Mnemonic and histopathological assessment of the neuroprotective effects of Murraya koenigii leaves extract in rats with partial global cerebral ischaemia

Preclinical studies have reported that Murraya koenigii leaves (MKL) could enhance memory. MKL is also known for its antioxidant activity. The current study was to assess the possible neuroprotective potential of MKL methanolic extract in a two vessel occlusion (2VO) rat model of partial global c...

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Main Authors:	Azzubaidi, Marwan Saad, Al-Ani, Imad Matloub Dally
Format:	Article
Language:	English English English
Published:	Kulliyyah of Medicine, International Islamic University Malaysia 2019
Subjects:	R Medicine (General) RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/76245/ http://irep.iium.edu.my/76245/ http://irep.iium.edu.my/76245/1/76245_Mnemonic%20and%20histopathological%20assessment.pdf http://irep.iium.edu.my/76245/2/76245_Mnemonic%20and%20histopathological%20assessment_SCOPUS.pdf http://irep.iium.edu.my/76245/3/76245_Mnemonic%20and%20histopathological%20assessment_WOS.pdf

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spelling	iium-762452019-12-17T01:44:37Z http://irep.iium.edu.my/76245/ Mnemonic and histopathological assessment of the neuroprotective effects of Murraya koenigii leaves extract in rats with partial global cerebral ischaemia Azzubaidi, Marwan Saad Al-Ani, Imad Matloub Dally R Medicine (General) RS Pharmacy and materia medica Preclinical studies have reported that Murraya koenigii leaves (MKL) could enhance memory. MKL is also known for its antioxidant activity. The current study was to assess the possible neuroprotective potential of MKL methanolic extract in a two vessel occlusion (2VO) rat model of partial global cerebral ischaemia. Methods: Rats were divided into memory and learning groups. Each group was subdivided into sham control, untreated 2VO and MKL-treated 2VO subgroups. The Morris water maze test was implemented to assess the rats’ cognitive function postoperatively. Brain samples were histopathologically examined for viable neurons within the CA1 hippocampal region. Results: Water maze test findings showed that MKL positively improved memory and learning impairments. However, this improvement in memory test for the treated group was still significantly inferior to that of the healthy control group. Additionally, MKL treated group exhibited insignificant difference in the number of viable hippocampal CA1 pyramidal neurons from that of the untreated 2VO group, whereas both MKL treated and untreated 2VO groups showed significantly less viable neurons when compared with the control group. Conclusion: MKL extract modestly improved memory without providing substantial neuroprotective action to the hippocampal neurons in rats with chronic partial global cerebral ischaemia. Kulliyyah of Medicine, International Islamic University Malaysia 2019-08-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/76245/1/76245_Mnemonic%20and%20histopathological%20assessment.pdf application/pdf en http://irep.iium.edu.my/76245/2/76245_Mnemonic%20and%20histopathological%20assessment_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/76245/3/76245_Mnemonic%20and%20histopathological%20assessment_WOS.pdf Azzubaidi, Marwan Saad and Al-Ani, Imad Matloub Dally (2019) Mnemonic and histopathological assessment of the neuroprotective effects of Murraya koenigii leaves extract in rats with partial global cerebral ischaemia. International Medical Journal Malaysia (IMJM), 18 (2). pp. 77-86. ISSN 1823-4631 https://journals.iium.edu.my/kom/index.php/imjm/article/view/93
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	R Medicine (General) RS Pharmacy and materia medica
spellingShingle	R Medicine (General) RS Pharmacy and materia medica Azzubaidi, Marwan Saad Al-Ani, Imad Matloub Dally Mnemonic and histopathological assessment of the neuroprotective effects of Murraya koenigii leaves extract in rats with partial global cerebral ischaemia
description	Preclinical studies have reported that Murraya koenigii leaves (MKL) could enhance memory. MKL is also known for its antioxidant activity. The current study was to assess the possible neuroprotective potential of MKL methanolic extract in a two vessel occlusion (2VO) rat model of partial global cerebral ischaemia. Methods: Rats were divided into memory and learning groups. Each group was subdivided into sham control, untreated 2VO and MKL-treated 2VO subgroups. The Morris water maze test was implemented to assess the rats’ cognitive function postoperatively. Brain samples were histopathologically examined for viable neurons within the CA1 hippocampal region. Results: Water maze test findings showed that MKL positively improved memory and learning impairments. However, this improvement in memory test for the treated group was still significantly inferior to that of the healthy control group. Additionally, MKL treated group exhibited insignificant difference in the number of viable hippocampal CA1 pyramidal neurons from that of the untreated 2VO group, whereas both MKL treated and untreated 2VO groups showed significantly less viable neurons when compared with the control group. Conclusion: MKL extract modestly improved memory without providing substantial neuroprotective action to the hippocampal neurons in rats with chronic partial global cerebral ischaemia.
format	Article
author	Azzubaidi, Marwan Saad Al-Ani, Imad Matloub Dally
author_facet	Azzubaidi, Marwan Saad Al-Ani, Imad Matloub Dally
author_sort	Azzubaidi, Marwan Saad
title	Mnemonic and histopathological assessment of the neuroprotective effects of Murraya koenigii leaves extract in rats with partial global cerebral ischaemia
title_short	Mnemonic and histopathological assessment of the neuroprotective effects of Murraya koenigii leaves extract in rats with partial global cerebral ischaemia
title_full	Mnemonic and histopathological assessment of the neuroprotective effects of Murraya koenigii leaves extract in rats with partial global cerebral ischaemia
title_fullStr	Mnemonic and histopathological assessment of the neuroprotective effects of Murraya koenigii leaves extract in rats with partial global cerebral ischaemia
title_full_unstemmed	Mnemonic and histopathological assessment of the neuroprotective effects of Murraya koenigii leaves extract in rats with partial global cerebral ischaemia
title_sort	mnemonic and histopathological assessment of the neuroprotective effects of murraya koenigii leaves extract in rats with partial global cerebral ischaemia
publisher	Kulliyyah of Medicine, International Islamic University Malaysia
publishDate	2019
url	http://irep.iium.edu.my/76245/ http://irep.iium.edu.my/76245/ http://irep.iium.edu.my/76245/1/76245_Mnemonic%20and%20histopathological%20assessment.pdf http://irep.iium.edu.my/76245/2/76245_Mnemonic%20and%20histopathological%20assessment_SCOPUS.pdf http://irep.iium.edu.my/76245/3/76245_Mnemonic%20and%20histopathological%20assessment_WOS.pdf
first_indexed	2023-09-18T21:47:46Z
last_indexed	2023-09-18T21:47:46Z
_version_	1777413565026664448

Mnemonic and histopathological assessment of the neuroprotective effects of Murraya koenigii leaves extract in rats with partial global cerebral ischaemia

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