Harm reduction in cartilage tissue engineering experimentation: a comparative review between Islamic and conventional ethics / Muhammad Aa’zamuddin Ahmad Radzi … [et al.]

Articular cartilage acts as a load-bearer in human joints. It is prone to injuries or damages by various factors which may lead to irreversible osteoarthritic condition if left untreated. Cartilage Tissue Engineering (TE) is a part of regenerative medicine domains which aims to repair, regenerate an...

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Main Author:	Ahmad Radzi, Muhammad Aa’zamuddin
Format:	Conference or Workshop Item
Language:	English
Published:	2015
Online Access:	http://ir.uitm.edu.my/id/eprint/16630/ http://ir.uitm.edu.my/id/eprint/16630/1/PRO_MUHAMMAD%20AA%27ZAMUDDIN%20AHMAD%20RADZI%20M%2015.pdf

id	uitm-16630
recordtype	eprints
spelling	uitm-166302019-08-14T03:31:27Z http://ir.uitm.edu.my/id/eprint/16630/ Harm reduction in cartilage tissue engineering experimentation: a comparative review between Islamic and conventional ethics / Muhammad Aa’zamuddin Ahmad Radzi … [et al.] Ahmad Radzi, Muhammad Aa’zamuddin Articular cartilage acts as a load-bearer in human joints. It is prone to injuries or damages by various factors which may lead to irreversible osteoarthritic condition if left untreated. Cartilage Tissue Engineering (TE) is a part of regenerative medicine domains which aims to repair, regenerate and restore cartilage biological functions. Despite this great discovery, harm and therapeutic uncertainties spark the ethical concerns surround the technology. This review paper identifies the potential harms in cartilage TE and suggest ways to overcome those issues before the technique can be applied to the patients. The paper presents a discourse from Islamic and conventional ethical viewpoints. The diverse outlooks include their definition of ethics and their sources of references. A thorough examination of the processes in cartilage TE experimentation; serves to give the audience a clear view of the possible or underlying ethical issues, the details of which are explained in this paper. Among the issues to be discussed are; (1) cell harvesting from donor, (2) materials use and safety concerns of implanted constructs, and (3) animal utilization in proof of concept study. Islamic ethics and conventional ethical theories seem to be in agreement on the general principles of harm reduction in cartilage TE. However, there are differences between the approaches of these two ethical systems on issues related to the cartilage TE principles. To be able to harmonise the differing stances between Islamic and conventional bioethics can help bridge those differences within the socio-religious context. Furthermore, it should benefit the Muslim practitioners in terms of the presence of a discourse that could reduce the Islamic religious concerns towards the technique. It is hoped that all the identified socio-religious ethical challenges in cartilage TE can be addressed before it reaches the clinical application. Indeed, this technology can be applied in a minimally invasive manner. 2015 Conference or Workshop Item PeerReviewed text en http://ir.uitm.edu.my/id/eprint/16630/1/PRO_MUHAMMAD%20AA%27ZAMUDDIN%20AHMAD%20RADZI%20M%2015.pdf Ahmad Radzi, Muhammad Aa’zamuddin (2015) Harm reduction in cartilage tissue engineering experimentation: a comparative review between Islamic and conventional ethics / Muhammad Aa’zamuddin Ahmad Radzi … [et al.]. In: 1st International Islamic Heritage Conference (ISHEC) 2015, 11-12 November 2015, Hotel Mahkota, Melaka.
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
description	Articular cartilage acts as a load-bearer in human joints. It is prone to injuries or damages by various factors which may lead to irreversible osteoarthritic condition if left untreated. Cartilage Tissue Engineering (TE) is a part of regenerative medicine domains which aims to repair, regenerate and restore cartilage biological functions. Despite this great discovery, harm and therapeutic uncertainties spark the ethical concerns surround the technology. This review paper identifies the potential harms in cartilage TE and suggest ways to overcome those issues before the technique can be applied to the patients. The paper presents a discourse from Islamic and conventional ethical viewpoints. The diverse outlooks include their definition of ethics and their sources of references. A thorough examination of the processes in cartilage TE experimentation; serves to give the audience a clear view of the possible or underlying ethical issues, the details of which are explained in this paper. Among the issues to be discussed are; (1) cell harvesting from donor, (2) materials use and safety concerns of implanted constructs, and (3) animal utilization in proof of concept study. Islamic ethics and conventional ethical theories seem to be in agreement on the general principles of harm reduction in cartilage TE. However, there are differences between the approaches of these two ethical systems on issues related to the cartilage TE principles. To be able to harmonise the differing stances between Islamic and conventional bioethics can help bridge those differences within the socio-religious context. Furthermore, it should benefit the Muslim practitioners in terms of the presence of a discourse that could reduce the Islamic religious concerns towards the technique. It is hoped that all the identified socio-religious ethical challenges in cartilage TE can be addressed before it reaches the clinical application. Indeed, this technology can be applied in a minimally invasive manner.
format	Conference or Workshop Item
author	Ahmad Radzi, Muhammad Aa’zamuddin
spellingShingle	Ahmad Radzi, Muhammad Aa’zamuddin Harm reduction in cartilage tissue engineering experimentation: a comparative review between Islamic and conventional ethics / Muhammad Aa’zamuddin Ahmad Radzi … [et al.]
author_facet	Ahmad Radzi, Muhammad Aa’zamuddin
author_sort	Ahmad Radzi, Muhammad Aa’zamuddin
title	Harm reduction in cartilage tissue engineering experimentation: a comparative review between Islamic and conventional ethics / Muhammad Aa’zamuddin Ahmad Radzi … [et al.]
title_short	Harm reduction in cartilage tissue engineering experimentation: a comparative review between Islamic and conventional ethics / Muhammad Aa’zamuddin Ahmad Radzi … [et al.]
title_full	Harm reduction in cartilage tissue engineering experimentation: a comparative review between Islamic and conventional ethics / Muhammad Aa’zamuddin Ahmad Radzi … [et al.]
title_fullStr	Harm reduction in cartilage tissue engineering experimentation: a comparative review between Islamic and conventional ethics / Muhammad Aa’zamuddin Ahmad Radzi … [et al.]
title_full_unstemmed	Harm reduction in cartilage tissue engineering experimentation: a comparative review between Islamic and conventional ethics / Muhammad Aa’zamuddin Ahmad Radzi … [et al.]
title_sort	harm reduction in cartilage tissue engineering experimentation: a comparative review between islamic and conventional ethics / muhammad aa’zamuddin ahmad radzi … [et al.]
publishDate	2015
url	http://ir.uitm.edu.my/id/eprint/16630/ http://ir.uitm.edu.my/id/eprint/16630/1/PRO_MUHAMMAD%20AA%27ZAMUDDIN%20AHMAD%20RADZI%20M%2015.pdf
first_indexed	2023-09-18T22:56:30Z
last_indexed	2023-09-18T22:56:30Z
_version_	1777417889164296192

Harm reduction in cartilage tissue engineering experimentation: a comparative review between Islamic and conventional ethics / Muhammad Aa’zamuddin Ahmad Radzi … [et al.]

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