Cytotoxic and xanthine oxidase inhibitory activities of chemical constituents of alphonsea cylindrica king
This study aimed to investigate the chemical constituents from Alphonsea cylindrica as well as their cytotoxic and xanthine oxidase inhibitory activities. The chemical compounds were isolated and purified by various chromatographic techniques and their structures were elucidated via modern spectro...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
A and V Publication
2019
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/79578/ http://irep.iium.edu.my/79578/ http://irep.iium.edu.my/79578/ http://irep.iium.edu.my/79578/5/79578_Cytotoxic%20and%20Xanthine%20Oxidase%20Inhibitory_article_new.pdf http://irep.iium.edu.my/79578/2/79578_Cytotoxic%20and%20Xanthine%20Oxidase%20Inhibitory_scopus.pdf |
| Summary: | This study aimed to investigate the chemical constituents from Alphonsea cylindrica as well as their cytotoxic
and xanthine oxidase inhibitory activities. The chemical compounds were isolated and purified by various
chromatographic techniques and their structures were elucidated via modern spectroscopic techniques including
NMR, MS, IR, UV and comparison with literature. A study on the barks of A. cylindrica has found eleven
known compounds were identified as stigmasterol (1), isoursuline (2), cyathocaline (3), kinabaline (4),
muniranine (5), isooncodine (6), iraqiine (7), O-methylmoschatoline (8), kareemine (9), atherospermidine (10)
and N-methylouregidione (11). The cytotoxic effect of hexane, DCM and methanol of bark of A. cylindrica as
well as the isolated compounds; 1, 2, 3, 4, 5, 7, 8, 9 and 10 were estimated on MCF-7 human breast cancer cells
and isoursuline possessed the most potent inhibitory activity with IC50 value of 33 µg/ml. Eight compounds 1, 3,
4, 5, 6, 8, 10 and 11 displayed moderate inhibitory activity effect with IC50 < 100 μM against xanthine oxidase.
As a conclusion, eleven compounds have been isolated from the bark of A. cylindrica King. Some of the
compounds also showed potential against cytotoxicity and xanthine oxidase inhibitory activities. The findings of
this study can enhance the understanding of the chemotaxonomy aspect of the A. cylindrica as well as its
potential in traditional and modern medicine |
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