Effects of agarwood at multiple stages of carcinogenesis: a systematic review

This systematic review sought to determine whether preclinical biological and mechanistic evidences of agarwood materials reported at multiple carcinogenic stages are significant to support plausibility of agarwood materials as potential therapeutics for cancer. Agarwood materials have been repor...

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Main Authors:	Hashim, Yumi Zuhanis Has-Yun, Samsudin, Nurhusna, Ab Ilah, Nazurah, Mohammad Tormizi, Ummu Athiyah, Mohd Nasir, Asmak Muti'ah, Zainudin, Nur Umisha
Format:	Conference or Workshop Item
Language:	English
Published:	2019
Subjects:	RM Therapeutics. Pharmacology
Online Access:	http://irep.iium.edu.my/77208/ http://irep.iium.edu.my/77208/7/77208%20abstract.pdf

id	iium-77208
recordtype	eprints
spelling	iium-772082020-01-24T01:37:07Z http://irep.iium.edu.my/77208/ Effects of agarwood at multiple stages of carcinogenesis: a systematic review Hashim, Yumi Zuhanis Has-Yun Samsudin, Nurhusna Ab Ilah, Nazurah Mohammad Tormizi, Ummu Athiyah Mohd Nasir, Asmak Muti'ah Zainudin, Nur Umisha RM Therapeutics. Pharmacology This systematic review sought to determine whether preclinical biological and mechanistic evidences of agarwood materials reported at multiple carcinogenic stages are significant to support plausibility of agarwood materials as potential therapeutics for cancer. Agarwood materials have been reported to have pre-clinical (in vitro and in vivo) evidences of anti-cancer effects in various types of cancer, however the diverse range of types of agarwood species and materials as well as carcinogenesis stage pose a challenge to discern the potential candidate or scheme for further work. More recent reports on agarwood toxicity further complicates the search for the potential therapeutics. Study selection criteria was determined based on framework outlined by the World Cancer Research Fund (WCRF) International/University of Bristol (UoB). In addition, care was taken to follow PRISMA reporting guidelines as closely as possible. Anti-cancer effect in the studies must be related to properties of antigenotoxic, apoptosis, antioxidant, cytotoxic, anti-inflammatory, anti- attachment, anti-spreading, anti-metastatic and anti-angiogenic. Papers that are published other than in English; review paper, comments and opinions; short paper (less than 6 pages), poster keynote and abstract; and papers published in 1900 and below are excluded. Search strategy was applied to selected electronic databases including Scopus, Springerlink, Taylor & Francis Online, Cambridge Core, Pub MEDLINE, Oxford Academic, Science Direct and Wiley Online Library. Number of 4473 studies were initially identified and 860 studies were included following screening. After removing duplicates, 112 papers were further analysed for eligibility. Presently, 47 studies judged eligible. Interim findings showed several characteristic trends where type of materials studied ranges from leaf, branch and essential oil; species studied are region/country specific but types of cancer studied are not research group-specific. Initial conclusion from the preclinical studies could be made where different species and types of agarwood material may have effects at multiple carcinogenesis stage in various types of cancer. 2019 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/77208/7/77208%20abstract.pdf Hashim, Yumi Zuhanis Has-Yun and Samsudin, Nurhusna and Ab Ilah, Nazurah and Mohammad Tormizi, Ummu Athiyah and Mohd Nasir, Asmak Muti'ah and Zainudin, Nur Umisha (2019) Effects of agarwood at multiple stages of carcinogenesis: a systematic review. In: 1st International Symposium of Agarwood and Aromatic Plants 2019 (1st ISAAP 2019), 1st-2nd October 2019, Lombok, Indonesia. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RM Therapeutics. Pharmacology
spellingShingle	RM Therapeutics. Pharmacology Hashim, Yumi Zuhanis Has-Yun Samsudin, Nurhusna Ab Ilah, Nazurah Mohammad Tormizi, Ummu Athiyah Mohd Nasir, Asmak Muti'ah Zainudin, Nur Umisha Effects of agarwood at multiple stages of carcinogenesis: a systematic review
description	This systematic review sought to determine whether preclinical biological and mechanistic evidences of agarwood materials reported at multiple carcinogenic stages are significant to support plausibility of agarwood materials as potential therapeutics for cancer. Agarwood materials have been reported to have pre-clinical (in vitro and in vivo) evidences of anti-cancer effects in various types of cancer, however the diverse range of types of agarwood species and materials as well as carcinogenesis stage pose a challenge to discern the potential candidate or scheme for further work. More recent reports on agarwood toxicity further complicates the search for the potential therapeutics. Study selection criteria was determined based on framework outlined by the World Cancer Research Fund (WCRF) International/University of Bristol (UoB). In addition, care was taken to follow PRISMA reporting guidelines as closely as possible. Anti-cancer effect in the studies must be related to properties of antigenotoxic, apoptosis, antioxidant, cytotoxic, anti-inflammatory, anti- attachment, anti-spreading, anti-metastatic and anti-angiogenic. Papers that are published other than in English; review paper, comments and opinions; short paper (less than 6 pages), poster keynote and abstract; and papers published in 1900 and below are excluded. Search strategy was applied to selected electronic databases including Scopus, Springerlink, Taylor & Francis Online, Cambridge Core, Pub MEDLINE, Oxford Academic, Science Direct and Wiley Online Library. Number of 4473 studies were initially identified and 860 studies were included following screening. After removing duplicates, 112 papers were further analysed for eligibility. Presently, 47 studies judged eligible. Interim findings showed several characteristic trends where type of materials studied ranges from leaf, branch and essential oil; species studied are region/country specific but types of cancer studied are not research group-specific. Initial conclusion from the preclinical studies could be made where different species and types of agarwood material may have effects at multiple carcinogenesis stage in various types of cancer.
format	Conference or Workshop Item
author	Hashim, Yumi Zuhanis Has-Yun Samsudin, Nurhusna Ab Ilah, Nazurah Mohammad Tormizi, Ummu Athiyah Mohd Nasir, Asmak Muti'ah Zainudin, Nur Umisha
author_facet	Hashim, Yumi Zuhanis Has-Yun Samsudin, Nurhusna Ab Ilah, Nazurah Mohammad Tormizi, Ummu Athiyah Mohd Nasir, Asmak Muti'ah Zainudin, Nur Umisha
author_sort	Hashim, Yumi Zuhanis Has-Yun
title	Effects of agarwood at multiple stages of carcinogenesis: a systematic review
title_short	Effects of agarwood at multiple stages of carcinogenesis: a systematic review
title_full	Effects of agarwood at multiple stages of carcinogenesis: a systematic review
title_fullStr	Effects of agarwood at multiple stages of carcinogenesis: a systematic review
title_full_unstemmed	Effects of agarwood at multiple stages of carcinogenesis: a systematic review
title_sort	effects of agarwood at multiple stages of carcinogenesis: a systematic review
publishDate	2019
url	http://irep.iium.edu.my/77208/ http://irep.iium.edu.my/77208/7/77208%20abstract.pdf
first_indexed	2023-09-18T21:48:55Z
last_indexed	2023-09-18T21:48:55Z
_version_	1777413637565054976

Effects of agarwood at multiple stages of carcinogenesis: a systematic review

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