Effects of Eurycoma longifolia jack (Tongkat Ali) alcoholic root extract against oral pathogens
Introduction: Eurycoma longifolia jack (E.L) is a herbal medicinal plant of South-East Asian origin, popularly recognized as ‘Tongkat Ali.’ The plant roots have been scientifically proven to have many biological effects including antibacterial activity however, no previous research to date has st...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
2019
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/75384/ http://irep.iium.edu.my/75384/ http://irep.iium.edu.my/75384/ http://irep.iium.edu.my/75384/7/75384%20Effects%20of%20Eurycoma%20Longifolia%20Jack.pdf http://irep.iium.edu.my/75384/8/75384%20Effects%20of%20Eurycoma%20Longifolia%20Jack%20SCOPUS.pdf |
| Summary: | Introduction: Eurycoma longifolia jack (E.L) is a herbal medicinal plant of South-East Asian
origin, popularly recognized as ‘Tongkat Ali.’ The plant roots have been scientifically proven
to have many biological effects including antibacterial activity however, no previous research
to date has studied the effect on oral pathogens including cariogenic bacteria. This study
was done to determine the antibacterial and antifungal activities of E.L. root extract against
three common oral pathogens. Material and Methods: The microorganisms used were
Candida albicans, Streptococcus mutans and Lactobacillus casei. E.L root was extracted
using soxhlet method. Disc diffusion assay was conducted using extract concentration of
200 mg/ml. Nystatin and Ampicillin were used as positive control for fungal and bacterial
tests respectively. Minimum Inhibitory Concentration (MIC) was done to determine the lowest
inhibitory concentration of the extract on the microorganisms. Results: E.L extract inhibited
the growth of Candida albicans and Streptococcus mutans at a concentration of 200 mg/
ml with a zone of inhibition of 16.0 ± 3.0 mm and 7.0 ± 1.0 mm respectively. There was no
antimicrobial effect of the extract on Lactobacillus casei. The MIC of E.L extract against both
Candida albicans and Streptococcus mutans was 25 mg/ml. Conclusions: The results from
this study revealed the potential use of Eurycoma longifolia jack as an antimicrobial agent
which can be used to produce new oral care products. |
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