Cytotoxic activities of extracts and isolated compounds of some potential Sumatran medicinal plants against MCF-7 and HSC-3 cell lines

In continuation of our study of Sumatran plants and the bioactivity of their constituents, Stereocaulon halei Lamb (Stereocaulaceae) was extracted and isolated to obtain atranorin (1), lobaric acid (6), and methyl-β-orcinol carboxylate (9). We also prepared methanolic extracts of some Sumatran medic...

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Main Authors:	Andania, Meiridha Mutiara, Ismed, Friardi, Bakhtiar, M. Taher, Arief Ichwan, Solachuddin Jauhari, Bakhtiar, Amri, Arbain, Dayar
Format:	Article
Language:	English English English
Published:	Institute for Research and Community Services, Institut Teknologi Bandung 2019
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/77906/ http://irep.iium.edu.my/77906/ http://irep.iium.edu.my/77906/ http://irep.iium.edu.my/77906/1/J%20math%20fund%20sci.pdf http://irep.iium.edu.my/77906/7/77906_Cytotoxic%20activities%20of%20extracts_scopus.pdf http://irep.iium.edu.my/77906/8/77906_Cytotoxic%20activities%20of%20extracts_wos.pdf

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spelling	iium-779062020-03-13T07:19:22Z http://irep.iium.edu.my/77906/ Cytotoxic activities of extracts and isolated compounds of some potential Sumatran medicinal plants against MCF-7 and HSC-3 cell lines Andania, Meiridha Mutiara Ismed, Friardi Bakhtiar, M. Taher Arief Ichwan, Solachuddin Jauhari Bakhtiar, Amri Arbain, Dayar RS Pharmacy and materia medica In continuation of our study of Sumatran plants and the bioactivity of their constituents, Stereocaulon halei Lamb (Stereocaulaceae) was extracted and isolated to obtain atranorin (1), lobaric acid (6), and methyl-β-orcinol carboxylate (9). We also prepared methanolic extracts of some Sumatran medicinal plants, i.e. Alpinia denticulata, Alpinia malaccensis, Alpinia submutica, Curcuma zedoaria, Centella asiatia, Mangifera indica, Piper crocatum, Mussaenda frondosa, together with previously isolated compounds, i.e. crocatin A (2) and crocatin B (3) from P. crocatum, curcumin (4) from Curcuma longa, demethoxymatteucinol (5) from Sphaerostephanos polycarpus, mangiferin (7) from M. indica, methyl caffeate (8) from Balanophora elongata, tiliroside (10) from Guazuma ulmifolia, and usnic acid from Usnea sp (11). These extracts and compounds were tested for their cytotoxicity against MCF-7 and HSC-3 cell lines by MTT assay (3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide). It was found that the IC50 value of atranorin (1), lobaric acid (6), methyl-β-orcinol carboxylate (9), and methanolic extract of A. submutica towards the MCF-7 cell line was 208.20 μM, 172.05 μM, 382.60 μM and 70.95 μg/mL, respectively. The IC50 value of lobaric acid (6) and methyl-β- orcinol carboxylate (9) against the HSC-3 cell line was 88.92 μM and 260.09 μM, respectively. The other extracts did not show significant cytotoxicity. Institute for Research and Community Services, Institut Teknologi Bandung 2019-04-05 Article PeerReviewed application/pdf en http://irep.iium.edu.my/77906/1/J%20math%20fund%20sci.pdf application/pdf en http://irep.iium.edu.my/77906/7/77906_Cytotoxic%20activities%20of%20extracts_scopus.pdf application/pdf en http://irep.iium.edu.my/77906/8/77906_Cytotoxic%20activities%20of%20extracts_wos.pdf Andania, Meiridha Mutiara and Ismed, Friardi and Bakhtiar, M. Taher and Arief Ichwan, Solachuddin Jauhari and Bakhtiar, Amri and Arbain, Dayar (2019) Cytotoxic activities of extracts and isolated compounds of some potential Sumatran medicinal plants against MCF-7 and HSC-3 cell lines. Journal of Mathematical and Fundamental Sciences, 51 (3). pp. 225-242. ISSN 2337-5760 E-ISSN 2338-5510 http://journals.itb.ac.id/index.php/jmfs 10.5614/j.math.fund.sci.2019.51.3.2
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Andania, Meiridha Mutiara Ismed, Friardi Bakhtiar, M. Taher Arief Ichwan, Solachuddin Jauhari Bakhtiar, Amri Arbain, Dayar Cytotoxic activities of extracts and isolated compounds of some potential Sumatran medicinal plants against MCF-7 and HSC-3 cell lines
description	In continuation of our study of Sumatran plants and the bioactivity of their constituents, Stereocaulon halei Lamb (Stereocaulaceae) was extracted and isolated to obtain atranorin (1), lobaric acid (6), and methyl-β-orcinol carboxylate (9). We also prepared methanolic extracts of some Sumatran medicinal plants, i.e. Alpinia denticulata, Alpinia malaccensis, Alpinia submutica, Curcuma zedoaria, Centella asiatia, Mangifera indica, Piper crocatum, Mussaenda frondosa, together with previously isolated compounds, i.e. crocatin A (2) and crocatin B (3) from P. crocatum, curcumin (4) from Curcuma longa, demethoxymatteucinol (5) from Sphaerostephanos polycarpus, mangiferin (7) from M. indica, methyl caffeate (8) from Balanophora elongata, tiliroside (10) from Guazuma ulmifolia, and usnic acid from Usnea sp (11). These extracts and compounds were tested for their cytotoxicity against MCF-7 and HSC-3 cell lines by MTT assay (3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide). It was found that the IC50 value of atranorin (1), lobaric acid (6), methyl-β-orcinol carboxylate (9), and methanolic extract of A. submutica towards the MCF-7 cell line was 208.20 μM, 172.05 μM, 382.60 μM and 70.95 μg/mL, respectively. The IC50 value of lobaric acid (6) and methyl-β- orcinol carboxylate (9) against the HSC-3 cell line was 88.92 μM and 260.09 μM, respectively. The other extracts did not show significant cytotoxicity.
format	Article
author	Andania, Meiridha Mutiara Ismed, Friardi Bakhtiar, M. Taher Arief Ichwan, Solachuddin Jauhari Bakhtiar, Amri Arbain, Dayar
author_facet	Andania, Meiridha Mutiara Ismed, Friardi Bakhtiar, M. Taher Arief Ichwan, Solachuddin Jauhari Bakhtiar, Amri Arbain, Dayar
author_sort	Andania, Meiridha Mutiara
title	Cytotoxic activities of extracts and isolated compounds of some potential Sumatran medicinal plants against MCF-7 and HSC-3 cell lines
title_short	Cytotoxic activities of extracts and isolated compounds of some potential Sumatran medicinal plants against MCF-7 and HSC-3 cell lines
title_full	Cytotoxic activities of extracts and isolated compounds of some potential Sumatran medicinal plants against MCF-7 and HSC-3 cell lines
title_fullStr	Cytotoxic activities of extracts and isolated compounds of some potential Sumatran medicinal plants against MCF-7 and HSC-3 cell lines
title_full_unstemmed	Cytotoxic activities of extracts and isolated compounds of some potential Sumatran medicinal plants against MCF-7 and HSC-3 cell lines
title_sort	cytotoxic activities of extracts and isolated compounds of some potential sumatran medicinal plants against mcf-7 and hsc-3 cell lines
publisher	Institute for Research and Community Services, Institut Teknologi Bandung
publishDate	2019
url	http://irep.iium.edu.my/77906/ http://irep.iium.edu.my/77906/ http://irep.iium.edu.my/77906/ http://irep.iium.edu.my/77906/1/J%20math%20fund%20sci.pdf http://irep.iium.edu.my/77906/7/77906_Cytotoxic%20activities%20of%20extracts_scopus.pdf http://irep.iium.edu.my/77906/8/77906_Cytotoxic%20activities%20of%20extracts_wos.pdf
first_indexed	2023-09-18T21:49:50Z
last_indexed	2023-09-18T21:49:50Z
_version_	1777413695290212352

Cytotoxic activities of extracts and isolated compounds of some potential Sumatran medicinal plants against MCF-7 and HSC-3 cell lines

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