Neuroprotective effect of virgin coconut oil on Lipopolysaccharide-induced cell death in Sk-N-Sh and memory impairment in rat / Nur Syafiqah Rahim

Neuroinflammation has been implicated in the pathogenesis of Alzheimer’s Disease (AD) and often characterized by activation of glial cells and the subsequent upregulation of various cytokines. Neuronal damage would then set in and lead to deterioration of cognitive function. Virgin Coconut Oil (VCO)...

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Main Author:	Rahim, Nur Syafiqah
Format:	Thesis
Language:	English
Published:	2015
Online Access:	http://ir.uitm.edu.my/id/eprint/18468/ http://ir.uitm.edu.my/id/eprint/18468/2/TM_NUR%20SYAFIQAH%20RAHIM%20PH%2015_5.pdf

id	uitm-18468
recordtype	eprints
spelling	uitm-184682019-02-20T03:26:50Z http://ir.uitm.edu.my/id/eprint/18468/ Neuroprotective effect of virgin coconut oil on Lipopolysaccharide-induced cell death in Sk-N-Sh and memory impairment in rat / Nur Syafiqah Rahim Rahim, Nur Syafiqah Neuroinflammation has been implicated in the pathogenesis of Alzheimer’s Disease (AD) and often characterized by activation of glial cells and the subsequent upregulation of various cytokines. Neuronal damage would then set in and lead to deterioration of cognitive function. Virgin Coconut Oil (VCO) has been reported to possess anti-bacterial, anti-viral, anti-oxidants and anti-inflammatory properties. Capitalizing on these therapeutic effects, the present study investigated for the first time the potential neuroprotective effect of VCO in vitro and in vivo. For this purpose, neuroprotection by VCO against amyloid-β-(A(3) and Lipopolysaccharide(LPS)- induced cell death and Reactive Oxygen Species (ROS) production of SK-N-SH (neuroblastoma cells) was assessed. The in vitro findings were validated using normal and LPS-induced memory impaired animal models in vivo. A total of 36 male Wistar rats (7-8 weeks) were randomly assigned to 6 groups (n=6 /group). The treatment groups were administered with 1, 5 and 10mL/kg of VCO for 31 days by oral gavages… 2015 Thesis NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/18468/2/TM_NUR%20SYAFIQAH%20RAHIM%20PH%2015_5.pdf Rahim, Nur Syafiqah (2015) Neuroprotective effect of virgin coconut oil on Lipopolysaccharide-induced cell death in Sk-N-Sh and memory impairment in rat / Nur Syafiqah Rahim. Masters thesis, Universiti Teknologi MARA.
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
description	Neuroinflammation has been implicated in the pathogenesis of Alzheimer’s Disease (AD) and often characterized by activation of glial cells and the subsequent upregulation of various cytokines. Neuronal damage would then set in and lead to deterioration of cognitive function. Virgin Coconut Oil (VCO) has been reported to possess anti-bacterial, anti-viral, anti-oxidants and anti-inflammatory properties. Capitalizing on these therapeutic effects, the present study investigated for the first time the potential neuroprotective effect of VCO in vitro and in vivo. For this purpose, neuroprotection by VCO against amyloid-β-(A(3) and Lipopolysaccharide(LPS)- induced cell death and Reactive Oxygen Species (ROS) production of SK-N-SH (neuroblastoma cells) was assessed. The in vitro findings were validated using normal and LPS-induced memory impaired animal models in vivo. A total of 36 male Wistar rats (7-8 weeks) were randomly assigned to 6 groups (n=6 /group). The treatment groups were administered with 1, 5 and 10mL/kg of VCO for 31 days by oral gavages…
format	Thesis
author	Rahim, Nur Syafiqah
spellingShingle	Rahim, Nur Syafiqah Neuroprotective effect of virgin coconut oil on Lipopolysaccharide-induced cell death in Sk-N-Sh and memory impairment in rat / Nur Syafiqah Rahim
author_facet	Rahim, Nur Syafiqah
author_sort	Rahim, Nur Syafiqah
title	Neuroprotective effect of virgin coconut oil on Lipopolysaccharide-induced cell death in Sk-N-Sh and memory impairment in rat / Nur Syafiqah Rahim
title_short	Neuroprotective effect of virgin coconut oil on Lipopolysaccharide-induced cell death in Sk-N-Sh and memory impairment in rat / Nur Syafiqah Rahim
title_full	Neuroprotective effect of virgin coconut oil on Lipopolysaccharide-induced cell death in Sk-N-Sh and memory impairment in rat / Nur Syafiqah Rahim
title_fullStr	Neuroprotective effect of virgin coconut oil on Lipopolysaccharide-induced cell death in Sk-N-Sh and memory impairment in rat / Nur Syafiqah Rahim
title_full_unstemmed	Neuroprotective effect of virgin coconut oil on Lipopolysaccharide-induced cell death in Sk-N-Sh and memory impairment in rat / Nur Syafiqah Rahim
title_sort	neuroprotective effect of virgin coconut oil on lipopolysaccharide-induced cell death in sk-n-sh and memory impairment in rat / nur syafiqah rahim
publishDate	2015
url	http://ir.uitm.edu.my/id/eprint/18468/ http://ir.uitm.edu.my/id/eprint/18468/2/TM_NUR%20SYAFIQAH%20RAHIM%20PH%2015_5.pdf
first_indexed	2023-09-18T23:00:36Z
last_indexed	2023-09-18T23:00:36Z
_version_	1777418146896936960

Neuroprotective effect of virgin coconut oil on Lipopolysaccharide-induced cell death in Sk-N-Sh and memory impairment in rat / Nur Syafiqah Rahim

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