Fatty acid evaluation and antimicrobial activity of virgin coconut oil and activated virgin coconut oil on streptococcus mutans

For decades, coconut oil was reported to possess a broad spectrum of antimicrobial activity due to its abundant fatty acid’s contents. Streptococcus mutans (S. mutans) has been strongly implicated as the main etiological factor in dental caries. Regardless of the ongoing medical advances, the therap...

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Main Authors:	Haron, Ummi Aqilah, Mukhtar, Nor Izzah, Omar, Muhammad Nor, Abllah, Zurainie
Format:	Article
Language:	English English English
Published:	Penerbit Universiti Sains Malaysia 2019
Subjects:	RK318 Oral and Dental Medicine. Pathology. Diseases-Therapeutics-General Works
Online Access:	http://irep.iium.edu.my/74837/ http://irep.iium.edu.my/74837/ http://irep.iium.edu.my/74837/ http://irep.iium.edu.my/74837/1/74837_Fatty%20acid%20evaluation%20and%20antimicrobial%20activity_article.pdf http://irep.iium.edu.my/74837/2/74837_Fatty%20acid%20evaluation%20and%20antimicrobial%20activity_scopus.pdf http://irep.iium.edu.my/74837/3/74837_Fatty%20acid%20evaluation%20and%20antimicrobial%20activity_wos.pdf

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spelling	iium-748372020-03-06T03:50:52Z http://irep.iium.edu.my/74837/ Fatty acid evaluation and antimicrobial activity of virgin coconut oil and activated virgin coconut oil on streptococcus mutans Haron, Ummi Aqilah Mukhtar, Nor Izzah Omar, Muhammad Nor Abllah, Zurainie RK318 Oral and Dental Medicine. Pathology. Diseases-Therapeutics-General Works For decades, coconut oil was reported to possess a broad spectrum of antimicrobial activity due to its abundant fatty acid’s contents. Streptococcus mutans (S. mutans) has been strongly implicated as the main etiological factor in dental caries. Regardless of the ongoing medical advances, the therapeutic resources for dental caries remain ineffectual, and this has led to renewed interest in using virgin coconut oil (VCO) as a possible choice for dental caries control. In this study, the ability of VCO and activated virgin coconut oil (AVCO) combatting cariogenic S. mutans ATCC 25175 has been evaluated. Fatty acids contents were compared through Gas Chromatography-Mass Spectrum (GC-MS) analysis, and their antimicrobial activity was determined using disc diffusion and minimum inhibitory concentration (MIC) test. From the GC-MS analysis, AVCO (59%) was found to have a slightly higher medium-chain fatty acids (MCFA) as compared to VCO (54.1%), and the long-chain fatty acids (LCFA) contents in VCO (45.9%) was found to be higher than AVCO (41%). Interestingly, S. mutans ATCC 25175 was found to be susceptible towards AVCO (MIC: 6.24 mg/ml) and resistance towards VCO in vitro. The excellent antimicrobial activity of AVCO as a result from (i) the release of individuals fatty acids after activation of virgin coconut oil by lipase digestion and (ii) the present of MCFA and LCFA that are significant in antimicrobial activity. Further study can be designed to specifically examine the activity of individuals fatty acids present in oils against S.mutans virulence genes/protein using molecular dynamic assessment. Penerbit Universiti Sains Malaysia 2019-12-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/74837/1/74837_Fatty%20acid%20evaluation%20and%20antimicrobial%20activity_article.pdf application/pdf en http://irep.iium.edu.my/74837/2/74837_Fatty%20acid%20evaluation%20and%20antimicrobial%20activity_scopus.pdf application/pdf en http://irep.iium.edu.my/74837/3/74837_Fatty%20acid%20evaluation%20and%20antimicrobial%20activity_wos.pdf Haron, Ummi Aqilah and Mukhtar, Nor Izzah and Omar, Muhammad Nor and Abllah, Zurainie (2019) Fatty acid evaluation and antimicrobial activity of virgin coconut oil and activated virgin coconut oil on streptococcus mutans. Archives of Orofacial Sciences, 14 (2). pp. 87-98. ISSN 1823-8602 E-ISSN 2231-7163 http://aos.usm.my/docs/Vol_14/aos-article-359.pdf 10.21315/aos2019.14.2.359
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	RK318 Oral and Dental Medicine. Pathology. Diseases-Therapeutics-General Works
spellingShingle	RK318 Oral and Dental Medicine. Pathology. Diseases-Therapeutics-General Works Haron, Ummi Aqilah Mukhtar, Nor Izzah Omar, Muhammad Nor Abllah, Zurainie Fatty acid evaluation and antimicrobial activity of virgin coconut oil and activated virgin coconut oil on streptococcus mutans
description	For decades, coconut oil was reported to possess a broad spectrum of antimicrobial activity due to its abundant fatty acid’s contents. Streptococcus mutans (S. mutans) has been strongly implicated as the main etiological factor in dental caries. Regardless of the ongoing medical advances, the therapeutic resources for dental caries remain ineffectual, and this has led to renewed interest in using virgin coconut oil (VCO) as a possible choice for dental caries control. In this study, the ability of VCO and activated virgin coconut oil (AVCO) combatting cariogenic S. mutans ATCC 25175 has been evaluated. Fatty acids contents were compared through Gas Chromatography-Mass Spectrum (GC-MS) analysis, and their antimicrobial activity was determined using disc diffusion and minimum inhibitory concentration (MIC) test. From the GC-MS analysis, AVCO (59%) was found to have a slightly higher medium-chain fatty acids (MCFA) as compared to VCO (54.1%), and the long-chain fatty acids (LCFA) contents in VCO (45.9%) was found to be higher than AVCO (41%). Interestingly, S. mutans ATCC 25175 was found to be susceptible towards AVCO (MIC: 6.24 mg/ml) and resistance towards VCO in vitro. The excellent antimicrobial activity of AVCO as a result from (i) the release of individuals fatty acids after activation of virgin coconut oil by lipase digestion and (ii) the present of MCFA and LCFA that are significant in antimicrobial activity. Further study can be designed to specifically examine the activity of individuals fatty acids present in oils against S.mutans virulence genes/protein using molecular dynamic assessment.
format	Article
author	Haron, Ummi Aqilah Mukhtar, Nor Izzah Omar, Muhammad Nor Abllah, Zurainie
author_facet	Haron, Ummi Aqilah Mukhtar, Nor Izzah Omar, Muhammad Nor Abllah, Zurainie
author_sort	Haron, Ummi Aqilah
title	Fatty acid evaluation and antimicrobial activity of virgin coconut oil and activated virgin coconut oil on streptococcus mutans
title_short	Fatty acid evaluation and antimicrobial activity of virgin coconut oil and activated virgin coconut oil on streptococcus mutans
title_full	Fatty acid evaluation and antimicrobial activity of virgin coconut oil and activated virgin coconut oil on streptococcus mutans
title_fullStr	Fatty acid evaluation and antimicrobial activity of virgin coconut oil and activated virgin coconut oil on streptococcus mutans
title_full_unstemmed	Fatty acid evaluation and antimicrobial activity of virgin coconut oil and activated virgin coconut oil on streptococcus mutans
title_sort	fatty acid evaluation and antimicrobial activity of virgin coconut oil and activated virgin coconut oil on streptococcus mutans
publisher	Penerbit Universiti Sains Malaysia
publishDate	2019
url	http://irep.iium.edu.my/74837/ http://irep.iium.edu.my/74837/ http://irep.iium.edu.my/74837/ http://irep.iium.edu.my/74837/1/74837_Fatty%20acid%20evaluation%20and%20antimicrobial%20activity_article.pdf http://irep.iium.edu.my/74837/2/74837_Fatty%20acid%20evaluation%20and%20antimicrobial%20activity_scopus.pdf http://irep.iium.edu.my/74837/3/74837_Fatty%20acid%20evaluation%20and%20antimicrobial%20activity_wos.pdf
first_indexed	2023-09-18T21:45:54Z
last_indexed	2023-09-18T21:45:54Z
_version_	1777413447068155904

Fatty acid evaluation and antimicrobial activity of virgin coconut oil and activated virgin coconut oil on streptococcus mutans

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