Preservation of behavioural functions by haruan traditional extract (HTE) in rats with ketamine-induced neurodegeneration

INTRODUCTION Behavioural dysfunction presents as a significant problem in ketamine-induced brain damage. Restoration of brain functions following neurodegenerative damage may be possible using a neurorestorative agent with good lipophilicity, antioxidative and neuromodulatory properties. One such ag...

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Main Authors:	Mohd Shafri, Mohd Affendi, Mohamed, Farahidah, Md. Jaffri, Juliana, AM, Mat Jais
Format:	Conference or Workshop Item
Language:	English
Published:	2011
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/9990/ http://irep.iium.edu.my/9990/1/poster_IHCI_2011.pptx

id	iium-9990
recordtype	eprints
spelling	iium-99902013-01-14T06:48:21Z http://irep.iium.edu.my/9990/ Preservation of behavioural functions by haruan traditional extract (HTE) in rats with ketamine-induced neurodegeneration Mohd Shafri, Mohd Affendi Mohamed, Farahidah Md. Jaffri, Juliana AM, Mat Jais RS Pharmacy and materia medica INTRODUCTION Behavioural dysfunction presents as a significant problem in ketamine-induced brain damage. Restoration of brain functions following neurodegenerative damage may be possible using a neurorestorative agent with good lipophilicity, antioxidative and neuromodulatory properties. One such agent, haruan traditional extract (HTE), has been indicated as a neuroregenerative agent in in vitro study using PC12 cells and here is studied for its neuroprotective property. MATERIALS & METHODS The neuroprotective assay involves HTE (oral, 100ul/100mg body weight, once daily for 6 weeks) being given to Sprague Dawley (male, 7-8 weeks old, 150-200 gram), prior to induction of neurodegeneration by ketamine. Ketamine (i.p., 20mg/kg body weight, 4 times daily at 2 hourly interval) is given as either short exposure (1 day) or long exposure (5 days). Neurobehavioural test using hole board maze (5 minutes, 40cm x 40 cm Plexiglass raised floor, 16 x 3 cm diameter holes) was done to assess functions such as nose dipping and rearing activities. RESULT AND DISCUSSION Restoration of nose dipping and rearing activities show significant differences between short and long ketamine exposure group. CONCLUSION Statistical analyses comparing the groups indicate that HTE may be able to exert neuroprotective effect. 2011 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/9990/1/poster_IHCI_2011.pptx Mohd Shafri, Mohd Affendi and Mohamed, Farahidah and Md. Jaffri, Juliana and AM, Mat Jais (2011) Preservation of behavioural functions by haruan traditional extract (HTE) in rats with ketamine-induced neurodegeneration. In: International Health Conference IIUM 2011, 7-8 Dec 2011, Hotel Vistana, Kuantan, Pahang, Malaysia.
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Mohd Shafri, Mohd Affendi Mohamed, Farahidah Md. Jaffri, Juliana AM, Mat Jais Preservation of behavioural functions by haruan traditional extract (HTE) in rats with ketamine-induced neurodegeneration
description	INTRODUCTION Behavioural dysfunction presents as a significant problem in ketamine-induced brain damage. Restoration of brain functions following neurodegenerative damage may be possible using a neurorestorative agent with good lipophilicity, antioxidative and neuromodulatory properties. One such agent, haruan traditional extract (HTE), has been indicated as a neuroregenerative agent in in vitro study using PC12 cells and here is studied for its neuroprotective property. MATERIALS & METHODS The neuroprotective assay involves HTE (oral, 100ul/100mg body weight, once daily for 6 weeks) being given to Sprague Dawley (male, 7-8 weeks old, 150-200 gram), prior to induction of neurodegeneration by ketamine. Ketamine (i.p., 20mg/kg body weight, 4 times daily at 2 hourly interval) is given as either short exposure (1 day) or long exposure (5 days). Neurobehavioural test using hole board maze (5 minutes, 40cm x 40 cm Plexiglass raised floor, 16 x 3 cm diameter holes) was done to assess functions such as nose dipping and rearing activities. RESULT AND DISCUSSION Restoration of nose dipping and rearing activities show significant differences between short and long ketamine exposure group. CONCLUSION Statistical analyses comparing the groups indicate that HTE may be able to exert neuroprotective effect.
format	Conference or Workshop Item
author	Mohd Shafri, Mohd Affendi Mohamed, Farahidah Md. Jaffri, Juliana AM, Mat Jais
author_facet	Mohd Shafri, Mohd Affendi Mohamed, Farahidah Md. Jaffri, Juliana AM, Mat Jais
author_sort	Mohd Shafri, Mohd Affendi
title	Preservation of behavioural functions by haruan traditional extract (HTE) in rats with ketamine-induced neurodegeneration
title_short	Preservation of behavioural functions by haruan traditional extract (HTE) in rats with ketamine-induced neurodegeneration
title_full	Preservation of behavioural functions by haruan traditional extract (HTE) in rats with ketamine-induced neurodegeneration
title_fullStr	Preservation of behavioural functions by haruan traditional extract (HTE) in rats with ketamine-induced neurodegeneration
title_full_unstemmed	Preservation of behavioural functions by haruan traditional extract (HTE) in rats with ketamine-induced neurodegeneration
title_sort	preservation of behavioural functions by haruan traditional extract (hte) in rats with ketamine-induced neurodegeneration
publishDate	2011
url	http://irep.iium.edu.my/9990/ http://irep.iium.edu.my/9990/1/poster_IHCI_2011.pptx
first_indexed	2023-09-18T20:19:44Z
last_indexed	2023-09-18T20:19:44Z
_version_	1777408026213351424

Preservation of behavioural functions by haruan traditional extract (HTE) in rats with ketamine-induced neurodegeneration

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