The crystal structure and cytotoxicity of Centrosymmetric Copper(II) complex derived from S-methyldithiocarbazate with isatin
Copper(II) complex of S-methyldithiocarbazate with isatin has been prepared and screened for their cytotoxic activities against MCF-7 (Human non-metastatic mammary gland adenocarcinoma cell line) and MDA-MB- 231 (Human metastatic mammary gland adenocarcinoma cell line). The compound crystallized in...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer New York LLC
2011
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/7867/ http://irep.iium.edu.my/7867/ http://irep.iium.edu.my/7867/ http://irep.iium.edu.my/7867/1/JOCC_41_1866-1871.pdf |
| Summary: | Copper(II) complex of S-methyldithiocarbazate with isatin has been prepared and screened for their cytotoxic activities against MCF-7 (Human non-metastatic mammary gland adenocarcinoma cell line) and MDA-MB- 231 (Human metastatic mammary gland adenocarcinoma cell line). The compound crystallized in an orthorhombic crystal system with a space group C 2cb and was found to be selectively active against MCF-7 cell line (Human nonmetastatic mammary gland adenocarcinoma cell line with an IC50 value 0.45 lg/mL. The crystal structure of this centrosymmetric Cu(SMISA)2 complex (SMISA = Schiff base formed by condensation reaction of S-methyldithiocarbazate with isatin) showed that the copper atom has a distorted square-planar geometry with the Schiff base coordinated to the metal ion as a uninegatively charged bidentate ligand through the azomethine nitrogen and thiolate sulfur. |
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