Tomato leaves methanol extract posses anti-inflammatory activity via inhibition of Lipopolysacharide (LPS)-induced Prostaglandin (PGE2)
Recently, the leaves of tomato plant that contained several active compound including alkaloid, steroid and flavanoid has been used for treatment of variety of diseases included anticancer, anti-oxidant and anti-gout. Although a number of pharmacological properties have already been demonstrat...
| Main Authors: | , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
2011
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/7469/ http://irep.iium.edu.my/7469/ http://irep.iium.edu.my/7469/1/irep.iium.edu.my_7469.pdf |
| Summary: | Recently, the leaves of tomato plant that contained
several active compound including alkaloid, steroid and flavanoid
has been used for treatment of variety of diseases included anticancer, anti-oxidant and anti-gout. Although a number of
pharmacological properties have already been demonstrated, the
anti-inflammatory effect of tomato leaves action and its
associated molecular mechanisms have not yet been fully
investigated. In this study, in order to observe the antiinflammatory action of Solanum lycopersicum extract on
lipopolysaccharide (LPS)-stimulated macrophages, its inhibitory
of inflammation activity was investigated by observing the
Prostaglandin E2 (PGE2
) production using PGE2 enzyme
immunometric assay kit (Cayman CO., Ann Arbor, MI, USA).
Results showed that the tomato leaves extract inhibited the
productions of inflammatory mediators (PGE2
) which plays a
central role in the anti-inflammatory activity. At the highest
concentration (100µg/ml) of tomato leaves extract tested, the
PGE2 production was reduced 37.41% compared to the
untreated. The COX-2 gene expression also reduced
following increment in the extract concentration.
Hence, these present study may support that the leaves of
Solanum lycopersicum extract potentially use in treatment of
inflammatory related disease through the inhibition of PGE2
releases. |
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