Anti-neoplastic potential of ethyl-p-methoxycinnamate of Kaempferia galanga on oral cancer cell lines

Kaempferia galanga is one of the herbal plant that have many medicinal properties. The plant extract has also been reported to possess in vitro anti-cancer activities on various cancer cell lines such as human colon cancer SW620, cervical cancer C33A, and breast cancer MCF-7 cell lines. Ethyl-p-meth...

Full description

Bibliographic Details
Main Authors:	Ichwan, Solachuddin J. A., Husin, Atiyah, Suriyah, Wastuti Hidayati, Lestari, Widya, Omar, Muhammad Nor, Kasmuri, Abdul Razak
Format:	Conference or Workshop Item
Language:	English English
Published:	Elsevier 2019
Subjects:	RK Dentistry RM Therapeutics. Pharmacology
Online Access:	http://irep.iium.edu.my/74084/ http://irep.iium.edu.my/74084/ http://irep.iium.edu.my/74084/ http://irep.iium.edu.my/74084/7/74084%20Anti-neoplastic%20potential%20of%20ethyl-p-methoxycinnamate%20of.pdf http://irep.iium.edu.my/74084/13/74084_Anti-neoplastic%20potential%20of%20ethyl-p-methoxycinnamate%20of%20Kaempferia%20galanga%20on%20oral%20cancer%20cell%20lines_Scopus.pdf

id	iium-74084
recordtype	eprints
spelling	iium-740842019-11-26T08:15:37Z http://irep.iium.edu.my/74084/ Anti-neoplastic potential of ethyl-p-methoxycinnamate of Kaempferia galanga on oral cancer cell lines Ichwan, Solachuddin J. A. Husin, Atiyah Suriyah, Wastuti Hidayati Lestari, Widya Omar, Muhammad Nor Kasmuri, Abdul Razak RK Dentistry RM Therapeutics. Pharmacology Kaempferia galanga is one of the herbal plant that have many medicinal properties. The plant extract has also been reported to possess in vitro anti-cancer activities on various cancer cell lines such as human colon cancer SW620, cervical cancer C33A, and breast cancer MCF-7 cell lines. Ethyl-p-methoxycinnamate (EPMC), a major constituent of volatile oil of Kaempferia galanga has been attributed to its medicinal benefits. We report here for the first time the anticancer potential of EPMC on oral cancer cells derived from human oral cavity, HSC-3 and Ca922 lines. MTT assay results showed that EPMC markedly induced cytotoxicity on HSC-3 (IC50 0.075 mg/mL) and Ca922 (IC50 0.085 mg/mL) cell lines. The apoptotic activity induced by EPMC was detected in both cell lines by flow cytometry and confirmed with Caspase 3/7 assay. Moreover, quantitative RT-PCR analysis revealed that EPMC-induced apoptosis in both lines elevated the mRNA levels of pro-apoptotic genes caspase-9 and PUMA. These results suggest that EPMC may be a potential candidate for oral cancer treatment. Elsevier 2019 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/74084/7/74084%20Anti-neoplastic%20potential%20of%20ethyl-p-methoxycinnamate%20of.pdf application/pdf en http://irep.iium.edu.my/74084/13/74084_Anti-neoplastic%20potential%20of%20ethyl-p-methoxycinnamate%20of%20Kaempferia%20galanga%20on%20oral%20cancer%20cell%20lines_Scopus.pdf Ichwan, Solachuddin J. A. and Husin, Atiyah and Suriyah, Wastuti Hidayati and Lestari, Widya and Omar, Muhammad Nor and Kasmuri, Abdul Razak (2019) Anti-neoplastic potential of ethyl-p-methoxycinnamate of Kaempferia galanga on oral cancer cell lines. In: Conference on BioMedical and Advanced Materials (Bio-CAM 2017), 28-29th November 2017, Pulau Langkawi, Kedah. https://www.sciencedirect.com/science/article/pii/S221478531931449X 10.1016/j.matpr.2019.06.100
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RK Dentistry RM Therapeutics. Pharmacology
spellingShingle	RK Dentistry RM Therapeutics. Pharmacology Ichwan, Solachuddin J. A. Husin, Atiyah Suriyah, Wastuti Hidayati Lestari, Widya Omar, Muhammad Nor Kasmuri, Abdul Razak Anti-neoplastic potential of ethyl-p-methoxycinnamate of Kaempferia galanga on oral cancer cell lines
description	Kaempferia galanga is one of the herbal plant that have many medicinal properties. The plant extract has also been reported to possess in vitro anti-cancer activities on various cancer cell lines such as human colon cancer SW620, cervical cancer C33A, and breast cancer MCF-7 cell lines. Ethyl-p-methoxycinnamate (EPMC), a major constituent of volatile oil of Kaempferia galanga has been attributed to its medicinal benefits. We report here for the first time the anticancer potential of EPMC on oral cancer cells derived from human oral cavity, HSC-3 and Ca922 lines. MTT assay results showed that EPMC markedly induced cytotoxicity on HSC-3 (IC50 0.075 mg/mL) and Ca922 (IC50 0.085 mg/mL) cell lines. The apoptotic activity induced by EPMC was detected in both cell lines by flow cytometry and confirmed with Caspase 3/7 assay. Moreover, quantitative RT-PCR analysis revealed that EPMC-induced apoptosis in both lines elevated the mRNA levels of pro-apoptotic genes caspase-9 and PUMA. These results suggest that EPMC may be a potential candidate for oral cancer treatment.
format	Conference or Workshop Item
author	Ichwan, Solachuddin J. A. Husin, Atiyah Suriyah, Wastuti Hidayati Lestari, Widya Omar, Muhammad Nor Kasmuri, Abdul Razak
author_facet	Ichwan, Solachuddin J. A. Husin, Atiyah Suriyah, Wastuti Hidayati Lestari, Widya Omar, Muhammad Nor Kasmuri, Abdul Razak
author_sort	Ichwan, Solachuddin J. A.
title	Anti-neoplastic potential of ethyl-p-methoxycinnamate of Kaempferia galanga on oral cancer cell lines
title_short	Anti-neoplastic potential of ethyl-p-methoxycinnamate of Kaempferia galanga on oral cancer cell lines
title_full	Anti-neoplastic potential of ethyl-p-methoxycinnamate of Kaempferia galanga on oral cancer cell lines
title_fullStr	Anti-neoplastic potential of ethyl-p-methoxycinnamate of Kaempferia galanga on oral cancer cell lines
title_full_unstemmed	Anti-neoplastic potential of ethyl-p-methoxycinnamate of Kaempferia galanga on oral cancer cell lines
title_sort	anti-neoplastic potential of ethyl-p-methoxycinnamate of kaempferia galanga on oral cancer cell lines
publisher	Elsevier
publishDate	2019
url	http://irep.iium.edu.my/74084/ http://irep.iium.edu.my/74084/ http://irep.iium.edu.my/74084/ http://irep.iium.edu.my/74084/7/74084%20Anti-neoplastic%20potential%20of%20ethyl-p-methoxycinnamate%20of.pdf http://irep.iium.edu.my/74084/13/74084_Anti-neoplastic%20potential%20of%20ethyl-p-methoxycinnamate%20of%20Kaempferia%20galanga%20on%20oral%20cancer%20cell%20lines_Scopus.pdf
first_indexed	2023-09-18T21:44:57Z
last_indexed	2023-09-18T21:44:57Z
_version_	1777413388243042304

Anti-neoplastic potential of ethyl-p-methoxycinnamate of Kaempferia galanga on oral cancer cell lines

Similar Items