Natural quinolone antimicrobial agents from Malaysian Rutaceous species

Various 4-oxygenated and 2-substituted 4-quinolone alkaloids with diverse structural types have been isolated and were found unique to the Rutaceae plant family. Some of these alkaloids have been demonstrated to have promising antimicrobial activity. These alkaloids possess chromophore with some str...

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Main Authors:	Mohd Hassan, Norazian, Md Taib, Nurhaya, Mohd Kamal, Laina Zarisa, Abdul Karim, Khairul Anuar, May, Khin Soe
Format:	Conference or Workshop Item
Language:	English
Published:	2011
Subjects:	QD Chemistry QR180 Immunology RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/9699/ http://irep.iium.edu.my/9699/ http://irep.iium.edu.my/9699/1/ABSTRACTS.pdf

id	iium-9699
recordtype	eprints
spelling	iium-96992012-02-23T04:36:03Z http://irep.iium.edu.my/9699/ Natural quinolone antimicrobial agents from Malaysian Rutaceous species Mohd Hassan, Norazian Md Taib, Nurhaya Mohd Kamal, Laina Zarisa Abdul Karim, Khairul Anuar Abdul Karim, Khairul Anuar May, Khin Soe QD Chemistry QR180 Immunology RS Pharmacy and materia medica Various 4-oxygenated and 2-substituted 4-quinolone alkaloids with diverse structural types have been isolated and were found unique to the Rutaceae plant family. Some of these alkaloids have been demonstrated to have promising antimicrobial activity. These alkaloids possess chromophore with some structural similarities to that of the pharmacophore of the conventional 4-quinolone antimicrobial agents. Therefore it is presumed that this type of natural quinolone alkaloid could also share the same activity as the conventional agents. Three Malaysian Rutaceous species have been investigated for their natural quinolone antimicrobial agents, namely Glycosmis pentaphylla (Retz.) DC., Lunasia amara Blanco and Ruta angustifolia (L.) Pers. Bioassay-guided isolation facilitated by using bioautographic agar overlay assay against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 35213 and Candida albicans ATCC 90028 as the indicator microbes has led to the isolation of antimicrobial 4-quinozolone alkaloid, identified as arborine, 2-quinolone namely lunidonine and 4-quinolone with the trivial name graveoline from G. pentaphylla, L. amara and R. angustifolia, respectively. These alkaloids possess promising antimicrobial activity with the minimum inhibitory concentrations (MICs) ranging between 125 µg/ml and 250 µg/ml against the tested microbes. Arborine and graveoline showed synergistic antimicrobial effect when tested in combination with ampicillin against E. coli with FIC index of 0.38 for each combination. These results show a great importance in view of finding a new structural type in overcoming the emergence of quinolone resistance against some microbes which has been a disturbing feature of microbial infections. 2011-02-09 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/9699/1/ABSTRACTS.pdf Mohd Hassan, Norazian and Md Taib, Nurhaya and Mohd Kamal, Laina Zarisa and Abdul Karim, Khairul Anuar and Abdul Karim, Khairul Anuar and May, Khin Soe (2011) Natural quinolone antimicrobial agents from Malaysian Rutaceous species. In: IIUM Research, Invention and Innovation Exhibition IRIIE 2011, 9-10 February 2011, Kuala Lumpur, Malaysia. http://www.iium.edu.my/irie/11
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QD Chemistry QR180 Immunology RS Pharmacy and materia medica
spellingShingle	QD Chemistry QR180 Immunology RS Pharmacy and materia medica Mohd Hassan, Norazian Md Taib, Nurhaya Mohd Kamal, Laina Zarisa Abdul Karim, Khairul Anuar Abdul Karim, Khairul Anuar May, Khin Soe Natural quinolone antimicrobial agents from Malaysian Rutaceous species
description	Various 4-oxygenated and 2-substituted 4-quinolone alkaloids with diverse structural types have been isolated and were found unique to the Rutaceae plant family. Some of these alkaloids have been demonstrated to have promising antimicrobial activity. These alkaloids possess chromophore with some structural similarities to that of the pharmacophore of the conventional 4-quinolone antimicrobial agents. Therefore it is presumed that this type of natural quinolone alkaloid could also share the same activity as the conventional agents. Three Malaysian Rutaceous species have been investigated for their natural quinolone antimicrobial agents, namely Glycosmis pentaphylla (Retz.) DC., Lunasia amara Blanco and Ruta angustifolia (L.) Pers. Bioassay-guided isolation facilitated by using bioautographic agar overlay assay against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 35213 and Candida albicans ATCC 90028 as the indicator microbes has led to the isolation of antimicrobial 4-quinozolone alkaloid, identified as arborine, 2-quinolone namely lunidonine and 4-quinolone with the trivial name graveoline from G. pentaphylla, L. amara and R. angustifolia, respectively. These alkaloids possess promising antimicrobial activity with the minimum inhibitory concentrations (MICs) ranging between 125 µg/ml and 250 µg/ml against the tested microbes. Arborine and graveoline showed synergistic antimicrobial effect when tested in combination with ampicillin against E. coli with FIC index of 0.38 for each combination. These results show a great importance in view of finding a new structural type in overcoming the emergence of quinolone resistance against some microbes which has been a disturbing feature of microbial infections.
format	Conference or Workshop Item
author	Mohd Hassan, Norazian Md Taib, Nurhaya Mohd Kamal, Laina Zarisa Abdul Karim, Khairul Anuar Abdul Karim, Khairul Anuar May, Khin Soe
author_facet	Mohd Hassan, Norazian Md Taib, Nurhaya Mohd Kamal, Laina Zarisa Abdul Karim, Khairul Anuar Abdul Karim, Khairul Anuar May, Khin Soe
author_sort	Mohd Hassan, Norazian
title	Natural quinolone antimicrobial agents from Malaysian Rutaceous species
title_short	Natural quinolone antimicrobial agents from Malaysian Rutaceous species
title_full	Natural quinolone antimicrobial agents from Malaysian Rutaceous species
title_fullStr	Natural quinolone antimicrobial agents from Malaysian Rutaceous species
title_full_unstemmed	Natural quinolone antimicrobial agents from Malaysian Rutaceous species
title_sort	natural quinolone antimicrobial agents from malaysian rutaceous species
publishDate	2011
url	http://irep.iium.edu.my/9699/ http://irep.iium.edu.my/9699/ http://irep.iium.edu.my/9699/1/ABSTRACTS.pdf
first_indexed	2023-09-18T20:19:18Z
last_indexed	2023-09-18T20:19:18Z
_version_	1777407999311085568

Natural quinolone antimicrobial agents from Malaysian Rutaceous species

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