Role of Vascular Endothelial Growth Factor (VEGF) and doppler sub-endometrial parameters as predictors of successful implantation in Intracytoplasmic Sperm Injection (ICSI) patients

Objective: to investigate the expression of vascular endothelial growth factor (VEGF) in patients having infertility due to low endometrial acceptance, and to correlate it to non-invasive ultrasound variables, endometrial thickness, and sub-endometrial Doppler parameters (PI, RI, Vs/Vd). Methods:...

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Main Authors:	Rahmatullah, Wafaa Salih, Al-Obaidi, Manal Taha, AL-Saadi, Wasan I., Selman, Mohammad Oda, Faisal, Ghasak Ghazi
Format:	Article
Language:	English
Published:	2020
Subjects:	RB Pathology
Online Access:	http://irep.iium.edu.my/78028/ http://irep.iium.edu.my/78028/ http://irep.iium.edu.my/78028/ http://irep.iium.edu.my/78028/1/78028_Role%20of%20Vascular%20Endothelial%20Growth%20Factor%20%28VEGF%29.pdf

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spelling	iium-780282020-01-28T08:54:05Z http://irep.iium.edu.my/78028/ Role of Vascular Endothelial Growth Factor (VEGF) and doppler sub-endometrial parameters as predictors of successful implantation in Intracytoplasmic Sperm Injection (ICSI) patients Rahmatullah, Wafaa Salih Al-Obaidi, Manal Taha AL-Saadi, Wasan I. Selman, Mohammad Oda Faisal, Ghasak Ghazi RB Pathology Objective: to investigate the expression of vascular endothelial growth factor (VEGF) in patients having infertility due to low endometrial acceptance, and to correlate it to non-invasive ultrasound variables, endometrial thickness, and sub-endometrial Doppler parameters (PI, RI, Vs/Vd). Methods: 80 women all under the age of 40 underwent ICSI-ET; all patients were exposed to ovarian stimulation protocols. The oocytes were retrieved using an ultrasound guide, and were fertilised via injection of sperm inside the follicle (ICSI). VEGF serum level was analysed at day of embryo transfer by ELIZA test, and sub-endometrial evaluation was conducted via two-dimension power Doppler ultrasound (2D PD-US), by measuring resistance index (RI) and pulsatility index (PI) on the day of embryo transfer. Results: There was a significantly higher VEGF level and endometrial thickness in pregnant (433± 207 and 9.72± 1.35) women, compared to non-pregnant (276± 165 and 8.95 ± 1.21) respectively as p-values were (0.001 and 0.01)). Additionally, there were significantly lower RI and PI in pregnant (0.584 ± 0.124 and 0.829 ± 0.301) women compared to non-pregnant (0.651±0.132 and 1.006±0.335) women, as p-values were (0.02 and 0.02, respectively). The level of E2 was on the day of embryo transfer and Vs/Vd in pregnant women (1402± 524 and 3.14 ± 3.75) and in the non-pregnant group (1296± 611 and 3.82 ± 3.07), as p-values were 0.41 and 0.38, respectively. Conclusion: The combined analysis of endometrial receptivity was completed, and the serum level of VEGF and sub-endometrial evaluation with 2D PD-US was defined by measuring resistance index (RI) and pulsatility index (PI) on the day of embryo transfer. These can serve as useful prognostic methods for the detection of endometrial receptivity and pregnancy outcomes in infertile women undergoing ICSI protocols, and will be helpful for candidate counselling about postponing embryo transfer and cryopreservation, which may serve as a better option, to be recommended for the next cycle, when achieving better endometrial Doppler parameters. 2020-01-06 Article PeerReviewed application/pdf en http://irep.iium.edu.my/78028/1/78028_Role%20of%20Vascular%20Endothelial%20Growth%20Factor%20%28VEGF%29.pdf Rahmatullah, Wafaa Salih and Al-Obaidi, Manal Taha and AL-Saadi, Wasan I. and Selman, Mohammad Oda and Faisal, Ghasak Ghazi (2020) Role of Vascular Endothelial Growth Factor (VEGF) and doppler sub-endometrial parameters as predictors of successful implantation in Intracytoplasmic Sperm Injection (ICSI) patients. Siriraj Medical Journal, 72 (1). pp. 33-40. ISSN 2228-8082 http://www.smj.si.mahidol.ac.th/sirirajmedj/index.php/smj/article/view/2910/2740 http://dx.doi.org/10.33192/Smj.2020.05
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RB Pathology
spellingShingle	RB Pathology Rahmatullah, Wafaa Salih Al-Obaidi, Manal Taha AL-Saadi, Wasan I. Selman, Mohammad Oda Faisal, Ghasak Ghazi Role of Vascular Endothelial Growth Factor (VEGF) and doppler sub-endometrial parameters as predictors of successful implantation in Intracytoplasmic Sperm Injection (ICSI) patients
description	Objective: to investigate the expression of vascular endothelial growth factor (VEGF) in patients having infertility due to low endometrial acceptance, and to correlate it to non-invasive ultrasound variables, endometrial thickness, and sub-endometrial Doppler parameters (PI, RI, Vs/Vd). Methods: 80 women all under the age of 40 underwent ICSI-ET; all patients were exposed to ovarian stimulation protocols. The oocytes were retrieved using an ultrasound guide, and were fertilised via injection of sperm inside the follicle (ICSI). VEGF serum level was analysed at day of embryo transfer by ELIZA test, and sub-endometrial evaluation was conducted via two-dimension power Doppler ultrasound (2D PD-US), by measuring resistance index (RI) and pulsatility index (PI) on the day of embryo transfer. Results: There was a significantly higher VEGF level and endometrial thickness in pregnant (433± 207 and 9.72± 1.35) women, compared to non-pregnant (276± 165 and 8.95 ± 1.21) respectively as p-values were (0.001 and 0.01)). Additionally, there were significantly lower RI and PI in pregnant (0.584 ± 0.124 and 0.829 ± 0.301) women compared to non-pregnant (0.651±0.132 and 1.006±0.335) women, as p-values were (0.02 and 0.02, respectively). The level of E2 was on the day of embryo transfer and Vs/Vd in pregnant women (1402± 524 and 3.14 ± 3.75) and in the non-pregnant group (1296± 611 and 3.82 ± 3.07), as p-values were 0.41 and 0.38, respectively. Conclusion: The combined analysis of endometrial receptivity was completed, and the serum level of VEGF and sub-endometrial evaluation with 2D PD-US was defined by measuring resistance index (RI) and pulsatility index (PI) on the day of embryo transfer. These can serve as useful prognostic methods for the detection of endometrial receptivity and pregnancy outcomes in infertile women undergoing ICSI protocols, and will be helpful for candidate counselling about postponing embryo transfer and cryopreservation, which may serve as a better option, to be recommended for the next cycle, when achieving better endometrial Doppler parameters.
format	Article
author	Rahmatullah, Wafaa Salih Al-Obaidi, Manal Taha AL-Saadi, Wasan I. Selman, Mohammad Oda Faisal, Ghasak Ghazi
author_facet	Rahmatullah, Wafaa Salih Al-Obaidi, Manal Taha AL-Saadi, Wasan I. Selman, Mohammad Oda Faisal, Ghasak Ghazi
author_sort	Rahmatullah, Wafaa Salih
title	Role of Vascular Endothelial Growth Factor (VEGF) and doppler sub-endometrial parameters as predictors of successful implantation in Intracytoplasmic Sperm Injection (ICSI) patients
title_short	Role of Vascular Endothelial Growth Factor (VEGF) and doppler sub-endometrial parameters as predictors of successful implantation in Intracytoplasmic Sperm Injection (ICSI) patients
title_full	Role of Vascular Endothelial Growth Factor (VEGF) and doppler sub-endometrial parameters as predictors of successful implantation in Intracytoplasmic Sperm Injection (ICSI) patients
title_fullStr	Role of Vascular Endothelial Growth Factor (VEGF) and doppler sub-endometrial parameters as predictors of successful implantation in Intracytoplasmic Sperm Injection (ICSI) patients
title_full_unstemmed	Role of Vascular Endothelial Growth Factor (VEGF) and doppler sub-endometrial parameters as predictors of successful implantation in Intracytoplasmic Sperm Injection (ICSI) patients
title_sort	role of vascular endothelial growth factor (vegf) and doppler sub-endometrial parameters as predictors of successful implantation in intracytoplasmic sperm injection (icsi) patients
publishDate	2020
url	http://irep.iium.edu.my/78028/ http://irep.iium.edu.my/78028/ http://irep.iium.edu.my/78028/ http://irep.iium.edu.my/78028/1/78028_Role%20of%20Vascular%20Endothelial%20Growth%20Factor%20%28VEGF%29.pdf
first_indexed	2023-09-18T21:49:59Z
last_indexed	2023-09-18T21:49:59Z
_version_	1777413704065744896

Role of Vascular Endothelial Growth Factor (VEGF) and doppler sub-endometrial parameters as predictors of successful implantation in Intracytoplasmic Sperm Injection (ICSI) patients

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