Cytotoxic and xanthine oxidase inhibitory activities of chemical constituents of alphonsea cylindrica king

This study aimed to investigate the chemical constituents from Alphonsea cylindrica as well as their cytotoxic and xanthine oxidase inhibitory activities. The chemical compounds were isolated and purified by various chromatographic techniques and their structures were elucidated via modern spectro...

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Main Authors:	Mhd Bakri, Yuhanis, Abdulaimi, Ahmed Kareem Obaid, Syed Abdul Azziz, Saripah Salbiah, Nafiah, Mohd Azlan, Abdulla Aowda, Saadon, Hazim, Muhammad, Awang, Khalijah, Hashim, Yumi Zuhanis Has-Yun, Abbas, Phirdaous
Format:	Article
Language:	English English
Published:	A and V Publication 2019
Subjects:	RC Internal medicine
Online Access:	http://irep.iium.edu.my/79578/ http://irep.iium.edu.my/79578/ http://irep.iium.edu.my/79578/ http://irep.iium.edu.my/79578/5/79578_Cytotoxic%20and%20Xanthine%20Oxidase%20Inhibitory_article_new.pdf http://irep.iium.edu.my/79578/2/79578_Cytotoxic%20and%20Xanthine%20Oxidase%20Inhibitory_scopus.pdf

id	iium-79578
recordtype	eprints
spelling	iium-795782020-03-16T09:14:09Z http://irep.iium.edu.my/79578/ Cytotoxic and xanthine oxidase inhibitory activities of chemical constituents of alphonsea cylindrica king Mhd Bakri, Yuhanis Abdulaimi, Ahmed Kareem Obaid Syed Abdul Azziz, Saripah Salbiah Nafiah, Mohd Azlan Abdulla Aowda, Saadon Hazim, Muhammad Awang, Khalijah Hashim, Yumi Zuhanis Has-Yun Abbas, Phirdaous RC Internal medicine This study aimed to investigate the chemical constituents from Alphonsea cylindrica as well as their cytotoxic and xanthine oxidase inhibitory activities. The chemical compounds were isolated and purified by various chromatographic techniques and their structures were elucidated via modern spectroscopic techniques including NMR, MS, IR, UV and comparison with literature. A study on the barks of A. cylindrica has found eleven known compounds were identified as stigmasterol (1), isoursuline (2), cyathocaline (3), kinabaline (4), muniranine (5), isooncodine (6), iraqiine (7), O-methylmoschatoline (8), kareemine (9), atherospermidine (10) and N-methylouregidione (11). The cytotoxic effect of hexane, DCM and methanol of bark of A. cylindrica as well as the isolated compounds; 1, 2, 3, 4, 5, 7, 8, 9 and 10 were estimated on MCF-7 human breast cancer cells and isoursuline possessed the most potent inhibitory activity with IC50 value of 33 µg/ml. Eight compounds 1, 3, 4, 5, 6, 8, 10 and 11 displayed moderate inhibitory activity effect with IC50 < 100 μM against xanthine oxidase. As a conclusion, eleven compounds have been isolated from the bark of A. cylindrica King. Some of the compounds also showed potential against cytotoxicity and xanthine oxidase inhibitory activities. The findings of this study can enhance the understanding of the chemotaxonomy aspect of the A. cylindrica as well as its potential in traditional and modern medicine A and V Publication 2019-09 Article PeerReviewed application/pdf en http://irep.iium.edu.my/79578/5/79578_Cytotoxic%20and%20Xanthine%20Oxidase%20Inhibitory_article_new.pdf application/pdf en http://irep.iium.edu.my/79578/2/79578_Cytotoxic%20and%20Xanthine%20Oxidase%20Inhibitory_scopus.pdf Mhd Bakri, Yuhanis and Abdulaimi, Ahmed Kareem Obaid and Syed Abdul Azziz, Saripah Salbiah and Nafiah, Mohd Azlan and Abdulla Aowda, Saadon and Hazim, Muhammad and Awang, Khalijah and Hashim, Yumi Zuhanis Has-Yun and Abbas, Phirdaous (2019) Cytotoxic and xanthine oxidase inhibitory activities of chemical constituents of alphonsea cylindrica king. Research Journal of Pharmacy and Technology, 12 (9). pp. 4129-4134. ISSN 0974-3618 E-ISSN 0974-360X http://www.indianjournals.com/ijor.aspx?target=ijor:rjpt&volume=12&issue=9&article=013 10.5958/0974-360X.2019.00713.3
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RC Internal medicine
spellingShingle	RC Internal medicine Mhd Bakri, Yuhanis Abdulaimi, Ahmed Kareem Obaid Syed Abdul Azziz, Saripah Salbiah Nafiah, Mohd Azlan Abdulla Aowda, Saadon Hazim, Muhammad Awang, Khalijah Hashim, Yumi Zuhanis Has-Yun Abbas, Phirdaous Cytotoxic and xanthine oxidase inhibitory activities of chemical constituents of alphonsea cylindrica king
description	This study aimed to investigate the chemical constituents from Alphonsea cylindrica as well as their cytotoxic and xanthine oxidase inhibitory activities. The chemical compounds were isolated and purified by various chromatographic techniques and their structures were elucidated via modern spectroscopic techniques including NMR, MS, IR, UV and comparison with literature. A study on the barks of A. cylindrica has found eleven known compounds were identified as stigmasterol (1), isoursuline (2), cyathocaline (3), kinabaline (4), muniranine (5), isooncodine (6), iraqiine (7), O-methylmoschatoline (8), kareemine (9), atherospermidine (10) and N-methylouregidione (11). The cytotoxic effect of hexane, DCM and methanol of bark of A. cylindrica as well as the isolated compounds; 1, 2, 3, 4, 5, 7, 8, 9 and 10 were estimated on MCF-7 human breast cancer cells and isoursuline possessed the most potent inhibitory activity with IC50 value of 33 µg/ml. Eight compounds 1, 3, 4, 5, 6, 8, 10 and 11 displayed moderate inhibitory activity effect with IC50 < 100 μM against xanthine oxidase. As a conclusion, eleven compounds have been isolated from the bark of A. cylindrica King. Some of the compounds also showed potential against cytotoxicity and xanthine oxidase inhibitory activities. The findings of this study can enhance the understanding of the chemotaxonomy aspect of the A. cylindrica as well as its potential in traditional and modern medicine
format	Article
author	Mhd Bakri, Yuhanis Abdulaimi, Ahmed Kareem Obaid Syed Abdul Azziz, Saripah Salbiah Nafiah, Mohd Azlan Abdulla Aowda, Saadon Hazim, Muhammad Awang, Khalijah Hashim, Yumi Zuhanis Has-Yun Abbas, Phirdaous
author_facet	Mhd Bakri, Yuhanis Abdulaimi, Ahmed Kareem Obaid Syed Abdul Azziz, Saripah Salbiah Nafiah, Mohd Azlan Abdulla Aowda, Saadon Hazim, Muhammad Awang, Khalijah Hashim, Yumi Zuhanis Has-Yun Abbas, Phirdaous
author_sort	Mhd Bakri, Yuhanis
title	Cytotoxic and xanthine oxidase inhibitory activities of chemical constituents of alphonsea cylindrica king
title_short	Cytotoxic and xanthine oxidase inhibitory activities of chemical constituents of alphonsea cylindrica king
title_full	Cytotoxic and xanthine oxidase inhibitory activities of chemical constituents of alphonsea cylindrica king
title_fullStr	Cytotoxic and xanthine oxidase inhibitory activities of chemical constituents of alphonsea cylindrica king
title_full_unstemmed	Cytotoxic and xanthine oxidase inhibitory activities of chemical constituents of alphonsea cylindrica king
title_sort	cytotoxic and xanthine oxidase inhibitory activities of chemical constituents of alphonsea cylindrica king
publisher	A and V Publication
publishDate	2019
url	http://irep.iium.edu.my/79578/ http://irep.iium.edu.my/79578/ http://irep.iium.edu.my/79578/ http://irep.iium.edu.my/79578/5/79578_Cytotoxic%20and%20Xanthine%20Oxidase%20Inhibitory_article_new.pdf http://irep.iium.edu.my/79578/2/79578_Cytotoxic%20and%20Xanthine%20Oxidase%20Inhibitory_scopus.pdf
first_indexed	2023-09-18T21:51:35Z
last_indexed	2023-09-18T21:51:35Z
_version_	1777413804775178240

Cytotoxic and xanthine oxidase inhibitory activities of chemical constituents of alphonsea cylindrica king

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