Development of biodegradable sustained-release damnacanthal nanocapsules for potential application in in-vitro breast cancer studies
The “noni” species of Morinda citrifolia L., is using in traditional medicine in the tropical country for over 2000 years. Noni fruit has come from the Morinda citrifolia tree which is called Rubiaceae, and it is from the coffee family. It is a perennial herb whose ripe fruit has a robust butyric a...
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| Format: | Article |
| Language: | English English |
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University of Karachi
2019
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| Online Access: | http://irep.iium.edu.my/73986/ http://irep.iium.edu.my/73986/ http://irep.iium.edu.my/73986/1/73986_Development%20of%20biodegradable%20sustained-release%20damnacanthal%20nanocapsules%20for%20potential%20application%20in%20in-vitro%20breast%20cancer%20studies.pdf http://irep.iium.edu.my/73986/2/73986_Development%20of%20biodegradable%20sustained-release%20damnacanthal%20nanocapsules%20for%20potential%20application%20in%20in-vitro%20breast%20cancer%20studies_SCOPUS.pdf |
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eprints |
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iium-739862019-11-19T06:21:15Z http://irep.iium.edu.my/73986/ Development of biodegradable sustained-release damnacanthal nanocapsules for potential application in in-vitro breast cancer studies Rahman, Mohd Mokhlesur Raja Hussin, Tengku Mohammad Ariff Mohamad, Nasir Abdul Latif, Ahmad Zubaidi Wan Nik, Wan Mohd Norsani Mohamed, Awang Mohamed Suffian, Izzat Fahimuddin QD Chemistry RM300 Drugs and their action RS403 Materia Medica-Pharmaceutical Chemistry The “noni” species of Morinda citrifolia L., is using in traditional medicine in the tropical country for over 2000 years. Noni fruit has come from the Morinda citrifolia tree which is called Rubiaceae, and it is from the coffee family. It is a perennial herb whose ripe fruit has a robust butyric acid smell and flavor. Recently scientists have proven that this fruit has antioxidant and antibiotic properties in vitro. An anthraquinone, damnacanthal, is one of the constituents of Morinda citrifolia. It has been demonstrated to have anti-cancer properties. Damnacanthal has low water solubility and low bioavailability. Formulating of damnacanthal into the biodegradable nanocapsule drug delivery system may increase its bioavailability. Various formulations of damnacanthal would be developed to enable the selection of a dosage form that could offer the provision of the anti-cancer bioactive substance with suitable sustained- or controlled release properties. The efficiency of extraction of damnacanthal will be compared using both conventional and traditional method. Both the damnacanthal and an anthraquinone active compounds extracted from noni roots, are currently being studied in the context of anti-cancer study. Soon, the medical values, bioactivities and nutritional of this fruit can be assessed, especially its anti-cancer activity, this fruit extract could play an outstanding economic role in Malaysia and other tropical countries. University of Karachi 2019-09 Article PeerReviewed application/pdf en http://irep.iium.edu.my/73986/1/73986_Development%20of%20biodegradable%20sustained-release%20damnacanthal%20nanocapsules%20for%20potential%20application%20in%20in-vitro%20breast%20cancer%20studies.pdf application/pdf en http://irep.iium.edu.my/73986/2/73986_Development%20of%20biodegradable%20sustained-release%20damnacanthal%20nanocapsules%20for%20potential%20application%20in%20in-vitro%20breast%20cancer%20studies_SCOPUS.pdf Rahman, Mohd Mokhlesur and Raja Hussin, Tengku Mohammad Ariff and Mohamad, Nasir and Abdul Latif, Ahmad Zubaidi and Wan Nik, Wan Mohd Norsani and Mohamed, Awang and Mohamed Suffian, Izzat Fahimuddin (2019) Development of biodegradable sustained-release damnacanthal nanocapsules for potential application in in-vitro breast cancer studies. Pakistan Journal of Pharmaceutical Sciences, 32 (5). pp. 2155-2162. ISSN 1011-601X http://www.pjps.pk/?page_id=276&id=5261 |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
| collection |
Online Access |
| language |
English English |
| topic |
QD Chemistry RM300 Drugs and their action RS403 Materia Medica-Pharmaceutical Chemistry |
| spellingShingle |
QD Chemistry RM300 Drugs and their action RS403 Materia Medica-Pharmaceutical Chemistry Rahman, Mohd Mokhlesur Raja Hussin, Tengku Mohammad Ariff Mohamad, Nasir Abdul Latif, Ahmad Zubaidi Wan Nik, Wan Mohd Norsani Mohamed, Awang Mohamed Suffian, Izzat Fahimuddin Development of biodegradable sustained-release damnacanthal nanocapsules for potential application in in-vitro breast cancer studies |
| description |
The “noni” species of Morinda citrifolia L., is using in traditional medicine in the tropical country for over
2000 years. Noni fruit has come from the Morinda citrifolia tree which is called Rubiaceae, and it is from the coffee family. It is a perennial herb whose ripe fruit has a robust butyric acid smell and flavor. Recently scientists have proven that this fruit has antioxidant and antibiotic properties in vitro. An anthraquinone, damnacanthal, is one of the constituents of Morinda citrifolia. It has been demonstrated to have anti-cancer properties. Damnacanthal has low water
solubility and low bioavailability. Formulating of damnacanthal into the biodegradable nanocapsule drug delivery system may increase its bioavailability. Various formulations of damnacanthal would be developed to enable the selection of a dosage form that could offer the provision of the anti-cancer bioactive substance with suitable sustained- or controlled release properties. The efficiency of extraction of damnacanthal will be compared using both conventional and traditional method. Both the damnacanthal and an anthraquinone active compounds extracted from noni roots, are currently being studied in the context of anti-cancer study. Soon, the medical values, bioactivities and nutritional of this fruit can be assessed, especially its anti-cancer activity, this fruit extract could play an outstanding economic role in
Malaysia and other tropical countries. |
| format |
Article |
| author |
Rahman, Mohd Mokhlesur Raja Hussin, Tengku Mohammad Ariff Mohamad, Nasir Abdul Latif, Ahmad Zubaidi Wan Nik, Wan Mohd Norsani Mohamed, Awang Mohamed Suffian, Izzat Fahimuddin |
| author_facet |
Rahman, Mohd Mokhlesur Raja Hussin, Tengku Mohammad Ariff Mohamad, Nasir Abdul Latif, Ahmad Zubaidi Wan Nik, Wan Mohd Norsani Mohamed, Awang Mohamed Suffian, Izzat Fahimuddin |
| author_sort |
Rahman, Mohd Mokhlesur |
| title |
Development of biodegradable sustained-release damnacanthal
nanocapsules for potential application in in-vitro breast cancer studies |
| title_short |
Development of biodegradable sustained-release damnacanthal
nanocapsules for potential application in in-vitro breast cancer studies |
| title_full |
Development of biodegradable sustained-release damnacanthal
nanocapsules for potential application in in-vitro breast cancer studies |
| title_fullStr |
Development of biodegradable sustained-release damnacanthal
nanocapsules for potential application in in-vitro breast cancer studies |
| title_full_unstemmed |
Development of biodegradable sustained-release damnacanthal
nanocapsules for potential application in in-vitro breast cancer studies |
| title_sort |
development of biodegradable sustained-release damnacanthal
nanocapsules for potential application in in-vitro breast cancer studies |
| publisher |
University of Karachi |
| publishDate |
2019 |
| url |
http://irep.iium.edu.my/73986/ http://irep.iium.edu.my/73986/ http://irep.iium.edu.my/73986/1/73986_Development%20of%20biodegradable%20sustained-release%20damnacanthal%20nanocapsules%20for%20potential%20application%20in%20in-vitro%20breast%20cancer%20studies.pdf http://irep.iium.edu.my/73986/2/73986_Development%20of%20biodegradable%20sustained-release%20damnacanthal%20nanocapsules%20for%20potential%20application%20in%20in-vitro%20breast%20cancer%20studies_SCOPUS.pdf |
| first_indexed |
2023-09-18T21:44:53Z |
| last_indexed |
2023-09-18T21:44:53Z |
| _version_ |
1777413383459438592 |