Phytochemical study and bio activity from the stem bark of Shore a macroptera dyer / Nur Ainaa Atikah Mohd Nazri

Shorea macroptera from family Dipterocarpaceae was studied for its phytochemical and biological activities. Eight compounds have been isolated including two compounds in mixture which consists of nine resveratrol oligomers and an isoferrulic derivative. The compounds were identified as (^-pentacosyl...

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Main Author:	Mohd Nazri, Nur Ainaa Atikah
Format:	Thesis
Language:	English
Published:	2014
Online Access:	http://ir.uitm.edu.my/id/eprint/16397/ http://ir.uitm.edu.my/id/eprint/16397/1/TM_NUR%20AINAA%20ATIKAH%20MOHD%20NAZRI%20AS%2014_5.pdf

id	uitm-16397
recordtype	eprints
spelling	uitm-163972019-02-21T02:00:50Z http://ir.uitm.edu.my/id/eprint/16397/ Phytochemical study and bio activity from the stem bark of Shore a macroptera dyer / Nur Ainaa Atikah Mohd Nazri Mohd Nazri, Nur Ainaa Atikah Shorea macroptera from family Dipterocarpaceae was studied for its phytochemical and biological activities. Eight compounds have been isolated including two compounds in mixture which consists of nine resveratrol oligomers and an isoferrulic derivative. The compounds were identified as (^-pentacosyl 3-(3-hydroxy-4-methoxyphenyl) acrylate, E-viniferin, davidiol A, hemsleyanol D, hopeaphenol A, hopeaphenol, isohopeaphenol, stenophyllol B, gnetol and laevifonol. Gnetol is a monomer resveratrol, £- viniferin and laevifonol are dimer resveratrols, davidiol A and stenophyllol B are trimer resveratrols while hemsleyanol D, hopeaphenol A, hopeaphenol and isohopeaphenol are tetramer resveratrols. Structural elucidation was performed with the aid of spectroscopic methods such as ultraviolet (UV), infrared (IR), mass spectrometry (MS), ID and 2D nuclear magnetic resonance (NMR). Shorea macroptera extract and some of the isolated compounds have been tested for antioxidant, antibacterial and also cytotoxic activities. Shorea macroptera extract showed good antioxidant and antibacterial activities compared to individual isolated compounds, e-viniferin demonstrated marked cytotoxic activity which strongly inhibited HL-60 cell lines but moderately on HeLa cell lines. Davidiol A showed significant cytotoxic activities. It strongly inhibited HL-60 cell lines but moderately inhibited HeLa cell line. Hemsleyanol D moderately inhibited the growth of HeLa cell line. Hopeaphenol displayed significant free radical scavenging activity. Stenophyllol B was found active in free radical scavenging and cytotoxic activities. Stenophyllol B exhibited moderate free radical activity and moderately inhibited HL-60 cell lines and HeLa cell lines. However, laevifonol was inactive towards all three assay tested. 2014 Thesis NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/16397/1/TM_NUR%20AINAA%20ATIKAH%20MOHD%20NAZRI%20AS%2014_5.pdf Mohd Nazri, Nur Ainaa Atikah (2014) Phytochemical study and bio activity from the stem bark of Shore a macroptera dyer / Nur Ainaa Atikah Mohd Nazri. Masters thesis, Universiti Teknologi MARA.
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
description	Shorea macroptera from family Dipterocarpaceae was studied for its phytochemical and biological activities. Eight compounds have been isolated including two compounds in mixture which consists of nine resveratrol oligomers and an isoferrulic derivative. The compounds were identified as (^-pentacosyl 3-(3-hydroxy-4-methoxyphenyl) acrylate, E-viniferin, davidiol A, hemsleyanol D, hopeaphenol A, hopeaphenol, isohopeaphenol, stenophyllol B, gnetol and laevifonol. Gnetol is a monomer resveratrol, £- viniferin and laevifonol are dimer resveratrols, davidiol A and stenophyllol B are trimer resveratrols while hemsleyanol D, hopeaphenol A, hopeaphenol and isohopeaphenol are tetramer resveratrols. Structural elucidation was performed with the aid of spectroscopic methods such as ultraviolet (UV), infrared (IR), mass spectrometry (MS), ID and 2D nuclear magnetic resonance (NMR). Shorea macroptera extract and some of the isolated compounds have been tested for antioxidant, antibacterial and also cytotoxic activities. Shorea macroptera extract showed good antioxidant and antibacterial activities compared to individual isolated compounds, e-viniferin demonstrated marked cytotoxic activity which strongly inhibited HL-60 cell lines but moderately on HeLa cell lines. Davidiol A showed significant cytotoxic activities. It strongly inhibited HL-60 cell lines but moderately inhibited HeLa cell line. Hemsleyanol D moderately inhibited the growth of HeLa cell line. Hopeaphenol displayed significant free radical scavenging activity. Stenophyllol B was found active in free radical scavenging and cytotoxic activities. Stenophyllol B exhibited moderate free radical activity and moderately inhibited HL-60 cell lines and HeLa cell lines. However, laevifonol was inactive towards all three assay tested.
format	Thesis
author	Mohd Nazri, Nur Ainaa Atikah
spellingShingle	Mohd Nazri, Nur Ainaa Atikah Phytochemical study and bio activity from the stem bark of Shore a macroptera dyer / Nur Ainaa Atikah Mohd Nazri
author_facet	Mohd Nazri, Nur Ainaa Atikah
author_sort	Mohd Nazri, Nur Ainaa Atikah
title	Phytochemical study and bio activity from the stem bark of Shore a macroptera dyer / Nur Ainaa Atikah Mohd Nazri
title_short	Phytochemical study and bio activity from the stem bark of Shore a macroptera dyer / Nur Ainaa Atikah Mohd Nazri
title_full	Phytochemical study and bio activity from the stem bark of Shore a macroptera dyer / Nur Ainaa Atikah Mohd Nazri
title_fullStr	Phytochemical study and bio activity from the stem bark of Shore a macroptera dyer / Nur Ainaa Atikah Mohd Nazri
title_full_unstemmed	Phytochemical study and bio activity from the stem bark of Shore a macroptera dyer / Nur Ainaa Atikah Mohd Nazri
title_sort	phytochemical study and bio activity from the stem bark of shore a macroptera dyer / nur ainaa atikah mohd nazri
publishDate	2014
url	http://ir.uitm.edu.my/id/eprint/16397/ http://ir.uitm.edu.my/id/eprint/16397/1/TM_NUR%20AINAA%20ATIKAH%20MOHD%20NAZRI%20AS%2014_5.pdf
first_indexed	2023-09-18T22:55:59Z
last_indexed	2023-09-18T22:55:59Z
_version_	1777417856310312960

Phytochemical study and bio activity from the stem bark of Shore a macroptera dyer / Nur Ainaa Atikah Mohd Nazri

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