Morphological evaluation of aortic vessel in Spontaneously Hypertensive Rat (SHR) Models

The spontaneously hypertensive rat (SHR) has been well established as a suitable model for hypertension research, but little is known about the morphology of hypertensive vascular remodeling in this model. The present study was designed to investigate the structural changes of blood vessels in 6 m...

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Main Authors:	Ramli, Nurul Syahida, Baharun, Bibi Nur Bazlini, Ismail, Azlini, Abu Bakar, Nor Hidayah, Noordin, Liza, Wan Ahmad, Wan Amir Nizam
Format:	Article
Language:	English
Published:	Microscopy Society (Singapore) 2019
Subjects:	RB Pathology
Online Access:	http://irep.iium.edu.my/72699/ http://irep.iium.edu.my/72699/ http://irep.iium.edu.my/72699/1/72699_Morphological%20Evaluation%20of%20Aortic.pdf

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spelling	iium-726992019-06-19T02:35:48Z http://irep.iium.edu.my/72699/ Morphological evaluation of aortic vessel in Spontaneously Hypertensive Rat (SHR) Models Ramli, Nurul Syahida Baharun, Bibi Nur Bazlini Ismail, Azlini Abu Bakar, Nor Hidayah Noordin, Liza Wan Ahmad, Wan Amir Nizam RB Pathology The spontaneously hypertensive rat (SHR) has been well established as a suitable model for hypertension research, but little is known about the morphology of hypertensive vascular remodeling in this model. The present study was designed to investigate the structural changes of blood vessels in 6 months aged SHR in comparison to their corresponding model, Wistar Kyoto rats (WKY). The study utilised 12 male rats; which were equally divided into 6 SHR and 6 WKY. During dissection, thoracic aorta was harvested for histological examination. To evaluate the morphological appearance of SHR and WKY, hematoxylin and eosin (H&E) stain was done. Whereas Scanning electron microscopy was applied to view the ultrastructure of the vessel. The result shows that the aorta histology of WKY looks normal; depicted by showing smooth intima with a single layer of endothelial cells. In contrast with SHR, the structure was slightly distorted and thicker intima observed; suggesting vascular remodeling has occurred. Microscopy Society (Singapore) 2019-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/72699/1/72699_Morphological%20Evaluation%20of%20Aortic.pdf Ramli, Nurul Syahida and Baharun, Bibi Nur Bazlini and Ismail, Azlini and Abu Bakar, Nor Hidayah and Noordin, Liza and Wan Ahmad, Wan Amir Nizam (2019) Morphological evaluation of aortic vessel in Spontaneously Hypertensive Rat (SHR) Models. Annals of Microscopy, 18. pp. 4-10. ISSN 0219-2209 http://www.microscopy.org.sg/annals%20of%20microscopy.html
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RB Pathology
spellingShingle	RB Pathology Ramli, Nurul Syahida Baharun, Bibi Nur Bazlini Ismail, Azlini Abu Bakar, Nor Hidayah Noordin, Liza Wan Ahmad, Wan Amir Nizam Morphological evaluation of aortic vessel in Spontaneously Hypertensive Rat (SHR) Models
description	The spontaneously hypertensive rat (SHR) has been well established as a suitable model for hypertension research, but little is known about the morphology of hypertensive vascular remodeling in this model. The present study was designed to investigate the structural changes of blood vessels in 6 months aged SHR in comparison to their corresponding model, Wistar Kyoto rats (WKY). The study utilised 12 male rats; which were equally divided into 6 SHR and 6 WKY. During dissection, thoracic aorta was harvested for histological examination. To evaluate the morphological appearance of SHR and WKY, hematoxylin and eosin (H&E) stain was done. Whereas Scanning electron microscopy was applied to view the ultrastructure of the vessel. The result shows that the aorta histology of WKY looks normal; depicted by showing smooth intima with a single layer of endothelial cells. In contrast with SHR, the structure was slightly distorted and thicker intima observed; suggesting vascular remodeling has occurred.
format	Article
author	Ramli, Nurul Syahida Baharun, Bibi Nur Bazlini Ismail, Azlini Abu Bakar, Nor Hidayah Noordin, Liza Wan Ahmad, Wan Amir Nizam
author_facet	Ramli, Nurul Syahida Baharun, Bibi Nur Bazlini Ismail, Azlini Abu Bakar, Nor Hidayah Noordin, Liza Wan Ahmad, Wan Amir Nizam
author_sort	Ramli, Nurul Syahida
title	Morphological evaluation of aortic vessel in Spontaneously Hypertensive Rat (SHR) Models
title_short	Morphological evaluation of aortic vessel in Spontaneously Hypertensive Rat (SHR) Models
title_full	Morphological evaluation of aortic vessel in Spontaneously Hypertensive Rat (SHR) Models
title_fullStr	Morphological evaluation of aortic vessel in Spontaneously Hypertensive Rat (SHR) Models
title_full_unstemmed	Morphological evaluation of aortic vessel in Spontaneously Hypertensive Rat (SHR) Models
title_sort	morphological evaluation of aortic vessel in spontaneously hypertensive rat (shr) models
publisher	Microscopy Society (Singapore)
publishDate	2019
url	http://irep.iium.edu.my/72699/ http://irep.iium.edu.my/72699/ http://irep.iium.edu.my/72699/1/72699_Morphological%20Evaluation%20of%20Aortic.pdf
first_indexed	2023-09-18T21:43:02Z
last_indexed	2023-09-18T21:43:02Z
_version_	1777413266798018560

Morphological evaluation of aortic vessel in Spontaneously Hypertensive Rat (SHR) Models

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