Screening of electrospray operating parameters in the production of alginate-royal jelly microbeads using factorial design

Introduction: Royal jelly (RJ) has been consumed as food or as a supplement because of its high nutritional and medicinal values. A fresh harvested RJ is yellowish to whitish in colour and contains proteins, free amino acids, lipids, vitamins, and sugar. Without proper storage conditions such as at...

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Main Authors:	Mohd Rus, Shaiqah, Abu Yazid, Anis Afiful Huda, Mohamad, Izzuddin, Noor Ismadi, Muhammad Nur Shafiq, Mohd Azlan, Nur Hakimah, Rahman, Siti Radziah, Doolaanea, Abd Almonem, Adina, Anugerah Budipratama, Haris @ Harith, Muhammad Salahuddin
Format:	Conference or Workshop Item
Language:	English English English
Published:	2019
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/75505/ http://irep.iium.edu.my/75505/1/ICPRP-2019-ALL-Abstracts.pdf http://irep.iium.edu.my/75505/7/Dr%20Solah%20%20Outline.pdf http://irep.iium.edu.my/75505/8/ID%20NO.%2035_LOA%202019.pdf

id	iium-75505
recordtype	eprints
spelling	iium-755052019-11-14T07:29:51Z http://irep.iium.edu.my/75505/ Screening of electrospray operating parameters in the production of alginate-royal jelly microbeads using factorial design Mohd Rus, Shaiqah Abu Yazid, Anis Afiful Huda Mohamad, Izzuddin Noor Ismadi, Muhammad Nur Shafiq Mohd Azlan, Nur Hakimah Rahman, Siti Radziah Doolaanea, Abd Almonem Adina, Anugerah Budipratama Haris @ Harith, Muhammad Salahuddin RS Pharmacy and materia medica Introduction: Royal jelly (RJ) has been consumed as food or as a supplement because of its high nutritional and medicinal values. A fresh harvested RJ is yellowish to whitish in colour and contains proteins, free amino acids, lipids, vitamins, and sugar. Without proper storage conditions such as at 4 °C, RJ’s colour changes to much darker yellow and produces a rancid smell. In order to prolong its shelf life, RJ is usually mixed with honey. Alginate, a natural and edible polymer derived from seaweed is commonly used to encapsulate drugs and food due to its ability to form gels by reacting with divalent cations. However, there is a lack of research on the microencapsulation of RJ in alginate using electrospray. The electrospray technique has the advantage in producing consistent size and shape of alginate microbeads under optimum parameters. Objectives: This research aims to optimize electrospray operating parameters in producing alginate-royal jelly microbeads. Methods: Optimization of alginate-royal jelly microbeads electrospray parameters was done using 24 factorial design with 3 centre points (19 runs). The studied parameters were flow rate, high voltage, nozzle size, and tip-to-collector distance while the responses were particle size, particle size distribution, and sphericity factor. The responses of each run were analysed using Design Expert® software. Results: Nozzle size is a significant parameter that influences the particle size. Flow rate is a significant parameter influencing the sphericity factor. Conclusion: Screening of the electrospray operating parameters paves the way in determining the significant parameters and their design space to produce consistent alginate-RJ microbeads. 2019-10-19 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/75505/1/ICPRP-2019-ALL-Abstracts.pdf application/pdf en http://irep.iium.edu.my/75505/7/Dr%20Solah%20%20Outline.pdf application/pdf en http://irep.iium.edu.my/75505/8/ID%20NO.%2035_LOA%202019.pdf Mohd Rus, Shaiqah and Abu Yazid, Anis Afiful Huda and Mohamad, Izzuddin and Noor Ismadi, Muhammad Nur Shafiq and Mohd Azlan, Nur Hakimah and Rahman, Siti Radziah and Doolaanea, Abd Almonem and Adina, Anugerah Budipratama and Haris @ Harith, Muhammad Salahuddin (2019) Screening of electrospray operating parameters in the production of alginate-royal jelly microbeads using factorial design. In: International Conference on Pharmaceutical Research and Pharmacy Practice cum 14th IIUM-MPS Pharmacy Scientific Conference (ICPRP 2019), 19-20th October 2019, Hotel Istana Kuala Lumpur. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Mohd Rus, Shaiqah Abu Yazid, Anis Afiful Huda Mohamad, Izzuddin Noor Ismadi, Muhammad Nur Shafiq Mohd Azlan, Nur Hakimah Rahman, Siti Radziah Doolaanea, Abd Almonem Adina, Anugerah Budipratama Haris @ Harith, Muhammad Salahuddin Screening of electrospray operating parameters in the production of alginate-royal jelly microbeads using factorial design
description	Introduction: Royal jelly (RJ) has been consumed as food or as a supplement because of its high nutritional and medicinal values. A fresh harvested RJ is yellowish to whitish in colour and contains proteins, free amino acids, lipids, vitamins, and sugar. Without proper storage conditions such as at 4 °C, RJ’s colour changes to much darker yellow and produces a rancid smell. In order to prolong its shelf life, RJ is usually mixed with honey. Alginate, a natural and edible polymer derived from seaweed is commonly used to encapsulate drugs and food due to its ability to form gels by reacting with divalent cations. However, there is a lack of research on the microencapsulation of RJ in alginate using electrospray. The electrospray technique has the advantage in producing consistent size and shape of alginate microbeads under optimum parameters. Objectives: This research aims to optimize electrospray operating parameters in producing alginate-royal jelly microbeads. Methods: Optimization of alginate-royal jelly microbeads electrospray parameters was done using 24 factorial design with 3 centre points (19 runs). The studied parameters were flow rate, high voltage, nozzle size, and tip-to-collector distance while the responses were particle size, particle size distribution, and sphericity factor. The responses of each run were analysed using Design Expert® software. Results: Nozzle size is a significant parameter that influences the particle size. Flow rate is a significant parameter influencing the sphericity factor. Conclusion: Screening of the electrospray operating parameters paves the way in determining the significant parameters and their design space to produce consistent alginate-RJ microbeads.
format	Conference or Workshop Item
author	Mohd Rus, Shaiqah Abu Yazid, Anis Afiful Huda Mohamad, Izzuddin Noor Ismadi, Muhammad Nur Shafiq Mohd Azlan, Nur Hakimah Rahman, Siti Radziah Doolaanea, Abd Almonem Adina, Anugerah Budipratama Haris @ Harith, Muhammad Salahuddin
author_facet	Mohd Rus, Shaiqah Abu Yazid, Anis Afiful Huda Mohamad, Izzuddin Noor Ismadi, Muhammad Nur Shafiq Mohd Azlan, Nur Hakimah Rahman, Siti Radziah Doolaanea, Abd Almonem Adina, Anugerah Budipratama Haris @ Harith, Muhammad Salahuddin
author_sort	Mohd Rus, Shaiqah
title	Screening of electrospray operating parameters in the production of alginate-royal jelly microbeads using factorial design
title_short	Screening of electrospray operating parameters in the production of alginate-royal jelly microbeads using factorial design
title_full	Screening of electrospray operating parameters in the production of alginate-royal jelly microbeads using factorial design
title_fullStr	Screening of electrospray operating parameters in the production of alginate-royal jelly microbeads using factorial design
title_full_unstemmed	Screening of electrospray operating parameters in the production of alginate-royal jelly microbeads using factorial design
title_sort	screening of electrospray operating parameters in the production of alginate-royal jelly microbeads using factorial design
publishDate	2019
url	http://irep.iium.edu.my/75505/ http://irep.iium.edu.my/75505/1/ICPRP-2019-ALL-Abstracts.pdf http://irep.iium.edu.my/75505/7/Dr%20Solah%20%20Outline.pdf http://irep.iium.edu.my/75505/8/ID%20NO.%2035_LOA%202019.pdf
first_indexed	2023-09-18T21:46:50Z
last_indexed	2023-09-18T21:46:50Z
_version_	1777413506101936128

Screening of electrospray operating parameters in the production of alginate-royal jelly microbeads using factorial design

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