Release study on electrospun PVA/chitosan-based nanofibers loaded with Centella Asiatica extracts

Background: Centella asiatica (CA) extracts is proven to be beneficial for wound healing treatment as the active constituent which are asiaticoside, madecassoside and asiatic acid possesses several medicinal effects such as antioxidant and anti-inflammatory. However, too much CA can cause severe sid...

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Main Authors:	Mohammad Rejab, Nur Farahanum, Wan Abdul Khodir, Wan Khartini, Bakhtiar, Muhammad Taher
Format:	Conference or Workshop Item
Language:	English English
Published:	2019
Subjects:	RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology
Online Access:	http://irep.iium.edu.my/73329/ http://irep.iium.edu.my/73329/10/73329%20Release%20study%20on%20electrospun.pdf http://irep.iium.edu.my/73329/11/73329%20slides.pdf

id	iium-73329
recordtype	eprints
spelling	iium-733292019-07-19T03:02:59Z http://irep.iium.edu.my/73329/ Release study on electrospun PVA/chitosan-based nanofibers loaded with Centella Asiatica extracts Mohammad Rejab, Nur Farahanum Wan Abdul Khodir, Wan Khartini Bakhtiar, Muhammad Taher RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology Background: Centella asiatica (CA) extracts is proven to be beneficial for wound healing treatment as the active constituent which are asiaticoside, madecassoside and asiatic acid possesses several medicinal effects such as antioxidant and anti-inflammatory. However, too much CA can cause severe side effect. Objective: In order to overcome the limitation, the efficacy of CA extract can be increased by using a suitable drug carrier such as polyvinyl alcohol (PVA) and chitosan (CS). Methodology: Methanolic extraction of CA was done by using maceration method by solvent methanol/water with ratio (9:1). PVA/chitosan loaded 2,4 and 6% of centella asiatica extract were successfully fabricated using electrospinning technique. Results: From SEM images showed PVA/chitosan loaded centella asiatica were homogenous and non-woven structure Conclusion: In vitro release study of Centella asiatica extract were measured by using HPLC and showed sustained release and obeyed the first order release kinetics. 2019 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/73329/10/73329%20Release%20study%20on%20electrospun.pdf application/pdf en http://irep.iium.edu.my/73329/11/73329%20slides.pdf Mohammad Rejab, Nur Farahanum and Wan Abdul Khodir, Wan Khartini and Bakhtiar, Muhammad Taher (2019) Release study on electrospun PVA/chitosan-based nanofibers loaded with Centella Asiatica extracts. In: 33rd Scientific Meeting Malaysian Society Of Pharmacology & Physiology (MSPP) 2019, 15th-16th July 2019, Putrajaya. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology
spellingShingle	RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology Mohammad Rejab, Nur Farahanum Wan Abdul Khodir, Wan Khartini Bakhtiar, Muhammad Taher Release study on electrospun PVA/chitosan-based nanofibers loaded with Centella Asiatica extracts
description	Background: Centella asiatica (CA) extracts is proven to be beneficial for wound healing treatment as the active constituent which are asiaticoside, madecassoside and asiatic acid possesses several medicinal effects such as antioxidant and anti-inflammatory. However, too much CA can cause severe side effect. Objective: In order to overcome the limitation, the efficacy of CA extract can be increased by using a suitable drug carrier such as polyvinyl alcohol (PVA) and chitosan (CS). Methodology: Methanolic extraction of CA was done by using maceration method by solvent methanol/water with ratio (9:1). PVA/chitosan loaded 2,4 and 6% of centella asiatica extract were successfully fabricated using electrospinning technique. Results: From SEM images showed PVA/chitosan loaded centella asiatica were homogenous and non-woven structure Conclusion: In vitro release study of Centella asiatica extract were measured by using HPLC and showed sustained release and obeyed the first order release kinetics.
format	Conference or Workshop Item
author	Mohammad Rejab, Nur Farahanum Wan Abdul Khodir, Wan Khartini Bakhtiar, Muhammad Taher
author_facet	Mohammad Rejab, Nur Farahanum Wan Abdul Khodir, Wan Khartini Bakhtiar, Muhammad Taher
author_sort	Mohammad Rejab, Nur Farahanum
title	Release study on electrospun PVA/chitosan-based nanofibers loaded with Centella Asiatica extracts
title_short	Release study on electrospun PVA/chitosan-based nanofibers loaded with Centella Asiatica extracts
title_full	Release study on electrospun PVA/chitosan-based nanofibers loaded with Centella Asiatica extracts
title_fullStr	Release study on electrospun PVA/chitosan-based nanofibers loaded with Centella Asiatica extracts
title_full_unstemmed	Release study on electrospun PVA/chitosan-based nanofibers loaded with Centella Asiatica extracts
title_sort	release study on electrospun pva/chitosan-based nanofibers loaded with centella asiatica extracts
publishDate	2019
url	http://irep.iium.edu.my/73329/ http://irep.iium.edu.my/73329/10/73329%20Release%20study%20on%20electrospun.pdf http://irep.iium.edu.my/73329/11/73329%20slides.pdf
first_indexed	2023-09-18T21:43:57Z
last_indexed	2023-09-18T21:43:57Z
_version_	1777413324594479104

Release study on electrospun PVA/chitosan-based nanofibers loaded with Centella Asiatica extracts

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