Neuroprotective effect of virgin coconut oil on Lipopolysaccharide-induced cell death in Sk-N-Sh and memory impairment in rat / Nur Syafiqah Rahim
Neuroinflammation has been implicated in the pathogenesis of Alzheimer’s Disease (AD) and often characterized by activation of glial cells and the subsequent upregulation of various cytokines. Neuronal damage would then set in and lead to deterioration of cognitive function. Virgin Coconut Oil (VCO)...
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| Format: | Thesis |
| Language: | English |
| Published: |
2015
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| Online Access: | http://ir.uitm.edu.my/id/eprint/18468/ http://ir.uitm.edu.my/id/eprint/18468/2/TM_NUR%20SYAFIQAH%20RAHIM%20PH%2015_5.pdf |
| Summary: | Neuroinflammation has been implicated in the pathogenesis of Alzheimer’s Disease (AD) and often characterized by activation of glial cells and the subsequent upregulation of various cytokines. Neuronal damage would then set in and lead to deterioration of cognitive function. Virgin Coconut Oil (VCO) has been reported to possess anti-bacterial, anti-viral, anti-oxidants and anti-inflammatory properties. Capitalizing on these therapeutic effects, the present study investigated for the first time the potential neuroprotective effect of VCO in vitro and in vivo. For this purpose, neuroprotection by VCO against amyloid-β-(A(3) and Lipopolysaccharide(LPS)- induced cell death and Reactive Oxygen Species (ROS) production of SK-N-SH (neuroblastoma cells) was assessed. The in vitro findings were validated using normal and LPS-induced memory impaired animal models in vivo. A total of 36 male Wistar rats (7-8 weeks) were randomly assigned to 6 groups (n=6 /group). The treatment groups were administered with 1, 5 and 10mL/kg of VCO for 31 days by oral gavages… |
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