Cerebral small vessel disease (CSVD) – lessons from the animal models

Cerebral small vessel disease (CSVD) refers to a spectrum of clinical and imaging findings resulting from pathological processes of various etiologies affecting cerebral arterioles, perforating arteries, capillaries, and venules. Unlike large vessels, it is a challenge to visualize small vessels in...

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Main Authors:	Mustapha, Muzaimi, Che Mohd Nassir, Che Mohd Nasril, Aminuddin, Niferiti, Ahmad Safri, Amanina, Mohamad Ghazali, Mazira
Format:	Article
Language:	English English
Published:	Frontiers Media S.A. 2019
Subjects:	QP Physiology
Online Access:	http://irep.iium.edu.my/76306/ http://irep.iium.edu.my/76306/ http://irep.iium.edu.my/76306/ http://irep.iium.edu.my/76306/1/CSVD_lessons%20from%20animal%20models.pdf http://irep.iium.edu.my/76306/7/fphys-10-01317.pdf

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spelling	iium-763062020-02-28T08:28:09Z http://irep.iium.edu.my/76306/ Cerebral small vessel disease (CSVD) – lessons from the animal models Mustapha, Muzaimi Che Mohd Nassir, Che Mohd Nasril Aminuddin, Niferiti Ahmad Safri, Amanina Mohamad Ghazali, Mazira QP Physiology Cerebral small vessel disease (CSVD) refers to a spectrum of clinical and imaging findings resulting from pathological processes of various etiologies affecting cerebral arterioles, perforating arteries, capillaries, and venules. Unlike large vessels, it is a challenge to visualize small vessels in vivo, hence the difficulty to directly monitor the natural progression of the disease. CSVD might progress for many years during the early stage of the disease as it remains asymptomatic. Prevalent among elderly individuals, CSVD has been alarmingly reported as an important precursor of full-blown stroke and vascular dementia. Growing evidence has also shown a significant association between CSVD’s radiological manifestation with dementia and Alzheimer’s disease (AD) pathology. Although it remains contentious as to whether CSVD is a cause or sequelae of AD, it is not far-fetched to posit that effective therapeutic measures of CSVD would mitigate the overall burden of dementia. Nevertheless, the unifying theory on the pathomechanism of the disease remains elusive, hence the lack of effective therapeutic approaches. Thus, this chapter consolidates the contemporary insights from numerous experimental animal models of CSVD, to date: from the available experimental animal models of CSVD and its translational research value; the pathomechanical aspects of the disease; relevant aspects on systems biology; opportunities for early disease biomarkers; and finally, converging approaches for future therapeutic directions of CSVD. Frontiers Media S.A. 2019-10-24 Article PeerReviewed application/pdf en http://irep.iium.edu.my/76306/1/CSVD_lessons%20from%20animal%20models.pdf application/pdf en http://irep.iium.edu.my/76306/7/fphys-10-01317.pdf Mustapha, Muzaimi and Che Mohd Nassir, Che Mohd Nasril and Aminuddin, Niferiti and Ahmad Safri, Amanina and Mohamad Ghazali, Mazira (2019) Cerebral small vessel disease (CSVD) – lessons from the animal models. Frontiers in Physiology, 10. pp. 1-29. ISSN 1664042X https://www.frontiersin.org/articles/10.3389/fphys.2019.01317/full 10.3389/fphys.2019.01317
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QP Physiology
spellingShingle	QP Physiology Mustapha, Muzaimi Che Mohd Nassir, Che Mohd Nasril Aminuddin, Niferiti Ahmad Safri, Amanina Mohamad Ghazali, Mazira Cerebral small vessel disease (CSVD) – lessons from the animal models
description	Cerebral small vessel disease (CSVD) refers to a spectrum of clinical and imaging findings resulting from pathological processes of various etiologies affecting cerebral arterioles, perforating arteries, capillaries, and venules. Unlike large vessels, it is a challenge to visualize small vessels in vivo, hence the difficulty to directly monitor the natural progression of the disease. CSVD might progress for many years during the early stage of the disease as it remains asymptomatic. Prevalent among elderly individuals, CSVD has been alarmingly reported as an important precursor of full-blown stroke and vascular dementia. Growing evidence has also shown a significant association between CSVD’s radiological manifestation with dementia and Alzheimer’s disease (AD) pathology. Although it remains contentious as to whether CSVD is a cause or sequelae of AD, it is not far-fetched to posit that effective therapeutic measures of CSVD would mitigate the overall burden of dementia. Nevertheless, the unifying theory on the pathomechanism of the disease remains elusive, hence the lack of effective therapeutic approaches. Thus, this chapter consolidates the contemporary insights from numerous experimental animal models of CSVD, to date: from the available experimental animal models of CSVD and its translational research value; the pathomechanical aspects of the disease; relevant aspects on systems biology; opportunities for early disease biomarkers; and finally, converging approaches for future therapeutic directions of CSVD.
format	Article
author	Mustapha, Muzaimi Che Mohd Nassir, Che Mohd Nasril Aminuddin, Niferiti Ahmad Safri, Amanina Mohamad Ghazali, Mazira
author_facet	Mustapha, Muzaimi Che Mohd Nassir, Che Mohd Nasril Aminuddin, Niferiti Ahmad Safri, Amanina Mohamad Ghazali, Mazira
author_sort	Mustapha, Muzaimi
title	Cerebral small vessel disease (CSVD) – lessons from the animal models
title_short	Cerebral small vessel disease (CSVD) – lessons from the animal models
title_full	Cerebral small vessel disease (CSVD) – lessons from the animal models
title_fullStr	Cerebral small vessel disease (CSVD) – lessons from the animal models
title_full_unstemmed	Cerebral small vessel disease (CSVD) – lessons from the animal models
title_sort	cerebral small vessel disease (csvd) – lessons from the animal models
publisher	Frontiers Media S.A.
publishDate	2019
url	http://irep.iium.edu.my/76306/ http://irep.iium.edu.my/76306/ http://irep.iium.edu.my/76306/ http://irep.iium.edu.my/76306/1/CSVD_lessons%20from%20animal%20models.pdf http://irep.iium.edu.my/76306/7/fphys-10-01317.pdf
first_indexed	2023-09-18T21:47:51Z
last_indexed	2023-09-18T21:47:51Z
_version_	1777413570534834176

Cerebral small vessel disease (CSVD) – lessons from the animal models

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