Alkaloids from Popowia perakensis King and their potential as Dipeptidyl peptidase IV (DPP IV) inhibitors

A study on the alkaloidal composition on the Malaysian Annonaceae species, i.e Popowia perakensis King has been carried out. Barks of Popowia perakensis were extracted with hexane, dichloromethane and methanol, respectively. Dichloromethane extract further underwent the acid base treatmen...

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Main Authors:	Syed Abdul Azziz, Saripah Salbiah, Mukhtar, Mat Ropi, A. Hadi, A. Hamid, Mhd Bakri, Yuhanis, Aldulaimi, Ahmed Kareem Obaid, Awang, Khalijah, Hashim, Yumi Zuhanis Has-Yun
Format:	Article
Language:	English English
Published:	A and V Publication 2019
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/78683/ http://irep.iium.edu.my/78683/ http://irep.iium.edu.my/78683/ http://irep.iium.edu.my/78683/9/78683_Alkaloids%20from%20Popowia%20perakensis_article_new.pdf http://irep.iium.edu.my/78683/2/78683_Alkaloids%20from%20Popowia%20perakensis_SCOPUS.pdf

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spelling	iium-786832020-02-19T01:01:55Z http://irep.iium.edu.my/78683/ Alkaloids from Popowia perakensis King and their potential as Dipeptidyl peptidase IV (DPP IV) inhibitors Syed Abdul Azziz, Saripah Salbiah Mukhtar, Mat Ropi A. Hadi, A. Hamid Mhd Bakri, Yuhanis Aldulaimi, Ahmed Kareem Obaid Awang, Khalijah Hashim, Yumi Zuhanis Has-Yun QD Chemistry A study on the alkaloidal composition on the Malaysian Annonaceae species, i.e Popowia perakensis King has been carried out. Barks of Popowia perakensis were extracted with hexane, dichloromethane and methanol, respectively. Dichloromethane extract further underwent the acid base treatment to give the alkaloidal crude extract. Isolation of compounds was carried out using various chromatography techniques including column chromatography and thin layer chromatography. Spectroscopic methods notably 1H, 13C NMR, IR, UV and GC-MS spectroscopy were utilized to identify pure compounds in addition to comparison of reported data. Two azaanthraquinones alkaloids namely cleistopholine 1 and 6-methoxycleistopholine 2 together with simple isoquinolone alkaloid, N-methylcorydaldine 3 had been isolated. All three alkaloids are known but they were isolated for the first time from this species. Cleistopholine 1 was tested for Dipeptidyl peptidase IV (DPP IV) inhibition to investigate its potential antidiabetic activities. Results revealed that this compound showed quite weak (6.26 %) inhibitory activities as compared to the positive control, Diprotin A (81.46 %). The quantity of the other two compounds was insufficient for the screening purposes. A and V Publication 2019 Article PeerReviewed application/pdf en http://irep.iium.edu.my/78683/9/78683_Alkaloids%20from%20Popowia%20perakensis_article_new.pdf application/pdf en http://irep.iium.edu.my/78683/2/78683_Alkaloids%20from%20Popowia%20perakensis_SCOPUS.pdf Syed Abdul Azziz, Saripah Salbiah and Mukhtar, Mat Ropi and A. Hadi, A. Hamid and Mhd Bakri, Yuhanis and Aldulaimi, Ahmed Kareem Obaid and Awang, Khalijah and Hashim, Yumi Zuhanis Has-Yun (2019) Alkaloids from Popowia perakensis King and their potential as Dipeptidyl peptidase IV (DPP IV) inhibitors. Research Journal of Pharmacy and Technology, 12 (1). pp. 113-116. ISSN 0974-3618 E-ISSN 0974-360X http://www.indianjournals.com/ijor.aspx?target=ijor:rjpt&volume=12&issue=1&article=022 10.5958/0974-360X.2019.00022.2
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QD Chemistry
spellingShingle	QD Chemistry Syed Abdul Azziz, Saripah Salbiah Mukhtar, Mat Ropi A. Hadi, A. Hamid Mhd Bakri, Yuhanis Aldulaimi, Ahmed Kareem Obaid Awang, Khalijah Hashim, Yumi Zuhanis Has-Yun Alkaloids from Popowia perakensis King and their potential as Dipeptidyl peptidase IV (DPP IV) inhibitors
description	A study on the alkaloidal composition on the Malaysian Annonaceae species, i.e Popowia perakensis King has been carried out. Barks of Popowia perakensis were extracted with hexane, dichloromethane and methanol, respectively. Dichloromethane extract further underwent the acid base treatment to give the alkaloidal crude extract. Isolation of compounds was carried out using various chromatography techniques including column chromatography and thin layer chromatography. Spectroscopic methods notably 1H, 13C NMR, IR, UV and GC-MS spectroscopy were utilized to identify pure compounds in addition to comparison of reported data. Two azaanthraquinones alkaloids namely cleistopholine 1 and 6-methoxycleistopholine 2 together with simple isoquinolone alkaloid, N-methylcorydaldine 3 had been isolated. All three alkaloids are known but they were isolated for the first time from this species. Cleistopholine 1 was tested for Dipeptidyl peptidase IV (DPP IV) inhibition to investigate its potential antidiabetic activities. Results revealed that this compound showed quite weak (6.26 %) inhibitory activities as compared to the positive control, Diprotin A (81.46 %). The quantity of the other two compounds was insufficient for the screening purposes.
format	Article
author	Syed Abdul Azziz, Saripah Salbiah Mukhtar, Mat Ropi A. Hadi, A. Hamid Mhd Bakri, Yuhanis Aldulaimi, Ahmed Kareem Obaid Awang, Khalijah Hashim, Yumi Zuhanis Has-Yun
author_facet	Syed Abdul Azziz, Saripah Salbiah Mukhtar, Mat Ropi A. Hadi, A. Hamid Mhd Bakri, Yuhanis Aldulaimi, Ahmed Kareem Obaid Awang, Khalijah Hashim, Yumi Zuhanis Has-Yun
author_sort	Syed Abdul Azziz, Saripah Salbiah
title	Alkaloids from Popowia perakensis King and their potential as Dipeptidyl peptidase IV (DPP IV) inhibitors
title_short	Alkaloids from Popowia perakensis King and their potential as Dipeptidyl peptidase IV (DPP IV) inhibitors
title_full	Alkaloids from Popowia perakensis King and their potential as Dipeptidyl peptidase IV (DPP IV) inhibitors
title_fullStr	Alkaloids from Popowia perakensis King and their potential as Dipeptidyl peptidase IV (DPP IV) inhibitors
title_full_unstemmed	Alkaloids from Popowia perakensis King and their potential as Dipeptidyl peptidase IV (DPP IV) inhibitors
title_sort	alkaloids from popowia perakensis king and their potential as dipeptidyl peptidase iv (dpp iv) inhibitors
publisher	A and V Publication
publishDate	2019
url	http://irep.iium.edu.my/78683/ http://irep.iium.edu.my/78683/ http://irep.iium.edu.my/78683/ http://irep.iium.edu.my/78683/9/78683_Alkaloids%20from%20Popowia%20perakensis_article_new.pdf http://irep.iium.edu.my/78683/2/78683_Alkaloids%20from%20Popowia%20perakensis_SCOPUS.pdf
first_indexed	2023-09-18T21:50:50Z
last_indexed	2023-09-18T21:50:50Z
_version_	1777413757383737344

Alkaloids from Popowia perakensis King and their potential as Dipeptidyl peptidase IV (DPP IV) inhibitors

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