Effects of pure tocotrienols on the status of endothelial activation, inflammation, oxidative stress and plaque stability in the prevention of early and established experimental atherosclerosis / Nurmazni Zulkafli

Atherosclerosis is one of the leading causes of coronary artery disease (CAD). Studies on the cardioprotective activities of tocotrienols (T3) in the absence of alpha tocopherol (TCP) remain obscure. The aim of this study was to evaluate the effects of pure T3 supplementation on lipid lowering, tiss...

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Main Author:	Zulkafli, Nurmazni
Format:	Thesis
Language:	English
Published:	2016
Online Access:	http://ir.uitm.edu.my/id/eprint/17912/ http://ir.uitm.edu.my/id/eprint/17912/2/TM_NURMAZNI%20ZULKAFLI%20MD%2016_5.pdf

id	uitm-17912
recordtype	eprints
spelling	uitm-179122018-08-15T06:21:50Z http://ir.uitm.edu.my/id/eprint/17912/ Effects of pure tocotrienols on the status of endothelial activation, inflammation, oxidative stress and plaque stability in the prevention of early and established experimental atherosclerosis / Nurmazni Zulkafli Zulkafli, Nurmazni Atherosclerosis is one of the leading causes of coronary artery disease (CAD). Studies on the cardioprotective activities of tocotrienols (T3) in the absence of alpha tocopherol (TCP) remain obscure. The aim of this study was to evaluate the effects of pure T3 supplementation on lipid lowering, tissue endothelial activation and inflammatory biomarkers, and oxidative stress in early and established atherosclerosis rabbit model. Fifteen New Zealand white rabbits were divided into two intervention groups: Al [given 2 months normal diet (ND) and 2 weeks high cholesterol diet (HCD)] and A2 (given 2 months ND and 2 months HCD). Each group was further divided into three groups: T3- 4mg/kg and T3-15mg/kg supplementation groups given pure T3 (delta90%-gammal0%) and placebo. Interventions were given throughout the study. Fasting serum lipids, plasma C-reactive protein and 8-isoprostanes were measured at baseline, 4, 8, 10, 12, 16 weeks… 2016 Thesis NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/17912/2/TM_NURMAZNI%20ZULKAFLI%20MD%2016_5.pdf Zulkafli, Nurmazni (2016) Effects of pure tocotrienols on the status of endothelial activation, inflammation, oxidative stress and plaque stability in the prevention of early and established experimental atherosclerosis / Nurmazni Zulkafli. Masters thesis, Universiti Teknologi MARA.
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
description	Atherosclerosis is one of the leading causes of coronary artery disease (CAD). Studies on the cardioprotective activities of tocotrienols (T3) in the absence of alpha tocopherol (TCP) remain obscure. The aim of this study was to evaluate the effects of pure T3 supplementation on lipid lowering, tissue endothelial activation and inflammatory biomarkers, and oxidative stress in early and established atherosclerosis rabbit model. Fifteen New Zealand white rabbits were divided into two intervention groups: Al [given 2 months normal diet (ND) and 2 weeks high cholesterol diet (HCD)] and A2 (given 2 months ND and 2 months HCD). Each group was further divided into three groups: T3- 4mg/kg and T3-15mg/kg supplementation groups given pure T3 (delta90%-gammal0%) and placebo. Interventions were given throughout the study. Fasting serum lipids, plasma C-reactive protein and 8-isoprostanes were measured at baseline, 4, 8, 10, 12, 16 weeks…
format	Thesis
author	Zulkafli, Nurmazni
spellingShingle	Zulkafli, Nurmazni Effects of pure tocotrienols on the status of endothelial activation, inflammation, oxidative stress and plaque stability in the prevention of early and established experimental atherosclerosis / Nurmazni Zulkafli
author_facet	Zulkafli, Nurmazni
author_sort	Zulkafli, Nurmazni
title	Effects of pure tocotrienols on the status of endothelial activation, inflammation, oxidative stress and plaque stability in the prevention of early and established experimental atherosclerosis / Nurmazni Zulkafli
title_short	Effects of pure tocotrienols on the status of endothelial activation, inflammation, oxidative stress and plaque stability in the prevention of early and established experimental atherosclerosis / Nurmazni Zulkafli
title_full	Effects of pure tocotrienols on the status of endothelial activation, inflammation, oxidative stress and plaque stability in the prevention of early and established experimental atherosclerosis / Nurmazni Zulkafli
title_fullStr	Effects of pure tocotrienols on the status of endothelial activation, inflammation, oxidative stress and plaque stability in the prevention of early and established experimental atherosclerosis / Nurmazni Zulkafli
title_full_unstemmed	Effects of pure tocotrienols on the status of endothelial activation, inflammation, oxidative stress and plaque stability in the prevention of early and established experimental atherosclerosis / Nurmazni Zulkafli
title_sort	effects of pure tocotrienols on the status of endothelial activation, inflammation, oxidative stress and plaque stability in the prevention of early and established experimental atherosclerosis / nurmazni zulkafli
publishDate	2016
url	http://ir.uitm.edu.my/id/eprint/17912/ http://ir.uitm.edu.my/id/eprint/17912/2/TM_NURMAZNI%20ZULKAFLI%20MD%2016_5.pdf
first_indexed	2023-09-18T22:59:20Z
last_indexed	2023-09-18T22:59:20Z
_version_	1777418067052068864

Effects of pure tocotrienols on the status of endothelial activation, inflammation, oxidative stress and plaque stability in the prevention of early and established experimental atherosclerosis / Nurmazni Zulkafli

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