HPLC profile and antihyperglycemic effect of ethanol extracts of Andrographis paniculata in normal and streptozotocin-induced diabetic rats
Andrographis paniculata is a Malaysian traditional herb for treatment of fever-causing diseases and diabetes. The aim of the present study was to examine the antihyperglycemic effects of different extracts (95, 50, and 20% ethanol extracts and water extracts) of A. paniculata in normal and stre...
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2007
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| Online Access: | http://irep.iium.edu.my/9885/ http://irep.iium.edu.my/9885/ http://irep.iium.edu.my/9885/ http://irep.iium.edu.my/9885/1/JNatMedRazak.pdf |
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iium-98852013-07-12T06:51:39Z http://irep.iium.edu.my/9885/ HPLC profile and antihyperglycemic effect of ethanol extracts of Andrographis paniculata in normal and streptozotocin-induced diabetic rats Ahmad, Mariam Kasmuri, Abdul Razak Akowuah, Gabriel Akyirem Asmawi, Mohd Zaini Ismail, Zhari RM Therapeutics. Pharmacology Andrographis paniculata is a Malaysian traditional herb for treatment of fever-causing diseases and diabetes. The aim of the present study was to examine the antihyperglycemic effects of different extracts (95, 50, and 20% ethanol extracts and water extracts) of A. paniculata in normal and streptozotocin-induced diabetic rats. Only the treatment with 20% ethanol extract (at 1 g/kg for 7 h, p.o.) significantly (P < 0.01) reduced the rise in blood glucose levels in glucose-loaded rats. None of the different extracts (at 1 g/kg for 7 h, p.o.) significantly (P > 0.05) altered the blood glucose levels in normal and streptozotocin- induced diabetic rats as compared to the control group. However, administration of the 50 and 95% ethanol extracts (at 1 g/kg for 14 days, p.o.) significantly (P < 0.05) reduced fasting blood glucose and insulin levels in normal and diabetic rats compared to the pre-treatment level. HPLC profiles of the extracts were developed using andrographolide (AP) as a marker. The amounts of AP in 95, 50, and 20% ethanol extracts and water extracts were 25.8, 19.4, 2.0, and 0.8 mg/g of dry weight, respectively. Springer 2007-10 Article PeerReviewed application/pdf en http://irep.iium.edu.my/9885/1/JNatMedRazak.pdf Ahmad, Mariam and Kasmuri, Abdul Razak and Akowuah, Gabriel Akyirem and Asmawi, Mohd Zaini and Ismail, Zhari (2007) HPLC profile and antihyperglycemic effect of ethanol extracts of Andrographis paniculata in normal and streptozotocin-induced diabetic rats. Journal of Natural Medicines, 61 (4). pp. 422-429. ISSN 1861-0293 (O), 1340-3443 (P) http://link.springer.com/article/10.1007%2Fs11418-007-0157-4 10.1007/s11418-007-0157-4 |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
| collection |
Online Access |
| language |
English |
| topic |
RM Therapeutics. Pharmacology |
| spellingShingle |
RM Therapeutics. Pharmacology Ahmad, Mariam Kasmuri, Abdul Razak Akowuah, Gabriel Akyirem Asmawi, Mohd Zaini Ismail, Zhari HPLC profile and antihyperglycemic effect of ethanol extracts of Andrographis paniculata in normal and streptozotocin-induced diabetic rats |
| description |
Andrographis paniculata is a Malaysian traditional
herb for treatment of fever-causing diseases and
diabetes. The aim of the present study was to examine the
antihyperglycemic effects of different extracts (95, 50, and
20% ethanol extracts and water extracts) of A. paniculata
in normal and streptozotocin-induced diabetic rats. Only
the treatment with 20% ethanol extract (at 1 g/kg for 7 h,
p.o.) significantly (P < 0.01) reduced the rise in blood
glucose levels in glucose-loaded rats. None of the different
extracts (at 1 g/kg for 7 h, p.o.) significantly (P > 0.05)
altered the blood glucose levels in normal and streptozotocin-
induced diabetic rats as compared to the control
group. However, administration of the 50 and 95% ethanol
extracts (at 1 g/kg for 14 days, p.o.) significantly
(P < 0.05) reduced fasting blood glucose and insulin levels
in normal and diabetic rats compared to the pre-treatment
level. HPLC profiles of the extracts were developed using
andrographolide (AP) as a marker. The amounts of AP in
95, 50, and 20% ethanol extracts and water extracts were
25.8, 19.4, 2.0, and 0.8 mg/g of dry weight, respectively. |
| format |
Article |
| author |
Ahmad, Mariam Kasmuri, Abdul Razak Akowuah, Gabriel Akyirem Asmawi, Mohd Zaini Ismail, Zhari |
| author_facet |
Ahmad, Mariam Kasmuri, Abdul Razak Akowuah, Gabriel Akyirem Asmawi, Mohd Zaini Ismail, Zhari |
| author_sort |
Ahmad, Mariam |
| title |
HPLC profile and antihyperglycemic effect of ethanol extracts
of Andrographis paniculata in normal and streptozotocin-induced diabetic rats |
| title_short |
HPLC profile and antihyperglycemic effect of ethanol extracts
of Andrographis paniculata in normal and streptozotocin-induced diabetic rats |
| title_full |
HPLC profile and antihyperglycemic effect of ethanol extracts
of Andrographis paniculata in normal and streptozotocin-induced diabetic rats |
| title_fullStr |
HPLC profile and antihyperglycemic effect of ethanol extracts
of Andrographis paniculata in normal and streptozotocin-induced diabetic rats |
| title_full_unstemmed |
HPLC profile and antihyperglycemic effect of ethanol extracts
of Andrographis paniculata in normal and streptozotocin-induced diabetic rats |
| title_sort |
hplc profile and antihyperglycemic effect of ethanol extracts
of andrographis paniculata in normal and streptozotocin-induced diabetic rats |
| publisher |
Springer |
| publishDate |
2007 |
| url |
http://irep.iium.edu.my/9885/ http://irep.iium.edu.my/9885/ http://irep.iium.edu.my/9885/ http://irep.iium.edu.my/9885/1/JNatMedRazak.pdf |
| first_indexed |
2023-09-18T20:19:28Z |
| last_indexed |
2023-09-18T20:19:28Z |
| _version_ |
1777408009859760128 |