Optimization of aceclofenac proniosomes by using different carriers, part 1: development and characterization

In the contemporary medical model world, the proniosomal system has been serving as a new drug delivery system that is considered to significantly enhance the bioavailability of drugs with low water solubility. The application of this system can improve the bioavailability of aceclofenac that is us...

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Main Authors:	MF Sammour, Rana, Bakhtiar, Muhammad Taher, Chatterjee, Bappaditya, Shahiwala, Aliasgar, Mahmood, Syed
Format:	Article
Language:	English English
Published:	MDPI Basel 2019
Subjects:	RS192 Materia Medica-Pharmaceutical Technology
Online Access:	http://irep.iium.edu.my/73453/ http://irep.iium.edu.my/73453/ http://irep.iium.edu.my/73453/ http://irep.iium.edu.my/73453/1/pharmaceutics-11-00350%20%281%29.pdf http://irep.iium.edu.my/73453/7/73453_Optimization%20of%20aceclofenac%20proniosomes%20by%20using%20different%20carriers%2C%20part%201-%20Development%20and%20characterization_Scopus.pdf

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spelling	iium-734532019-11-24T13:39:09Z http://irep.iium.edu.my/73453/ Optimization of aceclofenac proniosomes by using different carriers, part 1: development and characterization MF Sammour, Rana Bakhtiar, Muhammad Taher Chatterjee, Bappaditya Shahiwala, Aliasgar Mahmood, Syed RS192 Materia Medica-Pharmaceutical Technology In the contemporary medical model world, the proniosomal system has been serving as a new drug delivery system that is considered to significantly enhance the bioavailability of drugs with low water solubility. The application of this system can improve the bioavailability of aceclofenac that is used for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. The present study is intended to develop an optimized proniosomal aceclofenac formula by the use of different carriers. Aceclofenac proniosomes have been prepared by slurry method, and different carriers such as maltodextrin, mannitol, and glucose were tried. Prepared proniosomes characterized by differential scanning calorimetry (DSC) analysis and Fourier transform infrared (FTIR) analysis revealed the compatibility of the drug chosen with the ingredient added, powder X-ray diffractometry (XRD) confirmed the amorphous phase of the prepared proniosomes, and finally, the surfactant layer was observed by scanning electron microscopy (SEM). Aceclofenac physical state transformations were confirmed with all formulas but maltodextrin proniosomes exhibited solubility more than other formulations. HPLC method has been used to analyze the niosomes derived from proniosomes in terms of their entrapment capability and drug content. The obtained results revealed that aceclofenac proniosomes can be successfully prepared by using different carriers. MDPI Basel 2019-07 Article PeerReviewed application/pdf en http://irep.iium.edu.my/73453/1/pharmaceutics-11-00350%20%281%29.pdf application/pdf en http://irep.iium.edu.my/73453/7/73453_Optimization%20of%20aceclofenac%20proniosomes%20by%20using%20different%20carriers%2C%20part%201-%20Development%20and%20characterization_Scopus.pdf MF Sammour, Rana and Bakhtiar, Muhammad Taher and Chatterjee, Bappaditya and Shahiwala, Aliasgar and Mahmood, Syed (2019) Optimization of aceclofenac proniosomes by using different carriers, part 1: development and characterization. Pharmaceutics, 11 (7). pp. 1-19. E-ISSN 1999-4923 https://www.mdpi.com/1999-4923/11/7/350 10.3390/pharmaceutics11070350
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS192 Materia Medica-Pharmaceutical Technology
spellingShingle	RS192 Materia Medica-Pharmaceutical Technology MF Sammour, Rana Bakhtiar, Muhammad Taher Chatterjee, Bappaditya Shahiwala, Aliasgar Mahmood, Syed Optimization of aceclofenac proniosomes by using different carriers, part 1: development and characterization
description	In the contemporary medical model world, the proniosomal system has been serving as a new drug delivery system that is considered to significantly enhance the bioavailability of drugs with low water solubility. The application of this system can improve the bioavailability of aceclofenac that is used for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. The present study is intended to develop an optimized proniosomal aceclofenac formula by the use of different carriers. Aceclofenac proniosomes have been prepared by slurry method, and different carriers such as maltodextrin, mannitol, and glucose were tried. Prepared proniosomes characterized by differential scanning calorimetry (DSC) analysis and Fourier transform infrared (FTIR) analysis revealed the compatibility of the drug chosen with the ingredient added, powder X-ray diffractometry (XRD) confirmed the amorphous phase of the prepared proniosomes, and finally, the surfactant layer was observed by scanning electron microscopy (SEM). Aceclofenac physical state transformations were confirmed with all formulas but maltodextrin proniosomes exhibited solubility more than other formulations. HPLC method has been used to analyze the niosomes derived from proniosomes in terms of their entrapment capability and drug content. The obtained results revealed that aceclofenac proniosomes can be successfully prepared by using different carriers.
format	Article
author	MF Sammour, Rana Bakhtiar, Muhammad Taher Chatterjee, Bappaditya Shahiwala, Aliasgar Mahmood, Syed
author_facet	MF Sammour, Rana Bakhtiar, Muhammad Taher Chatterjee, Bappaditya Shahiwala, Aliasgar Mahmood, Syed
author_sort	MF Sammour, Rana
title	Optimization of aceclofenac proniosomes by using different carriers, part 1: development and characterization
title_short	Optimization of aceclofenac proniosomes by using different carriers, part 1: development and characterization
title_full	Optimization of aceclofenac proniosomes by using different carriers, part 1: development and characterization
title_fullStr	Optimization of aceclofenac proniosomes by using different carriers, part 1: development and characterization
title_full_unstemmed	Optimization of aceclofenac proniosomes by using different carriers, part 1: development and characterization
title_sort	optimization of aceclofenac proniosomes by using different carriers, part 1: development and characterization
publisher	MDPI Basel
publishDate	2019
url	http://irep.iium.edu.my/73453/ http://irep.iium.edu.my/73453/ http://irep.iium.edu.my/73453/ http://irep.iium.edu.my/73453/1/pharmaceutics-11-00350%20%281%29.pdf http://irep.iium.edu.my/73453/7/73453_Optimization%20of%20aceclofenac%20proniosomes%20by%20using%20different%20carriers%2C%20part%201-%20Development%20and%20characterization_Scopus.pdf
first_indexed	2023-09-18T21:44:08Z
last_indexed	2023-09-18T21:44:08Z
_version_	1777413336747474944

Optimization of aceclofenac proniosomes by using different carriers, part 1: development and characterization

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