shaped, vascular and fleshy growth which encroaches from bulbar conjunctiva and progresses towards central cornea. Pterygium has been established as one of the factors which cause induced-corneal astigmatism, alteration of anterior corneal parameter, and changes in corneal topography. However, lack of research address the clinical agreement of subjective clinical grading based on its redness appearance, severity and properties of the tissue. Thus, this research aimed to assess both subjective and objective clinical agreement based on its redness appearance and mimic it with human color perception. In this research work, 68 pterygium fibrovascular images were captured in a standardized magnification and illumination. All images were stored in JPEG format and randomize sorted. The images were compared and graded based on reference images described in previous study by two observers. The time interval between intra and inter-session were set at least a month apart. Similar sets of images were used to mimic human color perception. Mimicking human color perception has commonly employed RGB color space, which is inadequate. When the CIELab features were extracted in various color space, it showed better representation of human perception (correlation coefficient = 0.68) compared to using vesselness filter (correlation coefficient = 0.43). This research work also found that for the subjective clinical grading, both intra-observer intraclass correlation (0.957, 95% CI: 0.930 – 0.973) (P = 0.001) and inter-observer (0.937, 95% CI: 0.898 – 0.961) (P = 0.001) shows excellent agreement respectively. In conclusion, this research work found that intra and inter- observer correlation were excellent, which proved that the individual variability is minimal in normal color perception. In addition, this research work also found that the CIELab can serve as a basis for future work on to automate pterygium clinical grading based on tissue redness which may reduce clinician bias and set a new standard for clinical pterygium assessment. ICVS2015 Organizing Committee 2015-07-04 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/72286/7/IMG-1770.JPG application/pdf en http://irep.iium.edu.my/72286/8/72286_Comparative%20analysis%20of%20subjective.pdf Hilmi, Mohd Radzi and Che Azemin, Mohd Zulfaezal and Mohd Kamal, Khairidzan (2015) Comparative analysis of subjective and objective clinical pterygium grading based on its redness appearance. In: The 23rd Symposium of the International Colour Vision Society (ICVS) 2015, 4th July 2015, Sendai, Japan. http://www.vision.riec.tohoku.ac.jp/ICVS2015/committee.html
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RE Ophthalmology
spellingShingle	RE Ophthalmology Hilmi, Mohd Radzi Che Azemin, Mohd Zulfaezal Mohd Kamal, Khairidzan Comparative analysis of subjective and objective clinical pterygium grading based on its redness appearance
description	Pterygium is wing-shaped, vascular and fleshy growth which encroaches from bulbar conjunctiva and progresses towards central cornea. Pterygium has been established as one of the factors which cause induced-corneal astigmatism, alteration of anterior corneal parameter, and changes in corneal topography. However, lack of research address the clinical agreement of subjective clinical grading based on its redness appearance, severity and properties of the tissue. Thus, this research aimed to assess both subjective and objective clinical agreement based on its redness appearance and mimic it with human color perception. In this research work, 68 pterygium fibrovascular images were captured in a standardized magnification and illumination. All images were stored in JPEG format and randomize sorted. The images were compared and graded based on reference images described in previous study by two observers. The time interval between intra and inter-session were set at least a month apart. Similar sets of images were used to mimic human color perception. Mimicking human color perception has commonly employed RGB color space, which is inadequate. When the CIELab features were extracted in various color space, it showed better representation of human perception (correlation coefficient = 0.68) compared to using vesselness filter (correlation coefficient = 0.43). This research work also found that for the subjective clinical grading, both intra-observer intraclass correlation (0.957, 95% CI: 0.930 – 0.973) (P = 0.001) and inter-observer (0.937, 95% CI: 0.898 – 0.961) (P = 0.001) shows excellent agreement respectively. In conclusion, this research work found that intra and inter- observer correlation were excellent, which proved that the individual variability is minimal in normal color perception. In addition, this research work also found that the CIELab can serve as a basis for future work on to automate pterygium clinical grading based on tissue redness which may reduce clinician bias and set a new standard for clinical pterygium assessment.
format	Conference or Workshop Item
author	Hilmi, Mohd Radzi Che Azemin, Mohd Zulfaezal Mohd Kamal, Khairidzan
author_facet	Hilmi, Mohd Radzi Che Azemin, Mohd Zulfaezal Mohd Kamal, Khairidzan
author_sort	Hilmi, Mohd Radzi
title	Comparative analysis of subjective and objective clinical pterygium grading based on its redness appearance
title_short	Comparative analysis of subjective and objective clinical pterygium grading based on its redness appearance
title_full	Comparative analysis of subjective and objective clinical pterygium grading based on its redness appearance
title_fullStr	Comparative analysis of subjective and objective clinical pterygium grading based on its redness appearance
title_full_unstemmed	Comparative analysis of subjective and objective clinical pterygium grading based on its redness appearance
title_sort	comparative analysis of subjective and objective clinical pterygium grading based on its redness appearance
publisher	ICVS2015 Organizing Committee
publishDate	2015
url	http://irep.iium.edu.my/72286/ http://irep.iium.edu.my/72286/ http://irep.iium.edu.my/72286/7/IMG-1770.JPG http://irep.iium.edu.my/72286/8/72286_Comparative%20analysis%20of%20subjective.pdf
first_indexed	2023-09-18T21:42:25Z
last_indexed	2023-09-18T21:42:25Z
_version_	1777413227961909248

Comparative analysis of subjective and objective clinical pterygium grading based on its redness appearance

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