Toxicity profiling of gold and iron oxide nanoparticles as a radiographic contrast media / Muhamad Idham Mohamed

Exponential growth of nanotechnology has led to a tremendous research and development to exploit their novel properties in various fields including diagnostic imaging. To date, iodine has been clinically used as a radiographic contrast medium. However, raising concern of iodine threats lead to an ex...

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Main Author:	Mohamed, Muhamad Idham
Format:	Thesis
Language:	English
Published:	2015
Subjects:	Radiation physics (General)
Online Access:	http://ir.uitm.edu.my/id/eprint/15852/ http://ir.uitm.edu.my/id/eprint/15852/1/TM_MUHAMAD%20IDHAM%20MOHAMED%20HS%2015_5.pdf

id	uitm-15852
recordtype	eprints
spelling	uitm-158522016-12-16T07:27:29Z http://ir.uitm.edu.my/id/eprint/15852/ Toxicity profiling of gold and iron oxide nanoparticles as a radiographic contrast media / Muhamad Idham Mohamed Mohamed, Muhamad Idham Radiation physics (General) Exponential growth of nanotechnology has led to a tremendous research and development to exploit their novel properties in various fields including diagnostic imaging. To date, iodine has been clinically used as a radiographic contrast medium. However, raising concern of iodine threats lead to an exploration of new contrast media with lower toxic level. In animal modeling study, gold nanoparticles (GNPs) and iron oxide nanoparticles (IONPs) have been assessed for toxicity properties as compared to conventional iodine. Nanotoxicities were assessed in liver and kidney tissues by hematology and biochemical analyses, ROS and MDA production, histology and ultrastructural evaluation, and followed by apoptosis and DNA damage induction. The hematological and biochemical analyses revealed that most of the parameters were significantly increased in iodine-administered group compared to those in control group and NPs-administered groups (p < 0.05). ROS and MDA production were recorded as significantly reduced in NPs-administered group (p < 0.05). Histological and ultrastructural evaluations showed that there were significant alteration in liver and kidney tissues of iodine-administered rats (p < 0.05) compared to control and NPs groups. Apoptosis was not detected in both NPs-administered groups while it was observed in iodine-administered group. Induction of DNA damage by comet assay was significantly observed in iodine-administered group compared to other groups {p < 0.05). The present study documented that intravenous administration of GNPs and IONPs did not induce appreciable toxicity compared to iodine, hence postulated that GNPs and IONPs could be potentially utilized in radiographic imaging. 2015 Thesis NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/15852/1/TM_MUHAMAD%20IDHAM%20MOHAMED%20HS%2015_5.pdf Mohamed, Muhamad Idham (2015) Toxicity profiling of gold and iron oxide nanoparticles as a radiographic contrast media / Muhamad Idham Mohamed. Masters thesis, Universiti Teknologi MARA.
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
topic	Radiation physics (General)
spellingShingle	Radiation physics (General) Mohamed, Muhamad Idham Toxicity profiling of gold and iron oxide nanoparticles as a radiographic contrast media / Muhamad Idham Mohamed
description	Exponential growth of nanotechnology has led to a tremendous research and development to exploit their novel properties in various fields including diagnostic imaging. To date, iodine has been clinically used as a radiographic contrast medium. However, raising concern of iodine threats lead to an exploration of new contrast media with lower toxic level. In animal modeling study, gold nanoparticles (GNPs) and iron oxide nanoparticles (IONPs) have been assessed for toxicity properties as compared to conventional iodine. Nanotoxicities were assessed in liver and kidney tissues by hematology and biochemical analyses, ROS and MDA production, histology and ultrastructural evaluation, and followed by apoptosis and DNA damage induction. The hematological and biochemical analyses revealed that most of the parameters were significantly increased in iodine-administered group compared to those in control group and NPs-administered groups (p < 0.05). ROS and MDA production were recorded as significantly reduced in NPs-administered group (p < 0.05). Histological and ultrastructural evaluations showed that there were significant alteration in liver and kidney tissues of iodine-administered rats (p < 0.05) compared to control and NPs groups. Apoptosis was not detected in both NPs-administered groups while it was observed in iodine-administered group. Induction of DNA damage by comet assay was significantly observed in iodine-administered group compared to other groups {p < 0.05). The present study documented that intravenous administration of GNPs and IONPs did not induce appreciable toxicity compared to iodine, hence postulated that GNPs and IONPs could be potentially utilized in radiographic imaging.
format	Thesis
author	Mohamed, Muhamad Idham
author_facet	Mohamed, Muhamad Idham
author_sort	Mohamed, Muhamad Idham
title	Toxicity profiling of gold and iron oxide nanoparticles as a radiographic contrast media / Muhamad Idham Mohamed
title_short	Toxicity profiling of gold and iron oxide nanoparticles as a radiographic contrast media / Muhamad Idham Mohamed
title_full	Toxicity profiling of gold and iron oxide nanoparticles as a radiographic contrast media / Muhamad Idham Mohamed
title_fullStr	Toxicity profiling of gold and iron oxide nanoparticles as a radiographic contrast media / Muhamad Idham Mohamed
title_full_unstemmed	Toxicity profiling of gold and iron oxide nanoparticles as a radiographic contrast media / Muhamad Idham Mohamed
title_sort	toxicity profiling of gold and iron oxide nanoparticles as a radiographic contrast media / muhamad idham mohamed
publishDate	2015
url	http://ir.uitm.edu.my/id/eprint/15852/ http://ir.uitm.edu.my/id/eprint/15852/1/TM_MUHAMAD%20IDHAM%20MOHAMED%20HS%2015_5.pdf
first_indexed	2023-09-18T22:54:47Z
last_indexed	2023-09-18T22:54:47Z
_version_	1777417781765996544

Toxicity profiling of gold and iron oxide nanoparticles as a radiographic contrast media / Muhamad Idham Mohamed

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