Neuroleptic malignant syndrome in a patient with bipolar depression on stable dose of quetiapine
We report a case of a 37-year-old widow with a diagnosis of bipolar I disorder who presented with catatonia and neuroleptic malignant syndrome (NMS) while in the depressive phase of her illness. The neuroleptic malignant syndrome developed in the context of a stable dose of long-acting quetiapine (3...
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Ministry of Health Brunei Darussalam
2016
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iium-770572020-02-14T01:07:25Z http://irep.iium.edu.my/77057/ Neuroleptic malignant syndrome in a patient with bipolar depression on stable dose of quetiapine Zakaria, Rozanizam Husain, Maruzairi Chin, Lie Joo R Medicine (General) We report a case of a 37-year-old widow with a diagnosis of bipolar I disorder who presented with catatonia and neuroleptic malignant syndrome (NMS) while in the depressive phase of her illness. The neuroleptic malignant syndrome developed in the context of a stable dose of long-acting quetiapine (300mg) for five years. Her depression and catatonic state were hypothesised as the contributing factors for her NMS. Her catatonic symptoms were initially managed with regular benzodiazepines and she was later given electroconvulsive therapy during her admission. Her NMS improved after five days and her catatonic symptoms fully resolved after the second electroconvulsive therapy. The aim of this case report is to highlight the presentation of NMS in a depressed and catatonic patient, despite her long-term stability and a relatively low dose of quetiapine. Ministry of Health Brunei Darussalam 2016-08 Article PeerReviewed application/pdf en http://irep.iium.edu.my/77057/1/BIMJ2016-CR045revisedforpublication%20%281%29.docx application/pdf en http://irep.iium.edu.my/77057/3/bimj2016124151.pdf Zakaria, Rozanizam and Husain, Maruzairi and Chin, Lie Joo (2016) Neuroleptic malignant syndrome in a patient with bipolar depression on stable dose of quetiapine. Brunei International Medical Journal, 12 (4). pp. 151-154. ISSN 1560-5876 E-ISSN 2079-3146 http://www.bimjonline.com/PDF/Bimj%202016%20Volume%2012,%20Issue%204/bimj2016124151.pdf |
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R Medicine (General) Zakaria, Rozanizam Husain, Maruzairi Chin, Lie Joo Neuroleptic malignant syndrome in a patient with bipolar depression on stable dose of quetiapine |
description |
We report a case of a 37-year-old widow with a diagnosis of bipolar I disorder who presented with catatonia and neuroleptic malignant syndrome (NMS) while in the depressive phase of her illness. The neuroleptic malignant syndrome developed in the context of a stable dose of long-acting quetiapine (300mg) for five years. Her depression and catatonic state were hypothesised as the contributing factors for her NMS. Her catatonic symptoms were initially managed with regular benzodiazepines and she was later given electroconvulsive therapy during her admission. Her NMS improved after five days and her catatonic symptoms fully resolved after the second electroconvulsive therapy. The aim of this case report is to highlight the presentation of NMS in a depressed and catatonic patient, despite her long-term stability and a relatively low dose of quetiapine. |
format |
Article |
author |
Zakaria, Rozanizam Husain, Maruzairi Chin, Lie Joo |
author_facet |
Zakaria, Rozanizam Husain, Maruzairi Chin, Lie Joo |
author_sort |
Zakaria, Rozanizam |
title |
Neuroleptic malignant syndrome in a patient with bipolar depression on stable dose of quetiapine |
title_short |
Neuroleptic malignant syndrome in a patient with bipolar depression on stable dose of quetiapine |
title_full |
Neuroleptic malignant syndrome in a patient with bipolar depression on stable dose of quetiapine |
title_fullStr |
Neuroleptic malignant syndrome in a patient with bipolar depression on stable dose of quetiapine |
title_full_unstemmed |
Neuroleptic malignant syndrome in a patient with bipolar depression on stable dose of quetiapine |
title_sort |
neuroleptic malignant syndrome in a patient with bipolar depression on stable dose of quetiapine |
publisher |
Ministry of Health Brunei Darussalam |
publishDate |
2016 |
url |
http://irep.iium.edu.my/77057/ http://irep.iium.edu.my/77057/ http://irep.iium.edu.my/77057/1/BIMJ2016-CR045revisedforpublication%20%281%29.docx http://irep.iium.edu.my/77057/3/bimj2016124151.pdf |
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2023-09-18T21:48:46Z |
last_indexed |
2023-09-18T21:48:46Z |
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1777413627916058624 |