Fundamental study of acute myocardial infarction in young adults: identifying coronary artery disease-specific proteome panel as predictor of early significant coronary atherosclerosis in young adults.

Acute myocardial infarction (AMI) is the most common clinical manifestation of coronary artery disease (CAD). Hypertension was identified as an important risk factor of AMI at a young age. The identification of CAD biomarkers in these young adults is necessary as a tool for early prediction of CAD....

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Main Authors:	Abdullah, Aszrin, Mohd Shah, Azarisman Shah, Mohamed Bakrim, Norbaiyah
Format:	Monograph
Language:	English
Published:	2019
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/73591/ http://irep.iium.edu.my/73591/1/FULL%20REPORT%20FRGS%202019.pdf

id	iium-73591
recordtype	eprints
spelling	iium-735912019-10-22T09:23:47Z http://irep.iium.edu.my/73591/ Fundamental study of acute myocardial infarction in young adults: identifying coronary artery disease-specific proteome panel as predictor of early significant coronary atherosclerosis in young adults. Abdullah, Aszrin Mohd Shah, Azarisman Shah Mohamed Bakrim, Norbaiyah R Medicine (General) Acute myocardial infarction (AMI) is the most common clinical manifestation of coronary artery disease (CAD). Hypertension was identified as an important risk factor of AMI at a young age. The identification of CAD biomarkers in these young adults is necessary as a tool for early prediction of CAD. The objective of this study was to investigate protein expression profiles of young adults with AMI. A comparative cross-sectional study was conducted in 160 young adult males aged 18-45 years old (normotensives, prehypertensive, hypertensive and AMI groups). Sample analysis comprised of discovery and verification phases. In the discovery phase, proteins in the pooled plasma samples from 10 AMI patients and 10 controls, were separated by two-dimensional electrophoresis. The protein spots that were expressed differently in AMI patients were identified via MALDI-TOF mass spectrometry. In the verification phase, the plasma concentration of the identified proteins was measured using enzyme-linked immunosorbent assay (ELISA) in all 4 groups. Haptoglobin (Hp) was significantly higher in AMI patients in comparison to all 3 groups. Plasma Hp concentrations were significantly increased in young AMI patients relative to controls, prehypertensive and hypertensive subjects. Hp has a significant role as an inflammatory marker of CAD development in young adults. 2019-06-01 Monograph NonPeerReviewed application/pdf en http://irep.iium.edu.my/73591/1/FULL%20REPORT%20FRGS%202019.pdf Abdullah, Aszrin and Mohd Shah, Azarisman Shah and Mohamed Bakrim, Norbaiyah (2019) Fundamental study of acute myocardial infarction in young adults: identifying coronary artery disease-specific proteome panel as predictor of early significant coronary atherosclerosis in young adults. Research Report. UNSPECIFIED. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Abdullah, Aszrin Mohd Shah, Azarisman Shah Mohamed Bakrim, Norbaiyah Fundamental study of acute myocardial infarction in young adults: identifying coronary artery disease-specific proteome panel as predictor of early significant coronary atherosclerosis in young adults.
description	Acute myocardial infarction (AMI) is the most common clinical manifestation of coronary artery disease (CAD). Hypertension was identified as an important risk factor of AMI at a young age. The identification of CAD biomarkers in these young adults is necessary as a tool for early prediction of CAD. The objective of this study was to investigate protein expression profiles of young adults with AMI. A comparative cross-sectional study was conducted in 160 young adult males aged 18-45 years old (normotensives, prehypertensive, hypertensive and AMI groups). Sample analysis comprised of discovery and verification phases. In the discovery phase, proteins in the pooled plasma samples from 10 AMI patients and 10 controls, were separated by two-dimensional electrophoresis. The protein spots that were expressed differently in AMI patients were identified via MALDI-TOF mass spectrometry. In the verification phase, the plasma concentration of the identified proteins was measured using enzyme-linked immunosorbent assay (ELISA) in all 4 groups. Haptoglobin (Hp) was significantly higher in AMI patients in comparison to all 3 groups. Plasma Hp concentrations were significantly increased in young AMI patients relative to controls, prehypertensive and hypertensive subjects. Hp has a significant role as an inflammatory marker of CAD development in young adults.
format	Monograph
author	Abdullah, Aszrin Mohd Shah, Azarisman Shah Mohamed Bakrim, Norbaiyah
author_facet	Abdullah, Aszrin Mohd Shah, Azarisman Shah Mohamed Bakrim, Norbaiyah
author_sort	Abdullah, Aszrin
title	Fundamental study of acute myocardial infarction in young adults: identifying coronary artery disease-specific proteome panel as predictor of early significant coronary atherosclerosis in young adults.
title_short	Fundamental study of acute myocardial infarction in young adults: identifying coronary artery disease-specific proteome panel as predictor of early significant coronary atherosclerosis in young adults.
title_full	Fundamental study of acute myocardial infarction in young adults: identifying coronary artery disease-specific proteome panel as predictor of early significant coronary atherosclerosis in young adults.
title_fullStr	Fundamental study of acute myocardial infarction in young adults: identifying coronary artery disease-specific proteome panel as predictor of early significant coronary atherosclerosis in young adults.
title_full_unstemmed	Fundamental study of acute myocardial infarction in young adults: identifying coronary artery disease-specific proteome panel as predictor of early significant coronary atherosclerosis in young adults.
title_sort	fundamental study of acute myocardial infarction in young adults: identifying coronary artery disease-specific proteome panel as predictor of early significant coronary atherosclerosis in young adults.
publishDate	2019
url	http://irep.iium.edu.my/73591/ http://irep.iium.edu.my/73591/1/FULL%20REPORT%20FRGS%202019.pdf
first_indexed	2023-09-18T21:44:20Z
last_indexed	2023-09-18T21:44:20Z
_version_	1777413348684464128

Fundamental study of acute myocardial infarction in young adults: identifying coronary artery disease-specific proteome panel as predictor of early significant coronary atherosclerosis in young adults.

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