Periodic assessment of antenatal and post natal serum endothelin-1 (ET-1) and nitric oxide (NO) levels in hypertensive disorders of pregnancy (HDP)

Periodic assessment of antenatal and post natal serum endothelin-1 (ET-1) and nitric oxide (NO) levels in hypertensive disorders of pregnancy (HDP)

Introduction: Hypertensive Disorders of Pregnancy (HDP) is an independent risk factor of cardiovascular (CVS) disease with endothelial dysfunction postulated to be the pathophysiology. Endothelin-1 (ET-1), a potent vasoconstrictor, has been identified as a pivotal mediator in HDP. Disturbances in ni...

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Main Authors: Ismawi, Hidayatul Radziah, Abdul Razak, Tariq, Jamani, Nurjasmine Aida, Mohd Zainudin, Maizura
Format: Article
Language:English
English
Published: Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia 2019
Subjects:
R Medicine (General)
RC Internal medicine
RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System
Online Access:http://irep.iium.edu.my/74406/
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http://irep.iium.edu.my/74406/1/74406_Periodic%20assessment%20of%20antenatal%20and%20post%20natal%20serum%20Endothelin-1%20%28ET-1%29%20and%20nitric%20oxide%20%28NO%29%20levels%20in%20Hypertensive%20Disorders%20of%20Pregnancy%20%28HDP%29.pdf
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spelling iium-744062019-11-19T06:37:39Z http://irep.iium.edu.my/74406/ Periodic assessment of antenatal and post natal serum endothelin-1 (ET-1) and nitric oxide (NO) levels in hypertensive disorders of pregnancy (HDP) Ismawi, Hidayatul Radziah Abdul Razak, Tariq Jamani, Nurjasmine Aida Mohd Zainudin, Maizura R Medicine (General) RC Internal medicine RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System Introduction: Hypertensive Disorders of Pregnancy (HDP) is an independent risk factor of cardiovascular (CVS) disease with endothelial dysfunction postulated to be the pathophysiology. Endothelin-1 (ET-1), a potent vasoconstrictor, has been identified as a pivotal mediator in HDP. Disturbances in nitric oxide (NO) bioavailability found in endothelial dysfunction may increase susceptibility to cardiovascular diseases such as hypertension. The study aims to determine serial ET-1 and NO levels in patients with HDP and its role in persistent endothelial dysfunction. Materials and Methods: Thirty-six pregnant women from the following categories (i) normal pregnant women (Control) (ii) chronic hypertension during pregnancy (CH) and (iii) pregnancy induced hypertension (PIH) participated in this study. Blood pressure indices measurements and sample collection were done at antepartum (32 weeks) and postpartum (8 weeks and 12 weeks). ET-1 and serum NO were measured using the Human ET-1 (Endothelin-1) ELISA Kit and Nitric Oxide (total) detection kit respectively. Results: Serum ET-1 was significantly higher in patients with CH (55.3 pg/ml) and PIH (35.6 pg/ml) compared to Control (11.8 pg/ml) during antenatal until 3 months postpartum (CH 38.3 pg/ml, PIH 29.5 pg/ml, Control 1.9 pg/ml). This was accompanied by significantly lower levels of serum NO in HDP patients. Conclusion: Persistently higher than normal levels of ET-1 and lower than normal levels of NO up to 3 months postpartum in patients with history of HDP indicate presence of persistent endothelial dysfunction despite BP normalisation in PIH patients. Long term NO/ET-1 imbalance may account for the increased CVS disease risk. Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia 2019-08 Article PeerReviewed application/pdf en http://irep.iium.edu.my/74406/1/74406_Periodic%20assessment%20of%20antenatal%20and%20post%20natal%20serum%20Endothelin-1%20%28ET-1%29%20and%20nitric%20oxide%20%28NO%29%20levels%20in%20Hypertensive%20Disorders%20of%20Pregnancy%20%28HDP%29.pdf application/pdf en http://irep.iium.edu.my/74406/2/74406_Periodic%20assessment%20of%20antenatal%20and%20post%20natal%20serum%20Endothelin-1%20%28ET-1%29%20and%20nitric%20oxide%20%28NO%29%20levels%20in%20Hypertensive%20Disorders%20of%20Pregnancy%20%28HDP%29_SCOPUS.pdf Ismawi, Hidayatul Radziah and Abdul Razak, Tariq and Jamani, Nurjasmine Aida and Mohd Zainudin, Maizura (2019) Periodic assessment of antenatal and post natal serum endothelin-1 (ET-1) and nitric oxide (NO) levels in hypertensive disorders of pregnancy (HDP). International Medical Journal Malaysia, 18 (2). pp. 101-106. E-ISSN 1823-4631 http://iiumedic.net/imjm/v1/download/volume_18_no_2/Pages-from-IMJMVol18No2-16.pdf
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
English
topic R Medicine (General)
RC Internal medicine
RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System
spellingShingle R Medicine (General)
RC Internal medicine
RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System
Ismawi, Hidayatul Radziah
Abdul Razak, Tariq
Jamani, Nurjasmine Aida
Mohd Zainudin, Maizura
Periodic assessment of antenatal and post natal serum endothelin-1 (ET-1) and nitric oxide (NO) levels in hypertensive disorders of pregnancy (HDP)
description Introduction: Hypertensive Disorders of Pregnancy (HDP) is an independent risk factor of cardiovascular (CVS) disease with endothelial dysfunction postulated to be the pathophysiology. Endothelin-1 (ET-1), a potent vasoconstrictor, has been identified as a pivotal mediator in HDP. Disturbances in nitric oxide (NO) bioavailability found in endothelial dysfunction may increase susceptibility to cardiovascular diseases such as hypertension. The study aims to determine serial ET-1 and NO levels in patients with HDP and its role in persistent endothelial dysfunction. Materials and Methods: Thirty-six pregnant women from the following categories (i) normal pregnant women (Control) (ii) chronic hypertension during pregnancy (CH) and (iii) pregnancy induced hypertension (PIH) participated in this study. Blood pressure indices measurements and sample collection were done at antepartum (32 weeks) and postpartum (8 weeks and 12 weeks). ET-1 and serum NO were measured using the Human ET-1 (Endothelin-1) ELISA Kit and Nitric Oxide (total) detection kit respectively. Results: Serum ET-1 was significantly higher in patients with CH (55.3 pg/ml) and PIH (35.6 pg/ml) compared to Control (11.8 pg/ml) during antenatal until 3 months postpartum (CH 38.3 pg/ml, PIH 29.5 pg/ml, Control 1.9 pg/ml). This was accompanied by significantly lower levels of serum NO in HDP patients. Conclusion: Persistently higher than normal levels of ET-1 and lower than normal levels of NO up to 3 months postpartum in patients with history of HDP indicate presence of persistent endothelial dysfunction despite BP normalisation in PIH patients. Long term NO/ET-1 imbalance may account for the increased CVS disease risk.
format Article
author Ismawi, Hidayatul Radziah
Abdul Razak, Tariq
Jamani, Nurjasmine Aida
Mohd Zainudin, Maizura
author_facet Ismawi, Hidayatul Radziah
Abdul Razak, Tariq
Jamani, Nurjasmine Aida
Mohd Zainudin, Maizura
author_sort Ismawi, Hidayatul Radziah
title Periodic assessment of antenatal and post natal serum endothelin-1 (ET-1) and nitric oxide (NO) levels in hypertensive disorders of pregnancy (HDP)
title_short Periodic assessment of antenatal and post natal serum endothelin-1 (ET-1) and nitric oxide (NO) levels in hypertensive disorders of pregnancy (HDP)
title_full Periodic assessment of antenatal and post natal serum endothelin-1 (ET-1) and nitric oxide (NO) levels in hypertensive disorders of pregnancy (HDP)
title_fullStr Periodic assessment of antenatal and post natal serum endothelin-1 (ET-1) and nitric oxide (NO) levels in hypertensive disorders of pregnancy (HDP)
title_full_unstemmed Periodic assessment of antenatal and post natal serum endothelin-1 (ET-1) and nitric oxide (NO) levels in hypertensive disorders of pregnancy (HDP)
title_sort periodic assessment of antenatal and post natal serum endothelin-1 (et-1) and nitric oxide (no) levels in hypertensive disorders of pregnancy (hdp)
publisher Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia
publishDate 2019
url http://irep.iium.edu.my/74406/
http://irep.iium.edu.my/74406/
http://irep.iium.edu.my/74406/1/74406_Periodic%20assessment%20of%20antenatal%20and%20post%20natal%20serum%20Endothelin-1%20%28ET-1%29%20and%20nitric%20oxide%20%28NO%29%20levels%20in%20Hypertensive%20Disorders%20of%20Pregnancy%20%28HDP%29.pdf
http://irep.iium.edu.my/74406/2/74406_Periodic%20assessment%20of%20antenatal%20and%20post%20natal%20serum%20Endothelin-1%20%28ET-1%29%20and%20nitric%20oxide%20%28NO%29%20levels%20in%20Hypertensive%20Disorders%20of%20Pregnancy%20%28HDP%29_SCOPUS.pdf
first_indexed 2023-09-18T21:45:22Z
last_indexed 2023-09-18T21:45:22Z
_version_ 1777413413860802560

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