Preliminary study in discovering 2-geranylphenol from Lansium domesticum leaves as oxidation and tyrosinase inhibitor for anti-aging and skin whitening agents: experimental and theoretical study

Antioxidant and tyrosinase inhibitor have been recognized as one of the most important ingredients used in cosmetic industries. These ingredients are commonly utilized to counter skin concern faced by middleaged woman regarding aging and hyperpigmentation problems. Phenolic compounds were identified...

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Main Authors:	Abdul Razak, Nur Diana, Abdullah, Erna Normaya, Mat Piah, Mohd Bijarimi, Yunus, Kamaruzzaman, Ahmad, Mohammad Norazmi
Format:	Conference or Workshop Item
Language:	English English
Published:	Universiti Kuala Lumpur Branch Campus Malaysian Institute of Chemical and Bioengineering Technology 2019
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/75323/ http://irep.iium.edu.my/75323/7/75323%20PRELIMINARY%20STUDY%20I.pdf http://irep.iium.edu.my/75323/13/SKAM%20PRESENTATION%20Ahmad%20et%20al.%202019a.pdf

id	iium-75323
recordtype	eprints
spelling	iium-753232019-11-23T20:27:31Z http://irep.iium.edu.my/75323/ Preliminary study in discovering 2-geranylphenol from Lansium domesticum leaves as oxidation and tyrosinase inhibitor for anti-aging and skin whitening agents: experimental and theoretical study Abdul Razak, Nur Diana Abdullah, Erna Normaya Mat Piah, Mohd Bijarimi Yunus, Kamaruzzaman Ahmad, Mohammad Norazmi QD Chemistry Antioxidant and tyrosinase inhibitor have been recognized as one of the most important ingredients used in cosmetic industries. These ingredients are commonly utilized to counter skin concern faced by middleaged woman regarding aging and hyperpigmentation problems. Phenolic compounds were identified to be one of the effective compound that can exert both antioxidant and anti-tyrosinase activities. Therefore, this research sought to identify a novel phenolic compound from Lansium domestium (L. domesticum) leaves as a new potential antioxidant and tyrosinase inhibitors. The phenolic compounds were extracted using supercritical fluid extraction (SFE) technique following the treatment combinations by response surface methodology (RSM) that investigated the possible interaction between three variables which were pressure (2900 - 4300 psi), temperature (40 - 70 ℃) and extraction time (60 - 120 min). The optimized extraction variables were found at 3800 psi, 53 ℃ and 90 min. The overall model was significant (p < 0.05) with satisfactory R 2 value of 0.9997. The combination of GC-MS and PCA method showed several phenolic compounds were present in the L. domesticum leaves extracts and 2-geranylphenol was predicted to be tyrosinase inhibitor because it showed considerable chemical properties with the control, hydroquinone. The antioxidant activity of the extract was evaluated by DPPH radical scavenging assay using different concentration of L. domesticum leaves extracts. The highest antioxidant activity was observed at 300 ppm of the plant extract. The COSMO-RS result also confirmed that the 2-geranylphenol was successfully extracted by using carbon dioxide as solvent. MEP and molecular docking were done to identify and investigate the key structural features of 2-geranylphenol that are important for their activity and the interaction that contribute to tyrosinase inhibition respectively. The overall result showed that 2-geranylphenol has a potential to replace hydroquinone as tyrosinase inhibitor in cosmetic industry. Universiti Kuala Lumpur Branch Campus Malaysian Institute of Chemical and Bioengineering Technology 2019 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/75323/7/75323%20PRELIMINARY%20STUDY%20I.pdf application/pdf en http://irep.iium.edu.my/75323/13/SKAM%20PRESENTATION%20Ahmad%20et%20al.%202019a.pdf Abdul Razak, Nur Diana and Abdullah, Erna Normaya and Mat Piah, Mohd Bijarimi and Yunus, Kamaruzzaman and Ahmad, Mohammad Norazmi (2019) Preliminary study in discovering 2-geranylphenol from Lansium domesticum leaves as oxidation and tyrosinase inhibitor for anti-aging and skin whitening agents: experimental and theoretical study. In: The 32nd Symposium of Malaysia Analytical Sciences : Simposium KImia Analisis Malaysia (SKAM 32), 14th-16th August 2019, Port Dickson, Negeri Sembilan.
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QD Chemistry
spellingShingle	QD Chemistry Abdul Razak, Nur Diana Abdullah, Erna Normaya Mat Piah, Mohd Bijarimi Yunus, Kamaruzzaman Ahmad, Mohammad Norazmi Preliminary study in discovering 2-geranylphenol from Lansium domesticum leaves as oxidation and tyrosinase inhibitor for anti-aging and skin whitening agents: experimental and theoretical study
description	Antioxidant and tyrosinase inhibitor have been recognized as one of the most important ingredients used in cosmetic industries. These ingredients are commonly utilized to counter skin concern faced by middleaged woman regarding aging and hyperpigmentation problems. Phenolic compounds were identified to be one of the effective compound that can exert both antioxidant and anti-tyrosinase activities. Therefore, this research sought to identify a novel phenolic compound from Lansium domestium (L. domesticum) leaves as a new potential antioxidant and tyrosinase inhibitors. The phenolic compounds were extracted using supercritical fluid extraction (SFE) technique following the treatment combinations by response surface methodology (RSM) that investigated the possible interaction between three variables which were pressure (2900 - 4300 psi), temperature (40 - 70 ℃) and extraction time (60 - 120 min). The optimized extraction variables were found at 3800 psi, 53 ℃ and 90 min. The overall model was significant (p < 0.05) with satisfactory R 2 value of 0.9997. The combination of GC-MS and PCA method showed several phenolic compounds were present in the L. domesticum leaves extracts and 2-geranylphenol was predicted to be tyrosinase inhibitor because it showed considerable chemical properties with the control, hydroquinone. The antioxidant activity of the extract was evaluated by DPPH radical scavenging assay using different concentration of L. domesticum leaves extracts. The highest antioxidant activity was observed at 300 ppm of the plant extract. The COSMO-RS result also confirmed that the 2-geranylphenol was successfully extracted by using carbon dioxide as solvent. MEP and molecular docking were done to identify and investigate the key structural features of 2-geranylphenol that are important for their activity and the interaction that contribute to tyrosinase inhibition respectively. The overall result showed that 2-geranylphenol has a potential to replace hydroquinone as tyrosinase inhibitor in cosmetic industry.
format	Conference or Workshop Item
author	Abdul Razak, Nur Diana Abdullah, Erna Normaya Mat Piah, Mohd Bijarimi Yunus, Kamaruzzaman Ahmad, Mohammad Norazmi
author_facet	Abdul Razak, Nur Diana Abdullah, Erna Normaya Mat Piah, Mohd Bijarimi Yunus, Kamaruzzaman Ahmad, Mohammad Norazmi
author_sort	Abdul Razak, Nur Diana
title	Preliminary study in discovering 2-geranylphenol from Lansium domesticum leaves as oxidation and tyrosinase inhibitor for anti-aging and skin whitening agents: experimental and theoretical study
title_short	Preliminary study in discovering 2-geranylphenol from Lansium domesticum leaves as oxidation and tyrosinase inhibitor for anti-aging and skin whitening agents: experimental and theoretical study
title_full	Preliminary study in discovering 2-geranylphenol from Lansium domesticum leaves as oxidation and tyrosinase inhibitor for anti-aging and skin whitening agents: experimental and theoretical study
title_fullStr	Preliminary study in discovering 2-geranylphenol from Lansium domesticum leaves as oxidation and tyrosinase inhibitor for anti-aging and skin whitening agents: experimental and theoretical study
title_full_unstemmed	Preliminary study in discovering 2-geranylphenol from Lansium domesticum leaves as oxidation and tyrosinase inhibitor for anti-aging and skin whitening agents: experimental and theoretical study
title_sort	preliminary study in discovering 2-geranylphenol from lansium domesticum leaves as oxidation and tyrosinase inhibitor for anti-aging and skin whitening agents: experimental and theoretical study
publisher	Universiti Kuala Lumpur Branch Campus Malaysian Institute of Chemical and Bioengineering Technology
publishDate	2019
url	http://irep.iium.edu.my/75323/ http://irep.iium.edu.my/75323/7/75323%20PRELIMINARY%20STUDY%20I.pdf http://irep.iium.edu.my/75323/13/SKAM%20PRESENTATION%20Ahmad%20et%20al.%202019a.pdf
first_indexed	2023-09-18T21:46:35Z
last_indexed	2023-09-18T21:46:35Z
_version_	1777413490324013056

Preliminary study in discovering 2-geranylphenol from Lansium domesticum leaves as oxidation and tyrosinase inhibitor for anti-aging and skin whitening agents: experimental and theoretical study

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