Design of alginate nanoparticles as oral insulin carrier / Aminah Kadir

The relationship of high and low molecular weight mannuronic acid (M)- and guluronic acid (G)-rich alginate nanoparticles as oral insulin carrier was elucidated. Nanoparticles were prepared through ionotropic gelation using Ca2 +, and then in vitro physicochemical attributes and in vivo antidiabeti...

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Main Author:	Kadir, Aminah
Format:	Thesis
Language:	English
Published:	2015
Subjects:	Oral and dental medicine. Pathology. Diseases Pharmaceutical technology
Online Access:	http://ir.uitm.edu.my/id/eprint/13853/ http://ir.uitm.edu.my/id/eprint/13853/1/TM_AMINAH%20KADIR%20PH%2015_5%201.pdf

id	uitm-13853
recordtype	eprints
spelling	uitm-138532016-05-14T07:18:53Z http://ir.uitm.edu.my/id/eprint/13853/ Design of alginate nanoparticles as oral insulin carrier / Aminah Kadir Kadir, Aminah Oral and dental medicine. Pathology. Diseases Pharmaceutical technology The relationship of high and low molecular weight mannuronic acid (M)- and guluronic acid (G)-rich alginate nanoparticles as oral insulin carrier was elucidated. Nanoparticles were prepared through ionotropic gelation using Ca2 +, and then in vitro physicochemical attributes and in vivo antidiabetic characteristics were examined. The alginate nanoparticles had insulin release retarded when the matrices had high alginate-to-insulin ratio or strong alginate-insulin interaction via O-H moiety. High molecular weight M-rich alginate nanoparticles were characterized by assemblies of long polymer chains that enabled insulin encapsulation with weaker polymer-drug interaction than nanoparticles prepared from other alginate grades. They were able to encapsulate and yet release and have insulin absorbed into systemic circulation, thereby lowering rat blood glucose. High molecular weight G- and low molecular weight M-rich alginate nanoparticles showed remarkable polymer-insulin interaction. This retarded the drug release and negated its absorption. Blood glucose lowering was, however, demonstrated in vivo with insulin-free matrices of these nanoparticles because of the strong alginate-glucose binding that led to intestinal glucose retention. Alginate nanoparticles can be used as oral insulin carrier or glucose binder in the treatment of diabetes as a function of its chemical composition. High molecular weight M-rich alginate nanoparticles are a suitable vehicle for future development into oral insulin carrier 2015 Thesis NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/13853/1/TM_AMINAH%20KADIR%20PH%2015_5%201.pdf Kadir, Aminah (2015) Design of alginate nanoparticles as oral insulin carrier / Aminah Kadir. Masters thesis, Universiti Teknologi MARA.
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
topic	Oral and dental medicine. Pathology. Diseases Pharmaceutical technology
spellingShingle	Oral and dental medicine. Pathology. Diseases Pharmaceutical technology Kadir, Aminah Design of alginate nanoparticles as oral insulin carrier / Aminah Kadir
description	The relationship of high and low molecular weight mannuronic acid (M)- and guluronic acid (G)-rich alginate nanoparticles as oral insulin carrier was elucidated. Nanoparticles were prepared through ionotropic gelation using Ca2 +, and then in vitro physicochemical attributes and in vivo antidiabetic characteristics were examined. The alginate nanoparticles had insulin release retarded when the matrices had high alginate-to-insulin ratio or strong alginate-insulin interaction via O-H moiety. High molecular weight M-rich alginate nanoparticles were characterized by assemblies of long polymer chains that enabled insulin encapsulation with weaker polymer-drug interaction than nanoparticles prepared from other alginate grades. They were able to encapsulate and yet release and have insulin absorbed into systemic circulation, thereby lowering rat blood glucose. High molecular weight G- and low molecular weight M-rich alginate nanoparticles showed remarkable polymer-insulin interaction. This retarded the drug release and negated its absorption. Blood glucose lowering was, however, demonstrated in vivo with insulin-free matrices of these nanoparticles because of the strong alginate-glucose binding that led to intestinal glucose retention. Alginate nanoparticles can be used as oral insulin carrier or glucose binder in the treatment of diabetes as a function of its chemical composition. High molecular weight M-rich alginate nanoparticles are a suitable vehicle for future development into oral insulin carrier
format	Thesis
author	Kadir, Aminah
author_facet	Kadir, Aminah
author_sort	Kadir, Aminah
title	Design of alginate nanoparticles as oral insulin carrier / Aminah Kadir
title_short	Design of alginate nanoparticles as oral insulin carrier / Aminah Kadir
title_full	Design of alginate nanoparticles as oral insulin carrier / Aminah Kadir
title_fullStr	Design of alginate nanoparticles as oral insulin carrier / Aminah Kadir
title_full_unstemmed	Design of alginate nanoparticles as oral insulin carrier / Aminah Kadir
title_sort	design of alginate nanoparticles as oral insulin carrier / aminah kadir
publishDate	2015
url	http://ir.uitm.edu.my/id/eprint/13853/ http://ir.uitm.edu.my/id/eprint/13853/1/TM_AMINAH%20KADIR%20PH%2015_5%201.pdf
first_indexed	2023-09-18T22:50:25Z
last_indexed	2023-09-18T22:50:25Z
_version_	1777417506239021056

Design of alginate nanoparticles as oral insulin carrier / Aminah Kadir

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