The Epidemiological Impact of an HIV Vaccine on the HIV/AIDS Epidemic in Southern India
The potential epidemiological impact of preventive HIV vaccines on the HIV epidemic in Southern India is examined using a mathematical deterministic dynamic compartmental model. Various assumptions about the degree of protection offered by such a v...
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| Format: | Policy Research Working Paper |
| Language: | English en_US |
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World Bank, Washington, DC
2014
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| Online Access: | http://documents.worldbank.org/curated/en/2003/02/2160788/epidemiological-impact-hiv-vaccine-hivaids-epidemic-southern-india http://hdl.handle.net/10986/19152 |
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okr-10986-191522021-04-23T14:03:42Z The Epidemiological Impact of an HIV Vaccine on the HIV/AIDS Epidemic in Southern India Nagelkerke, Nico J.D. De Vlas, Sake J. ADULT MEN ADULT POPULATION ADULT PREVALENCE AIDS PATIENTS AIDS VACCINE ASYMPTOMATIC INFECTIONS BEHAVIORAL RISK BIRTH RATE COMMERCIAL SEX COMMERCIAL SEX WORKER COMMERCIAL SEX WORKERS CONDOM PROMOTION CONDOM USE DEATH RATE DRUG USE DRUGS EFFECTIVE VACCINES EPIDEMIOLOGICAL STUDIES FEMALE SEX WORKERS GAY MEN HETEROSEXUAL TRANSMISSION HIGH RISK GROUPS HIGH- RISK HIGH- RISK GROUPS HIGH-RISK HIGH-RISK BEHAVIORS HIGH-RISK GROUPS HIGH-RISK POPULATIONS HIV HIV INFECTION HIV INFECTIONS HIV PREVALENCE HIV PREVENTION HIV PREVENTION INTERVENTIONS HIV TEST HIV TRANSMISSION HIV VACCINATION HIV VIRUS IMMUNE RESPONSE IMMUNITY IMMUNIZATION IMMUNOLOGY INTERVENTION MALE CIRCUMCISION MALE CLIENTS MOTHER-TO-CHILD MOTHER-TO-CHILD TRANSMISSION NATIONAL AIDS CONTROL NEW INFECTIONS PATIENTS PREVENTION EFFORTS PREVENTION STRATEGIES PUBLIC HEALTH PUBLIC SERVICES RATES OF CONDOM USE REDUCTION IN TRANSMISSION REDUNDANCY RISK BEHAVIOR RISK POPULATIONS RISKY SEX SAFER SEX SEX WITH MEN SEX WORK SEXUAL BEHAVIOR SEXUAL BEHAVIORS SEXUAL PARTNERS SEXUALLY ACTIVE SEXUALLY ACTIVE AGE GROUP SEXUALLY ACTIVE POPULATION SEXUALLY TRANSMITTED DISEASES SEXUALLY TRANSMITTED INFECTIONS STIS SYNDROMIC TREATMENT UNPROTECTED SEX UNSAFE SEX USE OF CONDOMS VACCINE PREVENTABLE DISEASES VACCINE RESEARCH VACCINES VERTICAL TRANSMISSION VULNERABLE GROUPS ACQUIRED IMMUNE DEFICIENCY SYNDROME HIV VIRUSES EPIDEMICS VACCINES DISEASE PREVENTION & CONTROL IMMUNOLOGY TARGETED ASSISTANCE SEXUAL BEHAVIOR HEALTH IMPACTS CONTRACEPTIVES The potential epidemiological impact of preventive HIV vaccines on the HIV epidemic in Southern India is examined using a mathematical deterministic dynamic compartmental model. Various assumptions about the degree of protection offered by such a vaccine, the extent of immunological response of those vaccinated, and the duration of protection afforded are explored. Alternative targeting strategies for HIV vaccination are simulated and compared with the impact of conventional prevention interventions in high-risk groups and the general population. The impact of disinhibition (increased risk behavior due to the presence of a vaccine) is also considered. Vaccines that convey a high degree of protection in a share of or all of those immunized and that convey life-long immunity are the most effective in curbing the HIV epidemic. Vaccines that convey less than complete protection may also have substantial public health impact, but disinhibition can easily undo their effects and they should be used combined with conventional prevention efforts. Conventional interventions that target commercial sex workers and their clients to increase condom use can also be highly effective and can be implemented immediately, before the arrival of vaccines. 2014-07-31T21:19:57Z 2014-07-31T21:19:57Z 2003-02 http://documents.worldbank.org/curated/en/2003/02/2160788/epidemiological-impact-hiv-vaccine-hivaids-epidemic-southern-india http://hdl.handle.net/10986/19152 English en_US Policy Research Working Paper;No. 2978 CC BY 3.0 IGO http://creativecommons.org/licenses/by/3.0/igo/ World Bank, Washington, DC Publications & Research :: Policy Research Working Paper Publications & Research South Asia India |
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Digital Repository |
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Foreign Institution |
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Digital Repositories |
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World Bank Open Knowledge Repository |
| collection |
World Bank |
| language |
English en_US |
| topic |
ADULT MEN ADULT POPULATION ADULT PREVALENCE AIDS PATIENTS AIDS VACCINE ASYMPTOMATIC INFECTIONS BEHAVIORAL RISK BIRTH RATE COMMERCIAL SEX COMMERCIAL SEX WORKER COMMERCIAL SEX WORKERS CONDOM PROMOTION CONDOM USE DEATH RATE DRUG USE DRUGS EFFECTIVE VACCINES EPIDEMIOLOGICAL STUDIES FEMALE SEX WORKERS GAY MEN HETEROSEXUAL TRANSMISSION HIGH RISK GROUPS HIGH- RISK HIGH- RISK GROUPS HIGH-RISK HIGH-RISK BEHAVIORS HIGH-RISK GROUPS HIGH-RISK POPULATIONS HIV HIV INFECTION HIV INFECTIONS HIV PREVALENCE HIV PREVENTION HIV PREVENTION INTERVENTIONS HIV TEST HIV TRANSMISSION HIV VACCINATION HIV VIRUS IMMUNE RESPONSE IMMUNITY IMMUNIZATION IMMUNOLOGY INTERVENTION MALE CIRCUMCISION MALE CLIENTS MOTHER-TO-CHILD MOTHER-TO-CHILD TRANSMISSION NATIONAL AIDS CONTROL NEW INFECTIONS PATIENTS PREVENTION EFFORTS PREVENTION STRATEGIES PUBLIC HEALTH PUBLIC SERVICES RATES OF CONDOM USE REDUCTION IN TRANSMISSION REDUNDANCY RISK BEHAVIOR RISK POPULATIONS RISKY SEX SAFER SEX SEX WITH MEN SEX WORK SEXUAL BEHAVIOR SEXUAL BEHAVIORS SEXUAL PARTNERS SEXUALLY ACTIVE SEXUALLY ACTIVE AGE GROUP SEXUALLY ACTIVE POPULATION SEXUALLY TRANSMITTED DISEASES SEXUALLY TRANSMITTED INFECTIONS STIS SYNDROMIC TREATMENT UNPROTECTED SEX UNSAFE SEX USE OF CONDOMS VACCINE PREVENTABLE DISEASES VACCINE RESEARCH VACCINES VERTICAL TRANSMISSION VULNERABLE GROUPS ACQUIRED IMMUNE DEFICIENCY SYNDROME HIV VIRUSES EPIDEMICS VACCINES DISEASE PREVENTION & CONTROL IMMUNOLOGY TARGETED ASSISTANCE SEXUAL BEHAVIOR HEALTH IMPACTS CONTRACEPTIVES |
| spellingShingle |
ADULT MEN ADULT POPULATION ADULT PREVALENCE AIDS PATIENTS AIDS VACCINE ASYMPTOMATIC INFECTIONS BEHAVIORAL RISK BIRTH RATE COMMERCIAL SEX COMMERCIAL SEX WORKER COMMERCIAL SEX WORKERS CONDOM PROMOTION CONDOM USE DEATH RATE DRUG USE DRUGS EFFECTIVE VACCINES EPIDEMIOLOGICAL STUDIES FEMALE SEX WORKERS GAY MEN HETEROSEXUAL TRANSMISSION HIGH RISK GROUPS HIGH- RISK HIGH- RISK GROUPS HIGH-RISK HIGH-RISK BEHAVIORS HIGH-RISK GROUPS HIGH-RISK POPULATIONS HIV HIV INFECTION HIV INFECTIONS HIV PREVALENCE HIV PREVENTION HIV PREVENTION INTERVENTIONS HIV TEST HIV TRANSMISSION HIV VACCINATION HIV VIRUS IMMUNE RESPONSE IMMUNITY IMMUNIZATION IMMUNOLOGY INTERVENTION MALE CIRCUMCISION MALE CLIENTS MOTHER-TO-CHILD MOTHER-TO-CHILD TRANSMISSION NATIONAL AIDS CONTROL NEW INFECTIONS PATIENTS PREVENTION EFFORTS PREVENTION STRATEGIES PUBLIC HEALTH PUBLIC SERVICES RATES OF CONDOM USE REDUCTION IN TRANSMISSION REDUNDANCY RISK BEHAVIOR RISK POPULATIONS RISKY SEX SAFER SEX SEX WITH MEN SEX WORK SEXUAL BEHAVIOR SEXUAL BEHAVIORS SEXUAL PARTNERS SEXUALLY ACTIVE SEXUALLY ACTIVE AGE GROUP SEXUALLY ACTIVE POPULATION SEXUALLY TRANSMITTED DISEASES SEXUALLY TRANSMITTED INFECTIONS STIS SYNDROMIC TREATMENT UNPROTECTED SEX UNSAFE SEX USE OF CONDOMS VACCINE PREVENTABLE DISEASES VACCINE RESEARCH VACCINES VERTICAL TRANSMISSION VULNERABLE GROUPS ACQUIRED IMMUNE DEFICIENCY SYNDROME HIV VIRUSES EPIDEMICS VACCINES DISEASE PREVENTION & CONTROL IMMUNOLOGY TARGETED ASSISTANCE SEXUAL BEHAVIOR HEALTH IMPACTS CONTRACEPTIVES Nagelkerke, Nico J.D. De Vlas, Sake J. The Epidemiological Impact of an HIV Vaccine on the HIV/AIDS Epidemic in Southern India |
| geographic_facet |
South Asia India |
| relation |
Policy Research Working Paper;No. 2978 |
| description |
The potential epidemiological impact of
preventive HIV vaccines on the HIV epidemic in Southern
India is examined using a mathematical deterministic dynamic
compartmental model. Various assumptions about the degree of
protection offered by such a vaccine, the extent of
immunological response of those vaccinated, and the duration
of protection afforded are explored. Alternative targeting
strategies for HIV vaccination are simulated and compared
with the impact of conventional prevention interventions in
high-risk groups and the general population. The impact of
disinhibition (increased risk behavior due to the presence
of a vaccine) is also considered. Vaccines that convey a
high degree of protection in a share of or all of those
immunized and that convey life-long immunity are the most
effective in curbing the HIV epidemic. Vaccines that convey
less than complete protection may also have substantial
public health impact, but disinhibition can easily undo
their effects and they should be used combined with
conventional prevention efforts. Conventional interventions
that target commercial sex workers and their clients to
increase condom use can also be highly effective and can be
implemented immediately, before the arrival of vaccines. |
| format |
Publications & Research :: Policy Research Working Paper |
| author |
Nagelkerke, Nico J.D. De Vlas, Sake J. |
| author_facet |
Nagelkerke, Nico J.D. De Vlas, Sake J. |
| author_sort |
Nagelkerke, Nico J.D. |
| title |
The Epidemiological Impact of an HIV Vaccine on the HIV/AIDS Epidemic in Southern India |
| title_short |
The Epidemiological Impact of an HIV Vaccine on the HIV/AIDS Epidemic in Southern India |
| title_full |
The Epidemiological Impact of an HIV Vaccine on the HIV/AIDS Epidemic in Southern India |
| title_fullStr |
The Epidemiological Impact of an HIV Vaccine on the HIV/AIDS Epidemic in Southern India |
| title_full_unstemmed |
The Epidemiological Impact of an HIV Vaccine on the HIV/AIDS Epidemic in Southern India |
| title_sort |
epidemiological impact of an hiv vaccine on the hiv/aids epidemic in southern india |
| publisher |
World Bank, Washington, DC |
| publishDate |
2014 |
| url |
http://documents.worldbank.org/curated/en/2003/02/2160788/epidemiological-impact-hiv-vaccine-hivaids-epidemic-southern-india http://hdl.handle.net/10986/19152 |
| _version_ |
1764439204206477312 |