Design of microcrystalline cellulose-free alginate spheroids by extrusion- spheronization technique / Siti Noorafifah Mohd Zolkefpeli

Conventional spheroid preparation by extrusion-spheronization technique requires microcrystalline cellulose (MCC) as processing aid to improve extrudability of wet mass and spheronization capacity of extrudates. The present study investigated formulation and processing attributes in extrusion and sp...

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Main Author:	Mohd Zolkefpeli, Siti Noorafifah
Format:	Thesis
Language:	English
Published:	2015
Subjects:	Materia medica
Online Access:	http://ir.uitm.edu.my/id/eprint/15234/ http://ir.uitm.edu.my/id/eprint/15234/1/TM_SITI%20NOORAFIFAH%20MOHD%20ZOLKEFPELI%20PH%2015_5.pdf

id	uitm-15234
recordtype	eprints
spelling	uitm-152342016-11-22T00:30:34Z http://ir.uitm.edu.my/id/eprint/15234/ Design of microcrystalline cellulose-free alginate spheroids by extrusion- spheronization technique / Siti Noorafifah Mohd Zolkefpeli Mohd Zolkefpeli, Siti Noorafifah Materia medica Conventional spheroid preparation by extrusion-spheronization technique requires microcrystalline cellulose (MCC) as processing aid to improve extrudability of wet mass and spheronization capacity of extrudates. The present study investigated formulation and processing attributes in extrusion and spheronization necessary for design of MCC-free alginate spheroids. The physicochemical characteristics of these spheroids were examined and compared against MCC-Ioaded alginate spheroids using chlorpheniramine maleate and tolbutamide as water-soluble and poorly water-soluble drugs respectively. Alginate spheroids demonstrated a slower release of hydrophilic drug due to ease of matrix swelling and aggregation in the absence of MCC. This reduced their specific surface area for drug dissolution. Crosslinking of alginate with soluble calcium densified the surface of spheroids and hindered matrix aggregation. It led to faster drug release from alginate than alginate-MCC spheroids. Fast drug release was also noted in spheroids embedded with hydrophobic drug when MCC was absent as drug adsorbent. A complete replacement ofMCC with alginate can promote or retard drug release of spheroids as a function of drug-polymer interaction and state of matrix swelling and aggregation 2015 Thesis NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/15234/1/TM_SITI%20NOORAFIFAH%20MOHD%20ZOLKEFPELI%20PH%2015_5.pdf Mohd Zolkefpeli, Siti Noorafifah (2015) Design of microcrystalline cellulose-free alginate spheroids by extrusion- spheronization technique / Siti Noorafifah Mohd Zolkefpeli. Masters thesis, Universiti Teknologi MARA.
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
topic	Materia medica
spellingShingle	Materia medica Mohd Zolkefpeli, Siti Noorafifah Design of microcrystalline cellulose-free alginate spheroids by extrusion- spheronization technique / Siti Noorafifah Mohd Zolkefpeli
description	Conventional spheroid preparation by extrusion-spheronization technique requires microcrystalline cellulose (MCC) as processing aid to improve extrudability of wet mass and spheronization capacity of extrudates. The present study investigated formulation and processing attributes in extrusion and spheronization necessary for design of MCC-free alginate spheroids. The physicochemical characteristics of these spheroids were examined and compared against MCC-Ioaded alginate spheroids using chlorpheniramine maleate and tolbutamide as water-soluble and poorly water-soluble drugs respectively. Alginate spheroids demonstrated a slower release of hydrophilic drug due to ease of matrix swelling and aggregation in the absence of MCC. This reduced their specific surface area for drug dissolution. Crosslinking of alginate with soluble calcium densified the surface of spheroids and hindered matrix aggregation. It led to faster drug release from alginate than alginate-MCC spheroids. Fast drug release was also noted in spheroids embedded with hydrophobic drug when MCC was absent as drug adsorbent. A complete replacement ofMCC with alginate can promote or retard drug release of spheroids as a function of drug-polymer interaction and state of matrix swelling and aggregation
format	Thesis
author	Mohd Zolkefpeli, Siti Noorafifah
author_facet	Mohd Zolkefpeli, Siti Noorafifah
author_sort	Mohd Zolkefpeli, Siti Noorafifah
title	Design of microcrystalline cellulose-free alginate spheroids by extrusion- spheronization technique / Siti Noorafifah Mohd Zolkefpeli
title_short	Design of microcrystalline cellulose-free alginate spheroids by extrusion- spheronization technique / Siti Noorafifah Mohd Zolkefpeli
title_full	Design of microcrystalline cellulose-free alginate spheroids by extrusion- spheronization technique / Siti Noorafifah Mohd Zolkefpeli
title_fullStr	Design of microcrystalline cellulose-free alginate spheroids by extrusion- spheronization technique / Siti Noorafifah Mohd Zolkefpeli
title_full_unstemmed	Design of microcrystalline cellulose-free alginate spheroids by extrusion- spheronization technique / Siti Noorafifah Mohd Zolkefpeli
title_sort	design of microcrystalline cellulose-free alginate spheroids by extrusion- spheronization technique / siti noorafifah mohd zolkefpeli
publishDate	2015
url	http://ir.uitm.edu.my/id/eprint/15234/ http://ir.uitm.edu.my/id/eprint/15234/1/TM_SITI%20NOORAFIFAH%20MOHD%20ZOLKEFPELI%20PH%2015_5.pdf
first_indexed	2023-09-18T22:53:23Z
last_indexed	2023-09-18T22:53:23Z
_version_	1777417693465411584

Design of microcrystalline cellulose-free alginate spheroids by extrusion- spheronization technique / Siti Noorafifah Mohd Zolkefpeli

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