Does connecting tobacco cessation intervention with tuberculosis care improve quality of life outcomes?
Objectives: The objective of this study was to document the impact of an integrated TB directly observed therapy short-course (DOTS) plus smoking cessation intervention (SCI) on HRQoL. Methods: This was a non-randomized controlled study (quasi experimental design) involving 120 TB patients who we...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Elsevier Inc.
2011
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/8836/ http://irep.iium.edu.my/8836/ http://irep.iium.edu.my/8836/4/PIN96-Poster-TB-Tobacco-QoL-ISPOR-2011-V2.pdf http://irep.iium.edu.my/8836/7/Value_in_Health.pdf |
| Summary: | Objectives: The objective of this study was to document the impact of an integrated TB directly
observed therapy short-course (DOTS) plus smoking cessation intervention (SCI) on HRQoL.
Methods: This was a non-randomized controlled study (quasi experimental design) involving
120 TB patients who were current smokers at the time of TB diagnosis. Patients were assigned to
either of two groups: conventional TB-DOTS plus smoking cessation intervention (SCIDOTS
group) or conventional TB-DOTS only (DOTS group). The effects of the novel intervention on
HRQoL were measured using EQ-5D questionnaire. Two-way repeated measure ANOVA was
used to examine the effects.
Results: When compared, participants who received the integrated intervention had a better
HRQoL than those who received the conventional TB care. The SCIDOTS group had a
significantly greater increase in EQ-5D utility score than the DOTS group during 6 months
follow-up (mean± SD = 0.98 ± 0.08 vs. 0.91 ± 0.14, p = 0.006). Similarly, the mean scores for
EQ-VAS showed a consistently similar trend as the EQ-5D indices, with the scores increasing
over the course of TB treatment. Furthermore, for the EQ-VAS, there were significant main
effects for group [F (1, 84) = 4.91, p = 0.029, η2 = 0.06], time [F (2, 168) = 139.50, p = <0.001, η2
= 0.62] and group x time interaction [F (2, 168) = 13.89, p = <0.001, η2 = 0.14].
Conclusions: This study provides evidence that an integrated TB-tobacco treatment strategy
could potentially improve overall quality of life outcomes among TB patients who are smokers. |
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