Bone-graft interface in New Zealand White rabbit’s model: A novel Malaysian-made biomaterial, “osteopaste”

Injectable self-hardened synthetic bone cement (Osteopaste) was developed from limestone for the purpose to promote healing of bone fracture or in reconstructed bone defects. Excellent biocompatibility of biomaterial results in close cellular contact with biomaterial surface. The aim of this study w...

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Main Authors:	Zakaria@Mohamad, Zamzuri, Che Seman, Che Nor Zarida, Zulkifly, Ahmad Hafiz, Buyong, Zunariah, Awang, Mohd Shukrimi, Mohd Yusof, Nazri, Md Ralib, Azrina
Format:	Conference or Workshop Item
Language:	English English English English
Published:	2020
Subjects:	RD701 Orthopedics
Online Access:	http://irep.iium.edu.my/79130/ http://irep.iium.edu.my/79130/1/MTE%202020%20poster_Osteopaste.pdf http://irep.iium.edu.my/79130/2/SIJIL%20MTE%201.pdf http://irep.iium.edu.my/79130/3/MTE%202020%20General%20Agenda.pdf http://irep.iium.edu.my/79130/4/SIJIL%20MTE%202.pdf

id	iium-79130
recordtype	eprints
spelling	iium-791302020-02-25T07:53:53Z http://irep.iium.edu.my/79130/ Bone-graft interface in New Zealand White rabbit’s model: A novel Malaysian-made biomaterial, “osteopaste” Zakaria@Mohamad, Zamzuri Che Seman, Che Nor Zarida Zulkifly, Ahmad Hafiz Buyong, Zunariah Awang, Mohd Shukrimi Mohd Yusof, Nazri Md Ralib, Azrina RD701 Orthopedics Injectable self-hardened synthetic bone cement (Osteopaste) was developed from limestone for the purpose to promote healing of bone fracture or in reconstructed bone defects. Excellent biocompatibility of biomaterial results in close cellular contact with biomaterial surface. The aim of this study was to evaluate the bone cell response produced at the bone-biomaterial interface using light microscopy (LM) and scanning electron microscopy (SEM). Osteopaste was implanted in a critical size defect model in rabbits’ tibiae and then, compared with commercialized bone graft; JectOS (calcium phosphate) and MIIG-X3 (calcium sulphate). The animals were sacrificed at 6, 12 and 24 weeks post-surgery and bone tissues containing biomaterials were harvested. The specimens were then processed for viewing under LM and SEM to access the histological analysis, surface of biomaterials and biomaterial-bone interface. This visualization showed that no intervening soft tissue seen between new bone and Osteopaste which enable osteoblast cells adhered and spread on the surface of Osteopaste compared with JectOS and MIIG-X3. In conclusion, Osteopaste is biocompatible, osteoconductive and showed osteointegration with surrounding host bone to support ingrowth of new bone. 2020-02-22 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/79130/1/MTE%202020%20poster_Osteopaste.pdf application/pdf en http://irep.iium.edu.my/79130/2/SIJIL%20MTE%201.pdf application/pdf en http://irep.iium.edu.my/79130/3/MTE%202020%20General%20Agenda.pdf application/pdf en http://irep.iium.edu.my/79130/4/SIJIL%20MTE%202.pdf Zakaria@Mohamad, Zamzuri and Che Seman, Che Nor Zarida and Zulkifly, Ahmad Hafiz and Buyong, Zunariah and Awang, Mohd Shukrimi and Mohd Yusof, Nazri and Md Ralib, Azrina (2020) Bone-graft interface in New Zealand White rabbit’s model: A novel Malaysian-made biomaterial, “osteopaste”. In: Malaysia Terchnology Expo 2020, 19-22 February 2020, PWTC, Kuala Lumpur. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English English
topic	RD701 Orthopedics
spellingShingle	RD701 Orthopedics Zakaria@Mohamad, Zamzuri Che Seman, Che Nor Zarida Zulkifly, Ahmad Hafiz Buyong, Zunariah Awang, Mohd Shukrimi Mohd Yusof, Nazri Md Ralib, Azrina Bone-graft interface in New Zealand White rabbit’s model: A novel Malaysian-made biomaterial, “osteopaste”
description	Injectable self-hardened synthetic bone cement (Osteopaste) was developed from limestone for the purpose to promote healing of bone fracture or in reconstructed bone defects. Excellent biocompatibility of biomaterial results in close cellular contact with biomaterial surface. The aim of this study was to evaluate the bone cell response produced at the bone-biomaterial interface using light microscopy (LM) and scanning electron microscopy (SEM). Osteopaste was implanted in a critical size defect model in rabbits’ tibiae and then, compared with commercialized bone graft; JectOS (calcium phosphate) and MIIG-X3 (calcium sulphate). The animals were sacrificed at 6, 12 and 24 weeks post-surgery and bone tissues containing biomaterials were harvested. The specimens were then processed for viewing under LM and SEM to access the histological analysis, surface of biomaterials and biomaterial-bone interface. This visualization showed that no intervening soft tissue seen between new bone and Osteopaste which enable osteoblast cells adhered and spread on the surface of Osteopaste compared with JectOS and MIIG-X3. In conclusion, Osteopaste is biocompatible, osteoconductive and showed osteointegration with surrounding host bone to support ingrowth of new bone.
format	Conference or Workshop Item
author	Zakaria@Mohamad, Zamzuri Che Seman, Che Nor Zarida Zulkifly, Ahmad Hafiz Buyong, Zunariah Awang, Mohd Shukrimi Mohd Yusof, Nazri Md Ralib, Azrina
author_facet	Zakaria@Mohamad, Zamzuri Che Seman, Che Nor Zarida Zulkifly, Ahmad Hafiz Buyong, Zunariah Awang, Mohd Shukrimi Mohd Yusof, Nazri Md Ralib, Azrina
author_sort	Zakaria@Mohamad, Zamzuri
title	Bone-graft interface in New Zealand White rabbit’s model: A novel Malaysian-made biomaterial, “osteopaste”
title_short	Bone-graft interface in New Zealand White rabbit’s model: A novel Malaysian-made biomaterial, “osteopaste”
title_full	Bone-graft interface in New Zealand White rabbit’s model: A novel Malaysian-made biomaterial, “osteopaste”
title_fullStr	Bone-graft interface in New Zealand White rabbit’s model: A novel Malaysian-made biomaterial, “osteopaste”
title_full_unstemmed	Bone-graft interface in New Zealand White rabbit’s model: A novel Malaysian-made biomaterial, “osteopaste”
title_sort	bone-graft interface in new zealand white rabbit’s model: a novel malaysian-made biomaterial, “osteopaste”
publishDate	2020
url	http://irep.iium.edu.my/79130/ http://irep.iium.edu.my/79130/1/MTE%202020%20poster_Osteopaste.pdf http://irep.iium.edu.my/79130/2/SIJIL%20MTE%201.pdf http://irep.iium.edu.my/79130/3/MTE%202020%20General%20Agenda.pdf http://irep.iium.edu.my/79130/4/SIJIL%20MTE%202.pdf
first_indexed	2023-09-18T21:51:16Z
last_indexed	2023-09-18T21:51:16Z
_version_	1777413785274810368

Bone-graft interface in New Zealand White rabbit’s model: A novel Malaysian-made biomaterial, “osteopaste”

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