The effect of particle size on the physical and drug-release behaviour of chloramphenicol-loaded mini-tablets for ocular use

Ocular drug delivery is challenging because of the inherent difficulty of accessing the target sites, especially those in the posterior segment of the eye. The natural defence mechanisms, such as the constant turnover of the tear film on the surface of the eye and the blink reflex, reduce the amount...

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Main Authors:	Mohmad Sabere, Awis Sukarni, Barker, Susan A., Craig, Duncan
Format:	Conference or Workshop Item
Language:	English English
Published:	2014
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/75716/ http://irep.iium.edu.my/75716/1/Awis%20poster%20-%20Melbourne.pdf http://irep.iium.edu.my/75716/7/Certificate%20awis.pdf

id	iium-75716
recordtype	eprints
spelling	iium-757162019-11-14T07:39:09Z http://irep.iium.edu.my/75716/ The effect of particle size on the physical and drug-release behaviour of chloramphenicol-loaded mini-tablets for ocular use Mohmad Sabere, Awis Sukarni Barker, Susan A. Craig, Duncan RS Pharmacy and materia medica Ocular drug delivery is challenging because of the inherent difficulty of accessing the target sites, especially those in the posterior segment of the eye. The natural defence mechanisms, such as the constant turnover of the tear film on the surface of the eye and the blink reflex, reduce the amount of drug that is therapeutically available after surface administration. Eye drops have continued to be used as the main vehicle for ocular therapy due to their perceived patient acceptance, despite the disadvantages of fast removal and low overall drug bioavailability. Ocular mini-tablets are a potential method of improving the retention time at the site of administration and hence promoting the efficiency of drug therapy. Mini-tablets have a diameter of around 2 mm and a total weight of circa 10 mg. They can be inserted into the ocular pocket at the front of the eye, where they will hydrate and release the drug into the surface ocular fluid. Formulation and production of mini-tablets is similar to conventionally-sized tablets, but there are specific issues related to the control of the particle size distribution of the component powders that are much more significant for mini-tablets than larger tablets. 2014 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/75716/1/Awis%20poster%20-%20Melbourne.pdf application/pdf en http://irep.iium.edu.my/75716/7/Certificate%20awis.pdf Mohmad Sabere, Awis Sukarni and Barker, Susan A. and Craig, Duncan (2014) The effect of particle size on the physical and drug-release behaviour of chloramphenicol-loaded mini-tablets for ocular use. In: 5th FIP Pharmaceutical Sciences World Congress (PSWC 2014), 13th-16th Apr. 2014, Melbourne, Australia. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Mohmad Sabere, Awis Sukarni Barker, Susan A. Craig, Duncan The effect of particle size on the physical and drug-release behaviour of chloramphenicol-loaded mini-tablets for ocular use
description	Ocular drug delivery is challenging because of the inherent difficulty of accessing the target sites, especially those in the posterior segment of the eye. The natural defence mechanisms, such as the constant turnover of the tear film on the surface of the eye and the blink reflex, reduce the amount of drug that is therapeutically available after surface administration. Eye drops have continued to be used as the main vehicle for ocular therapy due to their perceived patient acceptance, despite the disadvantages of fast removal and low overall drug bioavailability. Ocular mini-tablets are a potential method of improving the retention time at the site of administration and hence promoting the efficiency of drug therapy. Mini-tablets have a diameter of around 2 mm and a total weight of circa 10 mg. They can be inserted into the ocular pocket at the front of the eye, where they will hydrate and release the drug into the surface ocular fluid. Formulation and production of mini-tablets is similar to conventionally-sized tablets, but there are specific issues related to the control of the particle size distribution of the component powders that are much more significant for mini-tablets than larger tablets.
format	Conference or Workshop Item
author	Mohmad Sabere, Awis Sukarni Barker, Susan A. Craig, Duncan
author_facet	Mohmad Sabere, Awis Sukarni Barker, Susan A. Craig, Duncan
author_sort	Mohmad Sabere, Awis Sukarni
title	The effect of particle size on the physical and drug-release behaviour of chloramphenicol-loaded mini-tablets for ocular use
title_short	The effect of particle size on the physical and drug-release behaviour of chloramphenicol-loaded mini-tablets for ocular use
title_full	The effect of particle size on the physical and drug-release behaviour of chloramphenicol-loaded mini-tablets for ocular use
title_fullStr	The effect of particle size on the physical and drug-release behaviour of chloramphenicol-loaded mini-tablets for ocular use
title_full_unstemmed	The effect of particle size on the physical and drug-release behaviour of chloramphenicol-loaded mini-tablets for ocular use
title_sort	effect of particle size on the physical and drug-release behaviour of chloramphenicol-loaded mini-tablets for ocular use
publishDate	2014
url	http://irep.iium.edu.my/75716/ http://irep.iium.edu.my/75716/1/Awis%20poster%20-%20Melbourne.pdf http://irep.iium.edu.my/75716/7/Certificate%20awis.pdf
first_indexed	2023-09-18T21:47:07Z
last_indexed	2023-09-18T21:47:07Z
_version_	1777413523785121792

The effect of particle size on the physical and drug-release behaviour of chloramphenicol-loaded mini-tablets for ocular use

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