Effects of Eurycoma longifolia Jack on chronic hypoperfusion-induced oxidative damage and memory deficit in rats

Decreased cerebral blood supply, which is associated with dementia, results in chronic cerebral hypoperfusion (CCH), a physiopathological mechanism of neural dysfunction in Alzheimer’s disease. Eurycoma longifolia (EL) Jack has been documented to have multiple biological activities. The current st...

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Main Authors:	Saleh Alruhaimi, Hulol, Allow, Ahmed Kaid Naji, Buyong, Zunariah, Bahbah, Mohammad Nasser Hamed Mahmoud, Rahman, Shaikh Mizanur
Format:	Article
Language:	English English
Published:	Open Science Publishers LLP, 2019
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/72512/ http://irep.iium.edu.my/72512/ http://irep.iium.edu.my/72512/ http://irep.iium.edu.my/72512/7/72512%20Effects%20of%20Eurycoma%20longifolia%20Jack.pdf http://irep.iium.edu.my/72512/8/72512%20Effects%20of%20Eurycoma%20longifolia%20Jack%20SCOPUS.pdf

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spelling	iium-725122019-11-20T09:15:13Z http://irep.iium.edu.my/72512/ Effects of Eurycoma longifolia Jack on chronic hypoperfusion-induced oxidative damage and memory deficit in rats Saleh Alruhaimi, Hulol Allow, Ahmed Kaid Naji Buyong, Zunariah Bahbah, Mohammad Nasser Hamed Mahmoud Rahman, Shaikh Mizanur R Medicine (General) Decreased cerebral blood supply, which is associated with dementia, results in chronic cerebral hypoperfusion (CCH), a physiopathological mechanism of neural dysfunction in Alzheimer’s disease. Eurycoma longifolia (EL) Jack has been documented to have multiple biological activities. The current study aimed to determine the potential effect of EL root extracts in CCH using a 2-vessel occlusion (2VO) model. CCH was induced by a permanent bilateral ligation of the common carotid arteries in male Sprague–Dawley rats. The experimental groups were divided as follows: a sham-operated group, a 2VO group without any treatment, and a 2VO group that was orally administered EL extract (100 mg/kg/day) for 3 days before the day of 2VO surgery and continued until the end of postoperative week 8. Spatial memory performance was assessed by the Morris water maze test. Moreover, malondialdehyde (MDA) concentration and superoxide dismutase activity, glutathione level, and C-reactive protein (CRP) concentration in serum were measured. CCH rats showed significant cognitive impairment, decreased antioxidant activities, and increased MDA and CRP concentration in serum. The group that was orally administered EL extract showed a slight preservation of cognitive function, enhanced antioxidant activity, decreased MDA and CRP concentration than did the untreated 2VO group. EL offers potential neuroprotective effects due to its antioxidant and anti-inflammatory properties. Open Science Publishers LLP, 2019-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/72512/7/72512%20Effects%20of%20Eurycoma%20longifolia%20Jack.pdf application/pdf en http://irep.iium.edu.my/72512/8/72512%20Effects%20of%20Eurycoma%20longifolia%20Jack%20SCOPUS.pdf Saleh Alruhaimi, Hulol and Allow, Ahmed Kaid Naji and Buyong, Zunariah and Bahbah, Mohammad Nasser Hamed Mahmoud and Rahman, Shaikh Mizanur (2019) Effects of Eurycoma longifolia Jack on chronic hypoperfusion-induced oxidative damage and memory deficit in rats. Journal of Applied Pharmaceutical Science, 9 (4). pp. 77-81. ISSN 2231-3354 https://www.japsonline.com/admin/php/uploads/2893_pdf.pdf 10.7324/JAPS.2019.90409
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Saleh Alruhaimi, Hulol Allow, Ahmed Kaid Naji Buyong, Zunariah Bahbah, Mohammad Nasser Hamed Mahmoud Rahman, Shaikh Mizanur Effects of Eurycoma longifolia Jack on chronic hypoperfusion-induced oxidative damage and memory deficit in rats
description	Decreased cerebral blood supply, which is associated with dementia, results in chronic cerebral hypoperfusion (CCH), a physiopathological mechanism of neural dysfunction in Alzheimer’s disease. Eurycoma longifolia (EL) Jack has been documented to have multiple biological activities. The current study aimed to determine the potential effect of EL root extracts in CCH using a 2-vessel occlusion (2VO) model. CCH was induced by a permanent bilateral ligation of the common carotid arteries in male Sprague–Dawley rats. The experimental groups were divided as follows: a sham-operated group, a 2VO group without any treatment, and a 2VO group that was orally administered EL extract (100 mg/kg/day) for 3 days before the day of 2VO surgery and continued until the end of postoperative week 8. Spatial memory performance was assessed by the Morris water maze test. Moreover, malondialdehyde (MDA) concentration and superoxide dismutase activity, glutathione level, and C-reactive protein (CRP) concentration in serum were measured. CCH rats showed significant cognitive impairment, decreased antioxidant activities, and increased MDA and CRP concentration in serum. The group that was orally administered EL extract showed a slight preservation of cognitive function, enhanced antioxidant activity, decreased MDA and CRP concentration than did the untreated 2VO group. EL offers potential neuroprotective effects due to its antioxidant and anti-inflammatory properties.
format	Article
author	Saleh Alruhaimi, Hulol Allow, Ahmed Kaid Naji Buyong, Zunariah Bahbah, Mohammad Nasser Hamed Mahmoud Rahman, Shaikh Mizanur
author_facet	Saleh Alruhaimi, Hulol Allow, Ahmed Kaid Naji Buyong, Zunariah Bahbah, Mohammad Nasser Hamed Mahmoud Rahman, Shaikh Mizanur
author_sort	Saleh Alruhaimi, Hulol
title	Effects of Eurycoma longifolia Jack on chronic hypoperfusion-induced oxidative damage and memory deficit in rats
title_short	Effects of Eurycoma longifolia Jack on chronic hypoperfusion-induced oxidative damage and memory deficit in rats
title_full	Effects of Eurycoma longifolia Jack on chronic hypoperfusion-induced oxidative damage and memory deficit in rats
title_fullStr	Effects of Eurycoma longifolia Jack on chronic hypoperfusion-induced oxidative damage and memory deficit in rats
title_full_unstemmed	Effects of Eurycoma longifolia Jack on chronic hypoperfusion-induced oxidative damage and memory deficit in rats
title_sort	effects of eurycoma longifolia jack on chronic hypoperfusion-induced oxidative damage and memory deficit in rats
publisher	Open Science Publishers LLP,
publishDate	2019
url	http://irep.iium.edu.my/72512/ http://irep.iium.edu.my/72512/ http://irep.iium.edu.my/72512/ http://irep.iium.edu.my/72512/7/72512%20Effects%20of%20Eurycoma%20longifolia%20Jack.pdf http://irep.iium.edu.my/72512/8/72512%20Effects%20of%20Eurycoma%20longifolia%20Jack%20SCOPUS.pdf
first_indexed	2023-09-18T21:42:43Z
last_indexed	2023-09-18T21:42:43Z
_version_	1777413247419285504

Effects of Eurycoma longifolia Jack on chronic hypoperfusion-induced oxidative damage and memory deficit in rats

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