HPLC profile and antihyperglycemic effect of ethanol extracts of Andrographis paniculata in normal and streptozotocin-induced diabetic rats
Andrographis paniculata is a Malaysian traditional herb for treatment of fever-causing diseases and diabetes. The aim of the present study was to examine the antihyperglycemic effects of different extracts (95, 50, and 20% ethanol extracts and water extracts) of A. paniculata in normal and stre...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer
2007
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/9885/ http://irep.iium.edu.my/9885/ http://irep.iium.edu.my/9885/ http://irep.iium.edu.my/9885/1/JNatMedRazak.pdf |
| Summary: | Andrographis paniculata is a Malaysian traditional
herb for treatment of fever-causing diseases and
diabetes. The aim of the present study was to examine the
antihyperglycemic effects of different extracts (95, 50, and
20% ethanol extracts and water extracts) of A. paniculata
in normal and streptozotocin-induced diabetic rats. Only
the treatment with 20% ethanol extract (at 1 g/kg for 7 h,
p.o.) significantly (P < 0.01) reduced the rise in blood
glucose levels in glucose-loaded rats. None of the different
extracts (at 1 g/kg for 7 h, p.o.) significantly (P > 0.05)
altered the blood glucose levels in normal and streptozotocin-
induced diabetic rats as compared to the control
group. However, administration of the 50 and 95% ethanol
extracts (at 1 g/kg for 14 days, p.o.) significantly
(P < 0.05) reduced fasting blood glucose and insulin levels
in normal and diabetic rats compared to the pre-treatment
level. HPLC profiles of the extracts were developed using
andrographolide (AP) as a marker. The amounts of AP in
95, 50, and 20% ethanol extracts and water extracts were
25.8, 19.4, 2.0, and 0.8 mg/g of dry weight, respectively. |
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