Intra-peritoneal antibiotic utilization among Continuous Ambulatory Peritoneal Dialysis (CAPD) patients with peritonitis at a tertiary hospital setting in Malaysia

Introduction: Patients using CAPD are commonly associated with peritonitis. Peritonitis is a significant cause of morbidity, mortality and permanent transfer to haemodialysis in these patients. However, little is known about the utilization of antibiotic for the treatment of peritonitis in patients...

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Main Authors:	Ahmad, Mastura, Zin, Che Suraya, Ab Rahman, Ab Fatah
Format:	Conference or Workshop Item
Language:	English English English
Published:	2019
Subjects:	RM Therapeutics. Pharmacology
Online Access:	http://irep.iium.edu.my/76014/ http://irep.iium.edu.my/76014/1/191104_main%20page_program.pdf http://irep.iium.edu.my/76014/2/191104_mastura_poster_program.pdf http://irep.iium.edu.my/76014/3/191105_Poster%20ICPRP%202019.pdf

id	iium-76014
recordtype	eprints
spelling	iium-760142019-11-12T07:34:37Z http://irep.iium.edu.my/76014/ Intra-peritoneal antibiotic utilization among Continuous Ambulatory Peritoneal Dialysis (CAPD) patients with peritonitis at a tertiary hospital setting in Malaysia Ahmad, Mastura Zin, Che Suraya Ab Rahman, Ab Fatah RM Therapeutics. Pharmacology Introduction: Patients using CAPD are commonly associated with peritonitis. Peritonitis is a significant cause of morbidity, mortality and permanent transfer to haemodialysis in these patients. However, little is known about the utilization of antibiotic for the treatment of peritonitis in patients using CAPD. Objectives: This study aimed to evaluate the patterns of intra-peritoneal antibiotics utilization for the treatment of peritonitis in CAPD patients. Materials and Methods: This was a retrospective study conducted at a tertiary hospital setting in Malaysia. Medical records of CAPD patients who were diagnosed with peritonitis and registered with National Kidney Registry during 2013 to 2018 were reviewed. Types of antibiotics used and its dose and duration were recorded and reported using the ATC/DDD system. Results: A total of 105 peritonitis episodes were recorded from 72 patients. The most common first line empiric combinations used were ceftazidime/cefazolin (42%, n=), followed by cefepime/cefazolin (32%,n=) and ceftazidime/cloxacillin (27%, n=). For the definite therapy after obtaining the culture and sensitivity report demonstrated that vancomycin was the most prescribed (33.64%, n=), followed by meropenem (14.95%, n=) and ciprofloxacin (% , n=) . Although ciprofloxacin was the least antibiotic prescribed for CAPD-related peritonitis, the DDD/100patient-days estimates showed that its therapeutic intensity were the highest. Conclusion: There were various intraperitoneal antibiotics used for CAPD-related peritonitis and the most common empirical therapy was the combination of ceftazidine and ceftazolin while vancomycin was predominately used for definite therapy. Future studies to evaluate the clinical outcomes of the antibiotic use to have a better insight on the efficacy of the peritonitis treatment, hence better quality of patient care. 2019-10-19 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/76014/1/191104_main%20page_program.pdf application/pdf en http://irep.iium.edu.my/76014/2/191104_mastura_poster_program.pdf application/pdf en http://irep.iium.edu.my/76014/3/191105_Poster%20ICPRP%202019.pdf Ahmad, Mastura and Zin, Che Suraya and Ab Rahman, Ab Fatah (2019) Intra-peritoneal antibiotic utilization among Continuous Ambulatory Peritoneal Dialysis (CAPD) patients with peritonitis at a tertiary hospital setting in Malaysia. In: International Conference on Pharmaceutical Research and Pharmacy Practice cum 14th IIUM-MPS Pharmacy Scientific Conference (ICPRP 2019), 19-20th October 2019, Hotel Istana Kuala Lumpur. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	RM Therapeutics. Pharmacology
spellingShingle	RM Therapeutics. Pharmacology Ahmad, Mastura Zin, Che Suraya Ab Rahman, Ab Fatah Intra-peritoneal antibiotic utilization among Continuous Ambulatory Peritoneal Dialysis (CAPD) patients with peritonitis at a tertiary hospital setting in Malaysia
description	Introduction: Patients using CAPD are commonly associated with peritonitis. Peritonitis is a significant cause of morbidity, mortality and permanent transfer to haemodialysis in these patients. However, little is known about the utilization of antibiotic for the treatment of peritonitis in patients using CAPD. Objectives: This study aimed to evaluate the patterns of intra-peritoneal antibiotics utilization for the treatment of peritonitis in CAPD patients. Materials and Methods: This was a retrospective study conducted at a tertiary hospital setting in Malaysia. Medical records of CAPD patients who were diagnosed with peritonitis and registered with National Kidney Registry during 2013 to 2018 were reviewed. Types of antibiotics used and its dose and duration were recorded and reported using the ATC/DDD system. Results: A total of 105 peritonitis episodes were recorded from 72 patients. The most common first line empiric combinations used were ceftazidime/cefazolin (42%, n=), followed by cefepime/cefazolin (32%,n=) and ceftazidime/cloxacillin (27%, n=). For the definite therapy after obtaining the culture and sensitivity report demonstrated that vancomycin was the most prescribed (33.64%, n=), followed by meropenem (14.95%, n=) and ciprofloxacin (% , n=) . Although ciprofloxacin was the least antibiotic prescribed for CAPD-related peritonitis, the DDD/100patient-days estimates showed that its therapeutic intensity were the highest. Conclusion: There were various intraperitoneal antibiotics used for CAPD-related peritonitis and the most common empirical therapy was the combination of ceftazidine and ceftazolin while vancomycin was predominately used for definite therapy. Future studies to evaluate the clinical outcomes of the antibiotic use to have a better insight on the efficacy of the peritonitis treatment, hence better quality of patient care.
format	Conference or Workshop Item
author	Ahmad, Mastura Zin, Che Suraya Ab Rahman, Ab Fatah
author_facet	Ahmad, Mastura Zin, Che Suraya Ab Rahman, Ab Fatah
author_sort	Ahmad, Mastura
title	Intra-peritoneal antibiotic utilization among Continuous Ambulatory Peritoneal Dialysis (CAPD) patients with peritonitis at a tertiary hospital setting in Malaysia
title_short	Intra-peritoneal antibiotic utilization among Continuous Ambulatory Peritoneal Dialysis (CAPD) patients with peritonitis at a tertiary hospital setting in Malaysia
title_full	Intra-peritoneal antibiotic utilization among Continuous Ambulatory Peritoneal Dialysis (CAPD) patients with peritonitis at a tertiary hospital setting in Malaysia
title_fullStr	Intra-peritoneal antibiotic utilization among Continuous Ambulatory Peritoneal Dialysis (CAPD) patients with peritonitis at a tertiary hospital setting in Malaysia
title_full_unstemmed	Intra-peritoneal antibiotic utilization among Continuous Ambulatory Peritoneal Dialysis (CAPD) patients with peritonitis at a tertiary hospital setting in Malaysia
title_sort	intra-peritoneal antibiotic utilization among continuous ambulatory peritoneal dialysis (capd) patients with peritonitis at a tertiary hospital setting in malaysia
publishDate	2019
url	http://irep.iium.edu.my/76014/ http://irep.iium.edu.my/76014/1/191104_main%20page_program.pdf http://irep.iium.edu.my/76014/2/191104_mastura_poster_program.pdf http://irep.iium.edu.my/76014/3/191105_Poster%20ICPRP%202019.pdf
first_indexed	2023-09-18T21:47:30Z
last_indexed	2023-09-18T21:47:30Z
_version_	1777413547709431808

Intra-peritoneal antibiotic utilization among Continuous Ambulatory Peritoneal Dialysis (CAPD) patients with peritonitis at a tertiary hospital setting in Malaysia

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