The antihypertensive efficacy of Piper sarmentosum aqueous extract as compared to perindopril in spontaneously hypertensive rats

Aims/Objective: One of the impediments in overcoming hypertension is treatment failure caused by patient compliance in conventional medicine. Herbal remedies receive less defiance, and thus have been studied considerably. This study aimed to evaluate the efficacy of Piper sarmentosum aqueous extract...

Full description

Bibliographic Details
Main Authors:	Hashim Fauzy, Fatimatuzzahra, Mohd Zainudin, Maizura, Ismawi, Hidayatul Radziah, FT Elshami, Taher
Format:	Conference or Workshop Item
Language:	English English
Published:	2019
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/75226/ http://irep.iium.edu.my/75226/ http://irep.iium.edu.my/75226/19/75226%20The%20antihypertensive%20efficacy.pdf http://irep.iium.edu.my/75226/2/Kucing%20Conference-PSAEORALpdf.pdf

id	iium-75226
recordtype	eprints
spelling	iium-752262019-11-12T07:45:33Z http://irep.iium.edu.my/75226/ The antihypertensive efficacy of Piper sarmentosum aqueous extract as compared to perindopril in spontaneously hypertensive rats Hashim Fauzy, Fatimatuzzahra Mohd Zainudin, Maizura Ismawi, Hidayatul Radziah FT Elshami, Taher R Medicine (General) Aims/Objective: One of the impediments in overcoming hypertension is treatment failure caused by patient compliance in conventional medicine. Herbal remedies receive less defiance, and thus have been studied considerably. This study aimed to evaluate the efficacy of Piper sarmentosum aqueous extract (PSAE) in reducing blood pressure via endothelial dysfunction amelioration as compared to angiotensin-converting-enzyme (ACE) inhibitor, Perindopril. Methods: Blood pressure indices, level of mesenteric artery nitric oxide (NO) and endothelin1 (ET-1) were studied in four different groups (n=6) of spontaneously hypertensive rats (SHR) i.e. i) received distilled water, ii) 3 mg/kg Perindopril, iii) 500 mg/kg PSAE, and iv) a combination of 1.5 mg/kg Perindopril and 500 mg/kg PSAE. The rats were treated for 28 consecutive days, and blood pressure was measured weekly. NO and ET-1 level were analysed at the end of treatment period, after the rats were humanely sacrificed. Results: All three groups that received treatments have significantly lower systolic, diastolic, and mean arterial pressure (P<0.05), as well as higher NO level (P<0.05), and lower ET-1 level (P<0.05) as compared to the group receiving distilled water. However, rats that received Perindopril have the lowest systolic, diastolic, and mean arterial pressure, highest NO level, and lowest ET-1 level, followed by SHR treated by combined therapy and PSAE. Conclusion: Use of PSAE alone in once daily (OD) dose does not demonstrate better outcome than use of conventional Perindopril therapy in hypertensive subject. Further trials are imperative to fully establish the efficacy, tolerability, and possible adjuvant capacity of this potentially therapeutic agent. 2019 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/75226/19/75226%20The%20antihypertensive%20efficacy.pdf application/pdf en http://irep.iium.edu.my/75226/2/Kucing%20Conference-PSAEORALpdf.pdf Hashim Fauzy, Fatimatuzzahra and Mohd Zainudin, Maizura and Ismawi, Hidayatul Radziah and FT Elshami, Taher (2019) The antihypertensive efficacy of Piper sarmentosum aqueous extract as compared to perindopril in spontaneously hypertensive rats. In: The 4th International Conference on Advances in Medical Science (ICAMS 2019), 12th-14th April 2019, Kuching, Sarawak. (Unpublished) https://www.klconference.com/icams2019/sites/default/files/Abstract%20Book%20ICAMS%202019.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Hashim Fauzy, Fatimatuzzahra Mohd Zainudin, Maizura Ismawi, Hidayatul Radziah FT Elshami, Taher The antihypertensive efficacy of Piper sarmentosum aqueous extract as compared to perindopril in spontaneously hypertensive rats
description	Aims/Objective: One of the impediments in overcoming hypertension is treatment failure caused by patient compliance in conventional medicine. Herbal remedies receive less defiance, and thus have been studied considerably. This study aimed to evaluate the efficacy of Piper sarmentosum aqueous extract (PSAE) in reducing blood pressure via endothelial dysfunction amelioration as compared to angiotensin-converting-enzyme (ACE) inhibitor, Perindopril. Methods: Blood pressure indices, level of mesenteric artery nitric oxide (NO) and endothelin1 (ET-1) were studied in four different groups (n=6) of spontaneously hypertensive rats (SHR) i.e. i) received distilled water, ii) 3 mg/kg Perindopril, iii) 500 mg/kg PSAE, and iv) a combination of 1.5 mg/kg Perindopril and 500 mg/kg PSAE. The rats were treated for 28 consecutive days, and blood pressure was measured weekly. NO and ET-1 level were analysed at the end of treatment period, after the rats were humanely sacrificed. Results: All three groups that received treatments have significantly lower systolic, diastolic, and mean arterial pressure (P<0.05), as well as higher NO level (P<0.05), and lower ET-1 level (P<0.05) as compared to the group receiving distilled water. However, rats that received Perindopril have the lowest systolic, diastolic, and mean arterial pressure, highest NO level, and lowest ET-1 level, followed by SHR treated by combined therapy and PSAE. Conclusion: Use of PSAE alone in once daily (OD) dose does not demonstrate better outcome than use of conventional Perindopril therapy in hypertensive subject. Further trials are imperative to fully establish the efficacy, tolerability, and possible adjuvant capacity of this potentially therapeutic agent.
format	Conference or Workshop Item
author	Hashim Fauzy, Fatimatuzzahra Mohd Zainudin, Maizura Ismawi, Hidayatul Radziah FT Elshami, Taher
author_facet	Hashim Fauzy, Fatimatuzzahra Mohd Zainudin, Maizura Ismawi, Hidayatul Radziah FT Elshami, Taher
author_sort	Hashim Fauzy, Fatimatuzzahra
title	The antihypertensive efficacy of Piper sarmentosum aqueous extract as compared to perindopril in spontaneously hypertensive rats
title_short	The antihypertensive efficacy of Piper sarmentosum aqueous extract as compared to perindopril in spontaneously hypertensive rats
title_full	The antihypertensive efficacy of Piper sarmentosum aqueous extract as compared to perindopril in spontaneously hypertensive rats
title_fullStr	The antihypertensive efficacy of Piper sarmentosum aqueous extract as compared to perindopril in spontaneously hypertensive rats
title_full_unstemmed	The antihypertensive efficacy of Piper sarmentosum aqueous extract as compared to perindopril in spontaneously hypertensive rats
title_sort	antihypertensive efficacy of piper sarmentosum aqueous extract as compared to perindopril in spontaneously hypertensive rats
publishDate	2019
url	http://irep.iium.edu.my/75226/ http://irep.iium.edu.my/75226/ http://irep.iium.edu.my/75226/19/75226%20The%20antihypertensive%20efficacy.pdf http://irep.iium.edu.my/75226/2/Kucing%20Conference-PSAEORALpdf.pdf
first_indexed	2023-09-18T21:46:26Z
last_indexed	2023-09-18T21:46:26Z
_version_	1777413481155264512

The antihypertensive efficacy of Piper sarmentosum aqueous extract as compared to perindopril in spontaneously hypertensive rats

Similar Items