Effect of different drying treatments and different extraction methods on α-glucosidase inhibitory activities of S. zalacca fruit

Effect of different drying treatments and different extraction methods on α-glucosidase inhibitory activities of S. zalacca fruit

Introduction: Salacca zalacca (Gaertn Voss), commonly known as snake fruit and belongs to the Arecaceae family and natives of Southeast Asia. This fruit is edible and have certain medicinal values. Objectives: The aim of this study was to compare the α-glucosidase inhibitory activities of different...

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Main Authors: Siddiqui, Mohammad Jamshed Ahmad, Saleh, Mohammed S M, Mat So'ad, Siti Zaiton
Format: Conference or Workshop Item
Language:English
English
English
Published: 2019
Subjects:
QD Chemistry
Online Access:http://irep.iium.edu.my/75705/
http://irep.iium.edu.my/75705/5/ID%20NO.%20176_LOA%202019.pdf
http://irep.iium.edu.my/75705/6/ICPRP2019%20programme%20book.pdf
http://irep.iium.edu.my/75705/17/Mohammed_ICPRP_176.pdf
id iium-75705
recordtype eprints
spelling iium-757052019-11-15T05:11:32Z http://irep.iium.edu.my/75705/ Effect of different drying treatments and different extraction methods on α-glucosidase inhibitory activities of S. zalacca fruit Siddiqui, Mohammad Jamshed Ahmad Saleh, Mohammed S M Mat So'ad, Siti Zaiton QD Chemistry Introduction: Salacca zalacca (Gaertn Voss), commonly known as snake fruit and belongs to the Arecaceae family and natives of Southeast Asia. This fruit is edible and have certain medicinal values. Objectives: The aim of this study was to compare the α-glucosidase inhibitory activities of different drying and extraction methods. Material and methods: Flesh of this fruit was subjected to two different drying methods namely; oven dried (OD) and freeze dried (FD) and extracts were prepared using soxhlet (SX), sonication (SC) and maceration (MC) techniques. The α-glucosidase inhibitory activity of extracts were evaluated using α-glucosidase enzyme . Results: The S. zalacca fruit extracts obtained through SC and MC demonstrated better α-glucosidase inhibitory activity as compared to SX method, specifically, the FD extracts showed higher activity compared to the OD extracts. Analysis of α-glucosidase inhibitory activity of the OD S. zalacca fruit extract indicates that extract obtained through SC method possesses significantly higher activity (IC50 79.42 µg/mL) than that of SX extracted sample which displayed IC50 at 125.73 µg/mL. Considering the effects of both methods (drying and extraction) on the α-glucosidase inhibitory activity of S. zalacca fruit extracts, extract obtained through SC of the FD fruits demonstrated the highest activity (IC50 19.40 µg/mL) Meanwhile, extracts obtained via OD and different extraction methods such as SX, MC and SC showed the least inhibition with IC50 125.73, 87.23 and 79.42 µg/mL, respectively. Conclusion: This study suggests that S. zalacca fruit has the potential for nutraceutical enhancement and as ingredient in medicinal preparation. 2019-10-19 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/75705/5/ID%20NO.%20176_LOA%202019.pdf application/pdf en http://irep.iium.edu.my/75705/6/ICPRP2019%20programme%20book.pdf application/pdf en http://irep.iium.edu.my/75705/17/Mohammed_ICPRP_176.pdf Siddiqui, Mohammad Jamshed Ahmad and Saleh, Mohammed S M and Mat So'ad, Siti Zaiton (2019) Effect of different drying treatments and different extraction methods on α-glucosidase inhibitory activities of S. zalacca fruit. In: International Conference on Pharmaceutical Research and Pharmacy Practice cum 14th IIUM-MPS Pharmacy Scientific Conference (ICPRP 2019), 19-20th October 2019, Hotel Istana Kuala Lumpur. (Unpublished)
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
English
English
topic QD Chemistry
spellingShingle QD Chemistry
Siddiqui, Mohammad Jamshed Ahmad
Saleh, Mohammed S M
Mat So'ad, Siti Zaiton
Effect of different drying treatments and different extraction methods on α-glucosidase inhibitory activities of S. zalacca fruit
description Introduction: Salacca zalacca (Gaertn Voss), commonly known as snake fruit and belongs to the Arecaceae family and natives of Southeast Asia. This fruit is edible and have certain medicinal values. Objectives: The aim of this study was to compare the α-glucosidase inhibitory activities of different drying and extraction methods. Material and methods: Flesh of this fruit was subjected to two different drying methods namely; oven dried (OD) and freeze dried (FD) and extracts were prepared using soxhlet (SX), sonication (SC) and maceration (MC) techniques. The α-glucosidase inhibitory activity of extracts were evaluated using α-glucosidase enzyme . Results: The S. zalacca fruit extracts obtained through SC and MC demonstrated better α-glucosidase inhibitory activity as compared to SX method, specifically, the FD extracts showed higher activity compared to the OD extracts. Analysis of α-glucosidase inhibitory activity of the OD S. zalacca fruit extract indicates that extract obtained through SC method possesses significantly higher activity (IC50 79.42 µg/mL) than that of SX extracted sample which displayed IC50 at 125.73 µg/mL. Considering the effects of both methods (drying and extraction) on the α-glucosidase inhibitory activity of S. zalacca fruit extracts, extract obtained through SC of the FD fruits demonstrated the highest activity (IC50 19.40 µg/mL) Meanwhile, extracts obtained via OD and different extraction methods such as SX, MC and SC showed the least inhibition with IC50 125.73, 87.23 and 79.42 µg/mL, respectively. Conclusion: This study suggests that S. zalacca fruit has the potential for nutraceutical enhancement and as ingredient in medicinal preparation.
format Conference or Workshop Item
author Siddiqui, Mohammad Jamshed Ahmad
Saleh, Mohammed S M
Mat So'ad, Siti Zaiton
author_facet Siddiqui, Mohammad Jamshed Ahmad
Saleh, Mohammed S M
Mat So'ad, Siti Zaiton
author_sort Siddiqui, Mohammad Jamshed Ahmad
title Effect of different drying treatments and different extraction methods on α-glucosidase inhibitory activities of S. zalacca fruit
title_short Effect of different drying treatments and different extraction methods on α-glucosidase inhibitory activities of S. zalacca fruit
title_full Effect of different drying treatments and different extraction methods on α-glucosidase inhibitory activities of S. zalacca fruit
title_fullStr Effect of different drying treatments and different extraction methods on α-glucosidase inhibitory activities of S. zalacca fruit
title_full_unstemmed Effect of different drying treatments and different extraction methods on α-glucosidase inhibitory activities of S. zalacca fruit
title_sort effect of different drying treatments and different extraction methods on α-glucosidase inhibitory activities of s. zalacca fruit
publishDate 2019
url http://irep.iium.edu.my/75705/
http://irep.iium.edu.my/75705/5/ID%20NO.%20176_LOA%202019.pdf
http://irep.iium.edu.my/75705/6/ICPRP2019%20programme%20book.pdf
http://irep.iium.edu.my/75705/17/Mohammed_ICPRP_176.pdf
first_indexed 2023-09-18T21:47:06Z
last_indexed 2023-09-18T21:47:06Z
_version_ 1777413522792120320

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