Blood pressure lowering mechanisms of Kadukmy™ in essential hypertension

The National Health and Morbidity Survey 2011 estimated that almost half (43.5%) of Malaysian adults aged 30 and older suffer from the multifactorial disease of hypertension. Studies have shown that oxidative stress and low availability of nitric oxide (NO) result in endothelial dysfunction resultin...

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Main Authors:	Mohd Zainudin, Maizura, Ismawi, Hidayatul Radziah, Abdul Razak, Tariq, Jamani, Nurjasmine Aida, Daraup, Salmi
Format:	Monograph
Language:	English
Published:	Hindawi 2019
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/75443/ http://irep.iium.edu.my/75443/ http://irep.iium.edu.my/75443/ http://irep.iium.edu.my/75443/2/MAY2019Profile%20of%20Final%20Report_FRGS-RAGS_ERGS_PRGS%20April%202017.pdf

id	iium-75443
recordtype	eprints
spelling	iium-754432019-10-23T07:16:51Z http://irep.iium.edu.my/75443/ Blood pressure lowering mechanisms of Kadukmy™ in essential hypertension Mohd Zainudin, Maizura Ismawi, Hidayatul Radziah Abdul Razak, Tariq Jamani, Nurjasmine Aida Daraup, Salmi R Medicine (General) The National Health and Morbidity Survey 2011 estimated that almost half (43.5%) of Malaysian adults aged 30 and older suffer from the multifactorial disease of hypertension. Studies have shown that oxidative stress and low availability of nitric oxide (NO) result in endothelial dysfunction resulting in increase of vasoactive factors such as endothelin 1 (ET 1) and Angiotensin II (Ang II), resulting in blood pressure elevation. Piper sarmentosum (PS) is a traditional Malay herbal plant known for its high total phenolic and flavonoid content. Our previous studies with Kadukmy™, our patented formulation of PS extract, have shown that its active compounds rich in antioxidant properties does not cause subacute toxicity in the haematological profile, liver and kidney in spontaneously hypertensive rats (SHRs). Our previous studies with Kadukmy™ have revealed its blood pressure lowering effects, although the exact mechanism is yet to be established. Thus, this study hopes to identify the anti-hypertensive mechanism of Kadukmy™ supplementation on the various blood pressure regulating pathways associated with the pathogenesis of essential hypertension using the Spontaneous Hypertensive Rat (SHR) model. SHR rats will be divided into 2 control groups and 2 treatment groups (Kadukmy™, Kadukmy™ + Perindopril). Blood pressure indices, biochemical levels and proteomic studies will be conducted to determine Kadukmy mechanism of action. It is hoped that the findings will provide scientific support for the patented Kadukmy to be used in hypertensive patients and encourage the culture of evidence-based medicine with local plants. Hindawi 2019-08-14 Monograph NonPeerReviewed application/pdf en http://irep.iium.edu.my/75443/2/MAY2019Profile%20of%20Final%20Report_FRGS-RAGS_ERGS_PRGS%20April%202017.pdf Mohd Zainudin, Maizura and Ismawi, Hidayatul Radziah and Abdul Razak, Tariq and Jamani, Nurjasmine Aida and Daraup, Salmi (2019) Blood pressure lowering mechanisms of Kadukmy™ in essential hypertension. Research Report. Hindawi, London. https://doi.org/10.1155/2019/7198592 7198592
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Mohd Zainudin, Maizura Ismawi, Hidayatul Radziah Abdul Razak, Tariq Jamani, Nurjasmine Aida Daraup, Salmi Blood pressure lowering mechanisms of Kadukmy™ in essential hypertension
description	The National Health and Morbidity Survey 2011 estimated that almost half (43.5%) of Malaysian adults aged 30 and older suffer from the multifactorial disease of hypertension. Studies have shown that oxidative stress and low availability of nitric oxide (NO) result in endothelial dysfunction resulting in increase of vasoactive factors such as endothelin 1 (ET 1) and Angiotensin II (Ang II), resulting in blood pressure elevation. Piper sarmentosum (PS) is a traditional Malay herbal plant known for its high total phenolic and flavonoid content. Our previous studies with Kadukmy™, our patented formulation of PS extract, have shown that its active compounds rich in antioxidant properties does not cause subacute toxicity in the haematological profile, liver and kidney in spontaneously hypertensive rats (SHRs). Our previous studies with Kadukmy™ have revealed its blood pressure lowering effects, although the exact mechanism is yet to be established. Thus, this study hopes to identify the anti-hypertensive mechanism of Kadukmy™ supplementation on the various blood pressure regulating pathways associated with the pathogenesis of essential hypertension using the Spontaneous Hypertensive Rat (SHR) model. SHR rats will be divided into 2 control groups and 2 treatment groups (Kadukmy™, Kadukmy™ + Perindopril). Blood pressure indices, biochemical levels and proteomic studies will be conducted to determine Kadukmy mechanism of action. It is hoped that the findings will provide scientific support for the patented Kadukmy to be used in hypertensive patients and encourage the culture of evidence-based medicine with local plants.
format	Monograph
author	Mohd Zainudin, Maizura Ismawi, Hidayatul Radziah Abdul Razak, Tariq Jamani, Nurjasmine Aida Daraup, Salmi
author_facet	Mohd Zainudin, Maizura Ismawi, Hidayatul Radziah Abdul Razak, Tariq Jamani, Nurjasmine Aida Daraup, Salmi
author_sort	Mohd Zainudin, Maizura
title	Blood pressure lowering mechanisms of Kadukmy™ in essential hypertension
title_short	Blood pressure lowering mechanisms of Kadukmy™ in essential hypertension
title_full	Blood pressure lowering mechanisms of Kadukmy™ in essential hypertension
title_fullStr	Blood pressure lowering mechanisms of Kadukmy™ in essential hypertension
title_full_unstemmed	Blood pressure lowering mechanisms of Kadukmy™ in essential hypertension
title_sort	blood pressure lowering mechanisms of kadukmy™ in essential hypertension
publisher	Hindawi
publishDate	2019
url	http://irep.iium.edu.my/75443/ http://irep.iium.edu.my/75443/ http://irep.iium.edu.my/75443/ http://irep.iium.edu.my/75443/2/MAY2019Profile%20of%20Final%20Report_FRGS-RAGS_ERGS_PRGS%20April%202017.pdf
first_indexed	2023-09-18T21:46:45Z
last_indexed	2023-09-18T21:46:45Z
_version_	1777413501026828288

Blood pressure lowering mechanisms of Kadukmy™ in essential hypertension

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