Effect of curcumin dose, treatment duration and intervention type on tumor inhibition in animal models: a systematic literature review using meta-analysis techniques

Curcuma longa L. uses widely as a traditional medicine especially in India and China for the treatment of diabetic wounds, inflammatory, hepatic, and digestive disorders. These effects lead to the research of this plant for the treatment of chronic diseases. To assess the...

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Main Authors:	Nasruddin, Arina, Amid, Azura
Format:	Article
Language:	English
Published:	IIUM Press 2019
Subjects:	TP248.13 Biotechnology
Online Access:	http://irep.iium.edu.my/77562/ http://irep.iium.edu.my/77562/ http://irep.iium.edu.my/77562/1/View%20of%20Effect%20of%20Curcumin%20Dose%2C%20Treatment%20Duration%20and%20Intervention%20Type%20on%20Tumor%20Inhibition%20in%20Animal%20Models_%20A%20Systematic%20Review%20and%20Meta-analysis.pdf

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recordtype	eprints
spelling	iium-775622020-01-10T04:13:45Z http://irep.iium.edu.my/77562/ Effect of curcumin dose, treatment duration and intervention type on tumor inhibition in animal models: a systematic literature review using meta-analysis techniques Nasruddin, Arina Amid, Azura TP248.13 Biotechnology Curcuma longa L. uses widely as a traditional medicine especially in India and China for the treatment of diabetic wounds, inflammatory, hepatic, and digestive disorders. These effects lead to the research of this plant for the treatment of chronic diseases. To assess the tumour inhibition effect of curcumin in animal models by integrating various studies into a systematic literature review (SLR) and meta-analysis. Studies of curcumin treatment in tumor-induced animal models were searched in electronic databases. The assessment of the quality of the studies included and the tumor inhibition effect used SYRCLE’s Risk of Bias tool and Review Manager (The Cochrane Collaboration) software. From the 732 articles identified, only 11 studies met the selection criteria and included in the analysis. Curcumin significantly inhibited the tumor volume in the animal models in overall, and the subgroup analyses revealed that high dose, long-duration curcumin treatment, and intervention by injection have a more significant effect compared to the opposite group. Curcumin was effective in inhibiting tumor volume in animal models. The study quality and heterogeneity of the meta-analysis can probably be improved if a larger-scale bases of animal models and a well-designed study were available. IIUM Press 2019-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/77562/1/View%20of%20Effect%20of%20Curcumin%20Dose%2C%20Treatment%20Duration%20and%20Intervention%20Type%20on%20Tumor%20Inhibition%20in%20Animal%20Models_%20A%20Systematic%20Review%20and%20Meta-analysis.pdf Nasruddin, Arina and Amid, Azura (2019) Effect of curcumin dose, treatment duration and intervention type on tumor inhibition in animal models: a systematic literature review using meta-analysis techniques. Biological and Natural Resources Engineering Journal, 2 (2). pp. 1-12. E-ISSN 2637-0719 https://journals.iium.edu.my/bnrej/index.php/bnrej/article/view/33/20
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	TP248.13 Biotechnology
spellingShingle	TP248.13 Biotechnology Nasruddin, Arina Amid, Azura Effect of curcumin dose, treatment duration and intervention type on tumor inhibition in animal models: a systematic literature review using meta-analysis techniques
description	Curcuma longa L. uses widely as a traditional medicine especially in India and China for the treatment of diabetic wounds, inflammatory, hepatic, and digestive disorders. These effects lead to the research of this plant for the treatment of chronic diseases. To assess the tumour inhibition effect of curcumin in animal models by integrating various studies into a systematic literature review (SLR) and meta-analysis. Studies of curcumin treatment in tumor-induced animal models were searched in electronic databases. The assessment of the quality of the studies included and the tumor inhibition effect used SYRCLE’s Risk of Bias tool and Review Manager (The Cochrane Collaboration) software. From the 732 articles identified, only 11 studies met the selection criteria and included in the analysis. Curcumin significantly inhibited the tumor volume in the animal models in overall, and the subgroup analyses revealed that high dose, long-duration curcumin treatment, and intervention by injection have a more significant effect compared to the opposite group. Curcumin was effective in inhibiting tumor volume in animal models. The study quality and heterogeneity of the meta-analysis can probably be improved if a larger-scale bases of animal models and a well-designed study were available.
format	Article
author	Nasruddin, Arina Amid, Azura
author_facet	Nasruddin, Arina Amid, Azura
author_sort	Nasruddin, Arina
title	Effect of curcumin dose, treatment duration and intervention type on tumor inhibition in animal models: a systematic literature review using meta-analysis techniques
title_short	Effect of curcumin dose, treatment duration and intervention type on tumor inhibition in animal models: a systematic literature review using meta-analysis techniques
title_full	Effect of curcumin dose, treatment duration and intervention type on tumor inhibition in animal models: a systematic literature review using meta-analysis techniques
title_fullStr	Effect of curcumin dose, treatment duration and intervention type on tumor inhibition in animal models: a systematic literature review using meta-analysis techniques
title_full_unstemmed	Effect of curcumin dose, treatment duration and intervention type on tumor inhibition in animal models: a systematic literature review using meta-analysis techniques
title_sort	effect of curcumin dose, treatment duration and intervention type on tumor inhibition in animal models: a systematic literature review using meta-analysis techniques
publisher	IIUM Press
publishDate	2019
url	http://irep.iium.edu.my/77562/ http://irep.iium.edu.my/77562/ http://irep.iium.edu.my/77562/1/View%20of%20Effect%20of%20Curcumin%20Dose%2C%20Treatment%20Duration%20and%20Intervention%20Type%20on%20Tumor%20Inhibition%20in%20Animal%20Models_%20A%20Systematic%20Review%20and%20Meta-analysis.pdf
first_indexed	2023-09-18T21:49:24Z
last_indexed	2023-09-18T21:49:24Z
_version_	1777413667264921600

Effect of curcumin dose, treatment duration and intervention type on tumor inhibition in animal models: a systematic literature review using meta-analysis techniques

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