IgE-mediated hypersensitivity to chlorhexidine among first- year dental students

Purpose To investigate immunoglobulin E (IgE)-medi- ated hypersensitivity to chlorhexidine (CHX), and as- sociation between CHX exposure and serum specific IgE (SIgE) levels, among first-year dental students. Methods Participants completed a questionnaire on medical health, history of allergies/hype...

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Main Authors:	Mohamed Khazin, Sobrina, Abdullah, Dalia, Liew, Amy Kia Cheen, Harun, Nor Adilah, Abdullah, Noormalin, Bun, Can Chong
Format:	Article
Language:	English English English
Published:	Springer Medizin 2019
Subjects:	RK Dentistry RL Dermatology
Online Access:	http://irep.iium.edu.my/74563/ http://irep.iium.edu.my/74563/ http://irep.iium.edu.my/74563/ http://irep.iium.edu.my/74563/1/74563_IgE-mediated%20hypersensitivity%20to%20chlorhexidine.pdf http://irep.iium.edu.my/74563/2/74563_IgE-mediated%20hypersensitivity%20to%20chlorhexidine_MYRA.pdf http://irep.iium.edu.my/74563/3/74563_IgE-mediated%20hypersensitivity%20to%20chlorhexidine_SCOPUS.pdf

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spelling	iium-745632020-03-19T07:49:52Z http://irep.iium.edu.my/74563/ IgE-mediated hypersensitivity to chlorhexidine among first- year dental students Mohamed Khazin, Sobrina Abdullah, Dalia Liew, Amy Kia Cheen Harun, Nor Adilah Abdullah, Noormalin Bun, Can Chong RK Dentistry RL Dermatology Purpose To investigate immunoglobulin E (IgE)-medi- ated hypersensitivity to chlorhexidine (CHX), and as- sociation between CHX exposure and serum specific IgE (SIgE) levels, among first-year dental students. Methods Participants completed a questionnaire on medical health, history of allergies/hypersensitivities and CHX exposure. A sample of venous blood (3mL) was drawn and subjected to SIgE test to CHX; sensiti- sation defined as SIgE level of ≥0.10 kUA/L. Results Fifty-eight (98.3%) participants, consisting of 69% (n=40) female with a mean age of 21, were recruited; three quarters (84%) reported no known health issue, and over half had no history of allergies (57%); less than 20% reported having had exposure to CHX-containing products with the majority from toothpaste (9%) and mouthwash (12%). The CHX SIgE test showed that 8.6% (n = 5) were sensitised. No association between CHX exposure history and the level of SIgE antibody was noted. Conclusions Although most participants reported no known exposure to CHX, 8.6% showed CHX sensitisa- tion suggesting unknown exposure and the potential risk of developing hypersensitivity and adverse reac- tions in the future. Springer Medizin 2019-09-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/74563/1/74563_IgE-mediated%20hypersensitivity%20to%20chlorhexidine.pdf application/pdf en http://irep.iium.edu.my/74563/2/74563_IgE-mediated%20hypersensitivity%20to%20chlorhexidine_MYRA.pdf application/pdf en http://irep.iium.edu.my/74563/3/74563_IgE-mediated%20hypersensitivity%20to%20chlorhexidine_SCOPUS.pdf Mohamed Khazin, Sobrina and Abdullah, Dalia and Liew, Amy Kia Cheen and Harun, Nor Adilah and Abdullah, Noormalin and Bun, Can Chong (2019) IgE-mediated hypersensitivity to chlorhexidine among first- year dental students. Allergo Journal International, 28 (6). pp. 204-208. E-ISSN 2197-0378 https://doi.org/10.1007/s40629-019-0103-5 10.1007/s40629-019-0103-5
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	RK Dentistry RL Dermatology
spellingShingle	RK Dentistry RL Dermatology Mohamed Khazin, Sobrina Abdullah, Dalia Liew, Amy Kia Cheen Harun, Nor Adilah Abdullah, Noormalin Bun, Can Chong IgE-mediated hypersensitivity to chlorhexidine among first- year dental students
description	Purpose To investigate immunoglobulin E (IgE)-medi- ated hypersensitivity to chlorhexidine (CHX), and as- sociation between CHX exposure and serum specific IgE (SIgE) levels, among first-year dental students. Methods Participants completed a questionnaire on medical health, history of allergies/hypersensitivities and CHX exposure. A sample of venous blood (3mL) was drawn and subjected to SIgE test to CHX; sensiti- sation defined as SIgE level of ≥0.10 kUA/L. Results Fifty-eight (98.3%) participants, consisting of 69% (n=40) female with a mean age of 21, were recruited; three quarters (84%) reported no known health issue, and over half had no history of allergies (57%); less than 20% reported having had exposure to CHX-containing products with the majority from toothpaste (9%) and mouthwash (12%). The CHX SIgE test showed that 8.6% (n = 5) were sensitised. No association between CHX exposure history and the level of SIgE antibody was noted. Conclusions Although most participants reported no known exposure to CHX, 8.6% showed CHX sensitisa- tion suggesting unknown exposure and the potential risk of developing hypersensitivity and adverse reac- tions in the future.
format	Article
author	Mohamed Khazin, Sobrina Abdullah, Dalia Liew, Amy Kia Cheen Harun, Nor Adilah Abdullah, Noormalin Bun, Can Chong
author_facet	Mohamed Khazin, Sobrina Abdullah, Dalia Liew, Amy Kia Cheen Harun, Nor Adilah Abdullah, Noormalin Bun, Can Chong
author_sort	Mohamed Khazin, Sobrina
title	IgE-mediated hypersensitivity to chlorhexidine among first- year dental students
title_short	IgE-mediated hypersensitivity to chlorhexidine among first- year dental students
title_full	IgE-mediated hypersensitivity to chlorhexidine among first- year dental students
title_fullStr	IgE-mediated hypersensitivity to chlorhexidine among first- year dental students
title_full_unstemmed	IgE-mediated hypersensitivity to chlorhexidine among first- year dental students
title_sort	ige-mediated hypersensitivity to chlorhexidine among first- year dental students
publisher	Springer Medizin
publishDate	2019
url	http://irep.iium.edu.my/74563/ http://irep.iium.edu.my/74563/ http://irep.iium.edu.my/74563/ http://irep.iium.edu.my/74563/1/74563_IgE-mediated%20hypersensitivity%20to%20chlorhexidine.pdf http://irep.iium.edu.my/74563/2/74563_IgE-mediated%20hypersensitivity%20to%20chlorhexidine_MYRA.pdf http://irep.iium.edu.my/74563/3/74563_IgE-mediated%20hypersensitivity%20to%20chlorhexidine_SCOPUS.pdf
first_indexed	2023-09-18T21:45:33Z
last_indexed	2023-09-18T21:45:33Z
_version_	1777413425597513728

IgE-mediated hypersensitivity to chlorhexidine among first- year dental students

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