Synthesis and SAR studies of new chromone derivatives as Inhibitors of PGE2 production

Prostaglandin E2 (PGE2) is an essential metabolite of the cyclooxygenase pathway in the human body. However, excessive production of PGE2 has been implicated with a variety of inflammatory and cancer diseases. Studies have revealed that blockade of PGE2 production could enhance the innate immune fun...

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Main Authors:	Rullah, Kamal, Mohd Aluwi, Mohd Fadhlizil Fasihi, Kok Wai, Lam
Format:	Conference or Workshop Item
Language:	English English English English
Published:	2019
Subjects:	RS403 Materia Medica-Pharmaceutical Chemistry
Online Access:	http://irep.iium.edu.my/77275/ http://irep.iium.edu.my/77275/1/Abstract.pdf http://irep.iium.edu.my/77275/2/1st-MSC-3-4-Dec-2019-third-announcement.jpg http://irep.iium.edu.my/77275/3/Abstract%20Acceptance%20Letter.pdf http://irep.iium.edu.my/77275/4/Presentation_MACR.pdf

id	iium-77275
recordtype	eprints
spelling	iium-772752019-12-19T07:01:12Z http://irep.iium.edu.my/77275/ Synthesis and SAR studies of new chromone derivatives as Inhibitors of PGE2 production Rullah, Kamal Mohd Aluwi, Mohd Fadhlizil Fasihi Kok Wai, Lam RS403 Materia Medica-Pharmaceutical Chemistry Prostaglandin E2 (PGE2) is an essential metabolite of the cyclooxygenase pathway in the human body. However, excessive production of PGE2 has been implicated with a variety of inflammatory and cancer diseases. Studies have revealed that blockade of PGE2 production could enhance the innate immune function both in vitro and ex vivo experiments. Hence, this could serve as a useful strategy for preventing and treating inflammation and cancer in related individuals. Natural products have been of great interest for many years, and have provided modern medicine with numerous useful drug leads. One of the families of natural products that has been widely explored for their biological activities is the chromones. 2019-12-03 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/77275/1/Abstract.pdf application/pdf en http://irep.iium.edu.my/77275/2/1st-MSC-3-4-Dec-2019-third-announcement.jpg application/pdf en http://irep.iium.edu.my/77275/3/Abstract%20Acceptance%20Letter.pdf application/pdf en http://irep.iium.edu.my/77275/4/Presentation_MACR.pdf Rullah, Kamal and Mohd Aluwi, Mohd Fadhlizil Fasihi and Kok Wai, Lam (2019) Synthesis and SAR studies of new chromone derivatives as Inhibitors of PGE2 production. In: 1st Malaysian Association for Cancer Research (MACR) Scientific Conference (1st MSC) 2019, 3th-4th December 2019, MAHSA University, Bandar Saujana Putra, Selangor. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English English
topic	RS403 Materia Medica-Pharmaceutical Chemistry
spellingShingle	RS403 Materia Medica-Pharmaceutical Chemistry Rullah, Kamal Mohd Aluwi, Mohd Fadhlizil Fasihi Kok Wai, Lam Synthesis and SAR studies of new chromone derivatives as Inhibitors of PGE2 production
description	Prostaglandin E2 (PGE2) is an essential metabolite of the cyclooxygenase pathway in the human body. However, excessive production of PGE2 has been implicated with a variety of inflammatory and cancer diseases. Studies have revealed that blockade of PGE2 production could enhance the innate immune function both in vitro and ex vivo experiments. Hence, this could serve as a useful strategy for preventing and treating inflammation and cancer in related individuals. Natural products have been of great interest for many years, and have provided modern medicine with numerous useful drug leads. One of the families of natural products that has been widely explored for their biological activities is the chromones.
format	Conference or Workshop Item
author	Rullah, Kamal Mohd Aluwi, Mohd Fadhlizil Fasihi Kok Wai, Lam
author_facet	Rullah, Kamal Mohd Aluwi, Mohd Fadhlizil Fasihi Kok Wai, Lam
author_sort	Rullah, Kamal
title	Synthesis and SAR studies of new chromone derivatives as Inhibitors of PGE2 production
title_short	Synthesis and SAR studies of new chromone derivatives as Inhibitors of PGE2 production
title_full	Synthesis and SAR studies of new chromone derivatives as Inhibitors of PGE2 production
title_fullStr	Synthesis and SAR studies of new chromone derivatives as Inhibitors of PGE2 production
title_full_unstemmed	Synthesis and SAR studies of new chromone derivatives as Inhibitors of PGE2 production
title_sort	synthesis and sar studies of new chromone derivatives as inhibitors of pge2 production
publishDate	2019
url	http://irep.iium.edu.my/77275/ http://irep.iium.edu.my/77275/1/Abstract.pdf http://irep.iium.edu.my/77275/2/1st-MSC-3-4-Dec-2019-third-announcement.jpg http://irep.iium.edu.my/77275/3/Abstract%20Acceptance%20Letter.pdf http://irep.iium.edu.my/77275/4/Presentation_MACR.pdf
first_indexed	2023-09-18T21:49:00Z
last_indexed	2023-09-18T21:49:00Z
_version_	1777413642703077376

Synthesis and SAR studies of new chromone derivatives as Inhibitors of PGE2 production

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