The effect of tualang honey in chronic exposure of high cholesterol diet in animal model

Introduction: Hyperlipidaemia accompanies chronic renal disease either as a consequence of the renal dysfunction or as part of generalized metabolic derangements. The aim of this study was to determine the effects of tualang honey (TH) on the kidneys of animal model with chronic exposure to high cho...

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Main Authors:	Abdul Rahim, Roslina, Muhammad, Naznin, Abdul Ghani, Azril Shahreez, Abdullah, Nor Zamzila, A.Talib, Norlelawati, Harun, Norra
Format:	Conference or Workshop Item
Language:	English English
Published:	2019
Subjects:	QP Physiology R Medicine (General) RB Pathology RM Therapeutics. Pharmacology RM214 Diet therapy. Diet and dietectics in disease RZ Other systems of medicine
Online Access:	http://irep.iium.edu.my/77186/ http://irep.iium.edu.my/77186/1/MRS2019%20.png http://irep.iium.edu.my/77186/2/MRS%202019%20Abstract%20Book.pdf

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spelling	iium-771862020-01-02T08:47:47Z http://irep.iium.edu.my/77186/ The effect of tualang honey in chronic exposure of high cholesterol diet in animal model Abdul Rahim, Roslina Muhammad, Naznin Abdul Ghani, Azril Shahreez Abdullah, Nor Zamzila A.Talib, Norlelawati Harun, Norra QP Physiology R Medicine (General) RB Pathology RM Therapeutics. Pharmacology RM214 Diet therapy. Diet and dietectics in disease RZ Other systems of medicine Introduction: Hyperlipidaemia accompanies chronic renal disease either as a consequence of the renal dysfunction or as part of generalized metabolic derangements. The aim of this study was to determine the effects of tualang honey (TH) on the kidneys of animal model with chronic exposure to high cholesterol diet. Materials and method: Twenty Sprague-Dawley rats were divided into two groups, the high cholesterol diet (12% CD (n= 16) and standard diet (SD) (n=4) and were fed for 12 weeks. After 12 weeks, the rats in the 12% CD group were subsequently divided into four groups. The first group was continued with only 12% CD while the other 3 groups in addition to the 12% CD, they were given TH treatment at different concentrations (1.2, 2.4 and 3.0 g/kg/day) for 4 weeks. Biochemical analysis of lipid profile and renal function were performed at the end of the experiment. The animals were sacrificed and the kidneys were harvested for histological examination. Results: In the 12 weeks HCD group, the serum cholesterol, LDL-c and creatinine levels were significantly higher) compared to that of the SD group. All groups with the tualang honey treatment had significant reduction in the LDL-c, triglyceride and creatinine levels. Histological examination of the kidney tissues of the HCD and HCD+TH groups at 16 weeks revealed segmental mesangial proliferation of some glomeruli with focal mesangial matrix expansion. No areas of periglomerular and peritubular fibrosis were observed. Conclusion: Tualang honey supplementation of animal model with chronic exposure to high cholesterol diet improved the renal function hence suggesting the its renoprotective effect. However, there were no changes seen in the histology of the kidneys . Additionally, tualang honey showed improvement in the LDL-c and triglyceride levels indicating its lipid lowering activities. 2019-10-09 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/77186/1/MRS2019%20.png application/pdf en http://irep.iium.edu.my/77186/2/MRS%202019%20Abstract%20Book.pdf Abdul Rahim, Roslina and Muhammad, Naznin and Abdul Ghani, Azril Shahreez and Abdullah, Nor Zamzila and A.Talib, Norlelawati and Harun, Norra (2019) The effect of tualang honey in chronic exposure of high cholesterol diet in animal model. In: 5th Medical Research Symposium, 9th October 2019, Kuantan, Pahang. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QP Physiology R Medicine (General) RB Pathology RM Therapeutics. Pharmacology RM214 Diet therapy. Diet and dietectics in disease RZ Other systems of medicine
spellingShingle	QP Physiology R Medicine (General) RB Pathology RM Therapeutics. Pharmacology RM214 Diet therapy. Diet and dietectics in disease RZ Other systems of medicine Abdul Rahim, Roslina Muhammad, Naznin Abdul Ghani, Azril Shahreez Abdullah, Nor Zamzila A.Talib, Norlelawati Harun, Norra The effect of tualang honey in chronic exposure of high cholesterol diet in animal model
description	Introduction: Hyperlipidaemia accompanies chronic renal disease either as a consequence of the renal dysfunction or as part of generalized metabolic derangements. The aim of this study was to determine the effects of tualang honey (TH) on the kidneys of animal model with chronic exposure to high cholesterol diet. Materials and method: Twenty Sprague-Dawley rats were divided into two groups, the high cholesterol diet (12% CD (n= 16) and standard diet (SD) (n=4) and were fed for 12 weeks. After 12 weeks, the rats in the 12% CD group were subsequently divided into four groups. The first group was continued with only 12% CD while the other 3 groups in addition to the 12% CD, they were given TH treatment at different concentrations (1.2, 2.4 and 3.0 g/kg/day) for 4 weeks. Biochemical analysis of lipid profile and renal function were performed at the end of the experiment. The animals were sacrificed and the kidneys were harvested for histological examination. Results: In the 12 weeks HCD group, the serum cholesterol, LDL-c and creatinine levels were significantly higher) compared to that of the SD group. All groups with the tualang honey treatment had significant reduction in the LDL-c, triglyceride and creatinine levels. Histological examination of the kidney tissues of the HCD and HCD+TH groups at 16 weeks revealed segmental mesangial proliferation of some glomeruli with focal mesangial matrix expansion. No areas of periglomerular and peritubular fibrosis were observed. Conclusion: Tualang honey supplementation of animal model with chronic exposure to high cholesterol diet improved the renal function hence suggesting the its renoprotective effect. However, there were no changes seen in the histology of the kidneys . Additionally, tualang honey showed improvement in the LDL-c and triglyceride levels indicating its lipid lowering activities.
format	Conference or Workshop Item
author	Abdul Rahim, Roslina Muhammad, Naznin Abdul Ghani, Azril Shahreez Abdullah, Nor Zamzila A.Talib, Norlelawati Harun, Norra
author_facet	Abdul Rahim, Roslina Muhammad, Naznin Abdul Ghani, Azril Shahreez Abdullah, Nor Zamzila A.Talib, Norlelawati Harun, Norra
author_sort	Abdul Rahim, Roslina
title	The effect of tualang honey in chronic exposure of high cholesterol diet in animal model
title_short	The effect of tualang honey in chronic exposure of high cholesterol diet in animal model
title_full	The effect of tualang honey in chronic exposure of high cholesterol diet in animal model
title_fullStr	The effect of tualang honey in chronic exposure of high cholesterol diet in animal model
title_full_unstemmed	The effect of tualang honey in chronic exposure of high cholesterol diet in animal model
title_sort	effect of tualang honey in chronic exposure of high cholesterol diet in animal model
publishDate	2019
url	http://irep.iium.edu.my/77186/ http://irep.iium.edu.my/77186/1/MRS2019%20.png http://irep.iium.edu.my/77186/2/MRS%202019%20Abstract%20Book.pdf
first_indexed	2023-09-18T21:48:54Z
last_indexed	2023-09-18T21:48:54Z
_version_	1777413636660133888

The effect of tualang honey in chronic exposure of high cholesterol diet in animal model

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