Phytochemical studies and bioactivities of xylopia ferruginea hook. (annonaceae) and shorea maxwelliana king (dipterocarpaceae) / Nik Khairunissa' Nik Abdullah Zawawi

Phytochemical studies and bioactivities of xylopia ferruginea hook. (annonaceae) and shorea maxwelliana king (dipterocarpaceae) / Nik Khairunissa' Nik Abdullah Zawawi

In the present work, phytochemical studies were conducted on two species from different family. The studied plant samples were the stem bark and leaves of Xylopia ferruginea; and the stem bark of Shorea maxwelliana. Phytochemical investigation on the crude alkaloidal extracts of the stem bark and le...

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Main Author: Nik Abdullah Zawawi, Nik Khairunissa
Format: Thesis
Language:English
Published: 2012
Online Access:http://ir.uitm.edu.my/id/eprint/17596/
http://ir.uitm.edu.my/id/eprint/17596/2/TM_NIK%20KHAIRUNISSA%20%27%20ABDULLAH%20ZAWAWI%20AS%2012_5.pdf
id uitm-17596
recordtype eprints
spelling uitm-175962018-11-14T07:51:36Z http://ir.uitm.edu.my/id/eprint/17596/ Phytochemical studies and bioactivities of xylopia ferruginea hook. (annonaceae) and shorea maxwelliana king (dipterocarpaceae) / Nik Khairunissa' Nik Abdullah Zawawi Nik Abdullah Zawawi, Nik Khairunissa In the present work, phytochemical studies were conducted on two species from different family. The studied plant samples were the stem bark and leaves of Xylopia ferruginea; and the stem bark of Shorea maxwelliana. Phytochemical investigation on the crude alkaloidal extracts of the stem bark and leaves of this plant yielded five oxoaporphinoid alkaloids and three flavonols, characterised as O-methylmoschatoline, lysicamine, liriodenine, atherospermidine, oxostephanine, quercetin, kaempferol and afzelin. Phytochemical investigation carried out on the stem bark of Shorea maxwelliana King has yielded five oligostilbenoids identified as a-viniferin, maximol A, vaticanol A, suffruticosol A and vaticanol G. Structure elucidation and characterization of isolated compounds were done based on ID, 2D NMR, IR, UV, MS, optical rotation, melting point and in good agreement with those previously reported for these compounds. In addition, the antibacterial activity of major isolated compounds was tested against seven bacteria. Our findings showed that (9-methylmoschatoline is the most active compound as it inhibited the growth of all tested bacteria and the highestinhibition were shown in S. aureus (20 mm) and S. epidermis (23 mm). Vaticanol G showed moderate and slight activity against S. aureus and E. coli, while maximol A exhibited slight activity against E. coli and P. aeroginosa. Maximol A, suffruticosol A, vaticanol A and vaticanol G possessed active cyctotoxic activity against HL60 cell line with IC₅₀ values range of 10.1 - 220 μM.. Only maximol A was active against A549 and MCF-7 cell lines, with both IC₅₀ value of 220 and 99.2 μM. 2012 Thesis NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/17596/2/TM_NIK%20KHAIRUNISSA%20%27%20ABDULLAH%20ZAWAWI%20AS%2012_5.pdf Nik Abdullah Zawawi, Nik Khairunissa (2012) Phytochemical studies and bioactivities of xylopia ferruginea hook. (annonaceae) and shorea maxwelliana king (dipterocarpaceae) / Nik Khairunissa' Nik Abdullah Zawawi. Masters thesis, Universiti Teknologi MARA.
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institution Universiti Teknologi MARA
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language English
description In the present work, phytochemical studies were conducted on two species from different family. The studied plant samples were the stem bark and leaves of Xylopia ferruginea; and the stem bark of Shorea maxwelliana. Phytochemical investigation on the crude alkaloidal extracts of the stem bark and leaves of this plant yielded five oxoaporphinoid alkaloids and three flavonols, characterised as O-methylmoschatoline, lysicamine, liriodenine, atherospermidine, oxostephanine, quercetin, kaempferol and afzelin. Phytochemical investigation carried out on the stem bark of Shorea maxwelliana King has yielded five oligostilbenoids identified as a-viniferin, maximol A, vaticanol A, suffruticosol A and vaticanol G. Structure elucidation and characterization of isolated compounds were done based on ID, 2D NMR, IR, UV, MS, optical rotation, melting point and in good agreement with those previously reported for these compounds. In addition, the antibacterial activity of major isolated compounds was tested against seven bacteria. Our findings showed that (9-methylmoschatoline is the most active compound as it inhibited the growth of all tested bacteria and the highestinhibition were shown in S. aureus (20 mm) and S. epidermis (23 mm). Vaticanol G showed moderate and slight activity against S. aureus and E. coli, while maximol A exhibited slight activity against E. coli and P. aeroginosa. Maximol A, suffruticosol A, vaticanol A and vaticanol G possessed active cyctotoxic activity against HL60 cell line with IC₅₀ values range of 10.1 - 220 μM.. Only maximol A was active against A549 and MCF-7 cell lines, with both IC₅₀ value of 220 and 99.2 μM.
format Thesis
author Nik Abdullah Zawawi, Nik Khairunissa
spellingShingle Nik Abdullah Zawawi, Nik Khairunissa
Phytochemical studies and bioactivities of xylopia ferruginea hook. (annonaceae) and shorea maxwelliana king (dipterocarpaceae) / Nik Khairunissa' Nik Abdullah Zawawi
author_facet Nik Abdullah Zawawi, Nik Khairunissa
author_sort Nik Abdullah Zawawi, Nik Khairunissa
title Phytochemical studies and bioactivities of xylopia ferruginea hook. (annonaceae) and shorea maxwelliana king (dipterocarpaceae) / Nik Khairunissa' Nik Abdullah Zawawi
title_short Phytochemical studies and bioactivities of xylopia ferruginea hook. (annonaceae) and shorea maxwelliana king (dipterocarpaceae) / Nik Khairunissa' Nik Abdullah Zawawi
title_full Phytochemical studies and bioactivities of xylopia ferruginea hook. (annonaceae) and shorea maxwelliana king (dipterocarpaceae) / Nik Khairunissa' Nik Abdullah Zawawi
title_fullStr Phytochemical studies and bioactivities of xylopia ferruginea hook. (annonaceae) and shorea maxwelliana king (dipterocarpaceae) / Nik Khairunissa' Nik Abdullah Zawawi
title_full_unstemmed Phytochemical studies and bioactivities of xylopia ferruginea hook. (annonaceae) and shorea maxwelliana king (dipterocarpaceae) / Nik Khairunissa' Nik Abdullah Zawawi
title_sort phytochemical studies and bioactivities of xylopia ferruginea hook. (annonaceae) and shorea maxwelliana king (dipterocarpaceae) / nik khairunissa' nik abdullah zawawi
publishDate 2012
url http://ir.uitm.edu.my/id/eprint/17596/
http://ir.uitm.edu.my/id/eprint/17596/2/TM_NIK%20KHAIRUNISSA%20%27%20ABDULLAH%20ZAWAWI%20AS%2012_5.pdf
first_indexed 2023-09-18T22:58:39Z
last_indexed 2023-09-18T22:58:39Z
_version_ 1777418024068841472

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